Objective To identify factors for blood disqualification,so as to take appropriate measures to prevent or reduce the blood disqualification.Methods According to the Operation Standards of Blood Station[No.448(2000)]published by the Ministry of Public Health,blood qualification and disqualification was judged.The blood samples were divided into three groups:group 1 collected from the mode of planning donation without reward;group 2 from the mode of voluntary blood donation without reward;and group 3 from the combination of the above.Results Totally 63 408 u were collected during the four years,of which 2 418 were disqualified and the disqualification rate was 3.81%.The disqualification rate of group 3(4.75%)was the highest,followed by that of group 2 (4.24%)and group 1(1.82%).There was significant difference among the samples collected from different months.And the descending order of blood type of disqualified blood was as follows:type O,A, B, and AB.The existence of anti-TP antibody and ALT elevation were the two main factors for blood disqualification,which disqualification rate was 1.73% and 0.93% respectively.Conclusion It suggests that propaganda of blood donation knowledge,selection of blood donors,ID and finger print identification for them,quality control of the blood station should be enhanced so as to prevent or reduce the blood disqualification.

To compare herbalogy literature through the ages, ancient prescription literature, modern national pharmacopoeia and modern Chinese materia medica, we can confirm that the core of the traditional functions about atractylodes macrocephala have been recorded in modern national pharmacopoeia and Chinese materia medica. But atractylodes macrocephala's effects in treating anemofrigid-damp arthralgia, vomit, abdominal crymodynia, hypochondnrium or abdominal mass, chills and fever, all anemo-illness, dead muscle, gastric heat, spasm, jaundice, violent pathogenic wind, headache, five kinds of strain and seven impairments, therm-disease, epidemic pathogenic factors from mountains, knob and boss, agerasia and so on, were not included nowadays. By analysing the syndrome of the compatibility in ancient prescriptions including atractylodes macrocephala, some functions can be extracted, such as eliminating fever, calming down wind and stopping spasm, stopping cough, stopping wheez, calming the nerves, stopping bleeding, alleviating pain, promoting the production of body fluid. Whether atractylodes macrocephala has those functions need to be confirmed through empirical study and clinical research.

Objective:To study potential function of relieving-pain,calming and stopping bleeding function of astragali.Methods:To observe the effect of the water decoction of high,middle and low doses astragali on physical pain(hot plate method) and chemical-induced pain(writhing method)in mice reaction;the effect on the sleep durance of mouse which was applied under valve dosage of sodium pentobarbital and impact of blood coagulation in rats.It was compared with the blank control group,as well as the positive control group.Results:Astragali decoction can increase the pain threshold in mice,reduce the number of writhing in mice,enhance the volume of the role of sleep in mice on the threshold of sodium pentobarbital hypnosis,and extend the role of sodium pentobarbital hypnosis time.At the same time can shorten the prothrombin time and partial thromboplastin time,and increase fibrinogen.Conclusion:Astragali had definite relieving-pain,calming and stopping bleeding function.This result was consistent with the analysis conclusions through ancient prescriptions database with astragali.

Objective To study the toxicity of herbicide,butachlor,to myocardium of Bufo bufo gargarizans. Methods One hundred and sixty Bufo bufo gargarizans were randomly divided into control group,paddy goup,5 times paddy group,10 times paddy group,forty in each group and the exposure was conducted in the experimental containers at the concentrations of 1,5,10 times of the application dosages( 5,10,30 ml/L) ,1/2 of the body of Bufo bufo gargarizans was immersed in the sulotion. After 3,6,9 days of exposure,electrocardiogram was recorded using calculator living creature signal analysis system and the structures of atrium muscle and ventricles muscle were observed with HE stain. Results The structure of myocardial cells of Bufo bufo gargarizans was damaged by butachlor with different levels. Pathological examination showed that the myocardial cells appeared necrosis in different degrees with the increasing doses of butachlor. Butachlor could affact the eletrocardiogram of Bufo bufo gargarizans with obvious dose-time-dependent manner,time-dependent manner was even dominant. Abnormal electrocardiogram was seen,P-R and Q-T changed. Conclusion Butachlor exposure can damage the structure and eletrocardiogram of myocardial cell in Bufo bufo gargarizans.

Objective To apply the feedback closed-loop management systemin the telephone follow-up service for discharged patients to increase patient satisfaction and improve the quality of nursing. Methods From January 2015,telephone return visit to discharged patients were analyzed, a summary of dissatisfaction events, analyze the causes every month. Then,the improvement measures for nursing quality were put forward and the effects were evaluated to form a closed-loop management system. Results After the application of feedback closed-loop management system,there was a significant difference in patients' satisfaction with nursing service between the first half (with the incidence of 91.77%,3657/3985) and the second half (with the incidence of 95.76%,3610/3770) of 2015 (χ2=52.22, P < 0.01). Of the 9 items of dissatisfaction recorded in the questionnaire, significant difference was observed in 8 items, as service attitude, hospitalizing education, personal care, question answering, nurse's operation, health education, respect, clean environment and the discharge instructions. The incidence of each item was 2.11%(84/3985), 0.23%(9/3985), 0.35%(14/3985), 0.33%(13/3985), 0.30%(12/3985), 2.99%(119/3985), 0.33%(13/3985), 0.58%(23/3985), 2.58%(103/3985) in the first half of 2015 respectively, compared to 1.09%(41/3770), 0.05%(2/3770), 0.05%(2/3770), 0.08%(3/3770), 0.21%(8/3770), 0.64%(24/3770), 0.85%(32/3770), 0.21%(8/3770), 1.25%(47/3770) in the second half of 2015 respectively (χ2=4.084-59.088,P<0.01 or 0.05). However, no significant difference was observed in the nurse operational between the first half (0.30%) and the second half (0.21%) in 2015 (χ2=0.596, P>0.05). Conclusions Feedback closed-loop management systemic a scientific management theory. It can increase patient satisfaction with nursing service,improve the quality of nursing,and make quality management more scientific and effective .

Through the investigation on functions of E.rutaecarpain ancient herbal literatures,ancient prescriptions and the Chinese Pharmacopoeia(2010 edition),it showed that the basic function of E.rutaecarpa recorded in herbal literatures through dynasties was similar to that of the Chinese Pharmacopoeia.However,the disappearance of Euodia rutaecarpa's functions in the Chinese Pharmacopoeia were dampness-eliminating,blood-activating,spleen-invigorating,phlegm-eliminating,wind-dispelling,and guiding fire to its source,which had been recorded in ancient herb literatures.ThePu-Ji-Fang database management system contained prescriptions with Euodia rutaecarpa in the treatment of asthenia,Bi syndrome,stroke,scabies,edema,phlegm,leukorrhagia,epigastric pain,menoxenia,lochiostasis,fractures,sore,aphtha,and etc,which were absent from the Chinese Pharmacopoeia.In conclusion,we preliminarily confirmed that Euodia rutaecarpahad potential functions in activating blood to resolve stasis,dispelling wind and eliminating dampness,nourishing deficiency and invigorating the spleen,resolving toxins,relieving cough and eliminating phlegm,soothing liver to stop wind,as well as stopping bleeding.

Objective To analyse of 150 cases of type A aortic dissection anatomic parameter and the relationship between anatomic parameter and clinic date and prognosis.Methods We identified 150 cases of type A aortic dissection who were diagnosed clearly.All patients were divided into groups by gender and surgical approaches.General clinic data and radiological data were recorded.Survival rate was evaluated by follow up 3 months after surgery.Results The aortic root diameter of group aortic root replacement was(53.25±13.17)mm,group aortic root sparing was (49.08±6.94)mm,there was significant difference between the two group(P<0.05);survival rate was 86.84% and 79.79%,respectively.There was no relevance between diameter of aortic arch and branch with the aortic arch surgery way.The starting diameter of two group were (54.47±9.69)mm and(54.48±8.30)mm,the diameter of aortic arch were (31.39±7.14)mm and(32.73±6.59)mm,respectively.The anonymous artery diameter were (14.65±3.00)mm and(14.28±2.99)mm,respectively.The left common carotid artery diameter were(9.81±2.33)mm and(9.56±2.10)mm,respectively.The start diameter of the left subclavian artery were(11.15±2.84)mm and(11.13±2.56)mm(all P>0.05).There were gender differences between type A dissection parameters of descending aorta,the start diameter of male and female's descending aorta were (41.09±8.86)mm and(37.44±5.60)mm,respectively.The descending aorta in parallel to the pulmonary artery diameter were(34.31±0.59)mm and(31.11±0.88)mm,respectively.Descending aorta diameter of the diaphragm were(31.45±6.50)mm and(28.46±5.20)mm,respectively(all P>0.05).Conclusion In patients who suffer from type A aortic dissection,Parameter of aortic root is one of factors which determine surgical approach to aortic root.When treating descending aorta,surgeon should consider the influence of gender.Our study provided data references for selection and design of endovascular stent-graft.

OBJECTIVE To observe the effect of the quickread bioindicator. METHODS According to the GB15981-1995 The Measures and the Standards of the Assessment of Disinfection and Sterilization,to control conventionally the(7 high-pressure) steam sterilization cabinets by the quickread-bioindicators. RESULTS Using the effective control method shortened the waiting time by 45 hours,and in-time provided the qualified disinfected supply. CONCLUSIONS The effect of using the quickread-bioindicator resolves the problem of delay of the control result.This is an ideal,scientific,and practical method for effective control of the high pressure steam sterilization.

Tumor is a complex systemic disease, involving abnormalities at multiple levels, such as DNA, RNA, protein and metabolite. According to the central rule, the derived omics methods are genomics, transcriptomics, proteomics and metabonomics. In the past few decades, there have been remarkable achievements in the single omics study of tumor, but the exact mechanism of tumor development is still unclear. In order to reveal the process of tumorigenesis and development in a more systematic way, the research of multiomics came into being, which promoted the transformation of tumor research paradigm from single parameter model to multi parameter system model. The integration of multi-omics methods is expected to clarify the mechanism of tumor occurrence and development, find biomarkers with diagnostic, prognostic and predictive performance, explore new treatment targets, and finally achieve predictive, preventive, and personalized medicine (PPPM). This paper reviews the research methods and progress of different omics techniques in tumor research, especially emphasizes the importance and scientific value of the integration of multiple omics techniques in tumor research and clinical related results.

Objective To evaluate the efficacy and safety of itraconazole injection in treatmeat of invasive fungal infections.Methods The clinical trial was conducted in 16 patients(17 times)with invasive fungal infection from August 2003 to August 2005,including 1 case confirmed,11 cases(12 times)suspected and 4 cases for empiric treatment.They were treated with iv itraconazole injection in a dose of 200 mg twice daily in the first and the second day,from the third day to 14th day they were given iv itraconazole injection in a dose of 200 mg once daily,and then treated with capsule in a dose of 200 mg twice daily for another 28 days.Two cases were treated with iv itraconazole injection in a dose of 200 mg twice daily for 9 days and 14 days;1 case in a dose of 200 mg once daily for 21 days.Results 62 strains were isolated from 16 patients with invasive fungal infection,including 40 strains in urine cultivate,and 21 strains of tropic candida were primacy.In confirmed and suspected patients,the cure rate was 6/13,the effective rate was 11/13 and the eradication rate was 6/13.The incidence of adverse reaction was 3/24.Conclusion Itraconazole injection is effective and safe in treatment of severe invasive fungal infections,especially in severe ill,old patients for long time use.