1.Information Therapy Research Review
Journal of Medical Informatics 2017;38(2):48-51,68
The paper introduces the origin and definition of information therapy,analyzes the study object of information therapy including information prescription,users,healthcare opportunity and so on,describes the efficacy and function in healthcare of information therapy on relationship establishment,cost effect,patient education,patient safety,health realization,etc.,points out the future development direction of information therapy.
2.Forensic practice in sudden infant death syndrome
Chinese Journal of Forensic Medicine 1987;0(03):-
Sudden infant death syndrome(SIDS) has become a highlighted topic in forensic medicine and pediatrics since it was firstly defined in 1969.As some great improvements were preceded in many aspects,people know more about its features,summarization,classification and related genes.There are many reports from developed areas such as North America,Europe,Australia,Japan etc.,but few from China.This review introduces SIDS's development history,new scientific findings and discusses the feasibility of further SIDS studies and the key points in forensic practice under the influence of San Diego definition of SIDS.
3.Exploration on improving the teaching quality of oncological probation
Chinese Journal of Medical Education Research 2003;0(03):-
This article analyses the characteristics and current situation in oncology teaching,and studies the goals,task and methods on oncological probation.
5.Intervention of Ginkgo biloba extract on renal hemodynamics and its clinical protective mechanism
Hongfeng HUANG ; Qian LIANG ; Lan LAN ; Jianyong WU ; Jianghua CHEN
Chinese Journal of Organ Transplantation 2015;36(11):652-656
Objective To observe the effect and safety of Ginkgo biloba extract (EGb) in patients with chronic allograft nephropathy (CAN),and to study the clinical protective mechanism of EGb.Method A prospective,non-randomized,controlled study was conducted on 103 cases of CAN from March 2013 to March 2015.All patients were divided into experimental group (group A,53 cases) and control group (group B,50 cases).The group A was treated with EGb.Patients were followed up for at least 6 months.Before and after treatment,the changes in renal hemodynamic parameters were observed.The biochemical parameters were also observed,including 24-h urinary protein,urinary albumin,serum creatinine (Scr),triglyceride (TG),total cholesterol (TC),estimated glomerular filtration rate (eGFR),platelet count (PLT),fibrinogen (FIB),D-dimer (DD),activated partial thromboplastin time (APTT).The clinical efficacy and safety were analyzed.Result (1) Therewere no significant differences in clinical and biochemical parameters between the two groups before treatment (P>0.05).(2) After treatment,the systolic peak flow velocity (Vmax) of segmental artery and arcuate artery in the experimental group was significantly higher than in the control group,and the resistance index (RI) in the experimental group was significantly lower than that in the control group,P<0.05.(3) In both two groups,the 24-h urinary protein,urinaryalbumin,TG,TC and Scr were decreased after treatment (P<0.05),and eGFR was elevated (P<0.05).Moreover,the changes in 24-h urinary protein and urinary albumin in the experimental group were more significant than the control group after treatment (P<0.05).(3) PLT,FIB and DD in experimental group were significantly decreased after treatment,and APTT was increased significantly (P<0.05).PLT,FIB,DD and APTT had significant change after treatment in the experimental group as compared with control group.(4) There were no significant differences in adverse reactions between two groups (x2 =0.047,P =0.828).Conclusion The therapy of EGb in patients with CAN could reduce urinary protein and improve hypercoagulable state,and had few adverse reaction with good security.
8.Autophagy pathways and key drug targets in Parkinson's disease.
Liang OUYANG ; Lan ZHANG ; Bo LIU
Acta Pharmaceutica Sinica 2016;51(1):9-17
Parkinson's disease (PD) is a common neurodegenerative disorder associated with aging. Great progresses have been made toward understanding the pathogenesis over the past decades. It seems that both genetic factors and environmental factors contribute to PD, while the precise pathogenesis still remains unknown. Recently, increasing evidence has suggested that autophagy dysregulation is closely related to PD. Dysregulation of the autophagic pathways has been observed in the brains of PD patients or in animal models of PD, and a number of PD-associated proteins, such as a-synuclein, Parkin and PINK1, were found to involve in autophagy, suggesting a link between autophagy and pathogenesis of PD. In this review, we summarized the role of PD-associated proteins in autophagy pathways. In addition, we described the efficacy of autophagy-modulating compounds in PD models and discussed promising strategies for PD therapy.
Animals
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Autophagy
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Humans
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Parkinson Disease
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physiopathology
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Protein Kinases
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metabolism
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Ubiquitin-Protein Ligases
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metabolism
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alpha-Synuclein
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metabolism
10.Application of mivacurium in moden non-convulsively electuoconvulsive therapy
Yingping LAN ; Tianbei LIANG ; Yiwei WANG
The Journal of Clinical Anesthesiology 2014;(6):584-585
Objective To observe the effect of mivacurium,succinylcholine and atracurium in modified electric convulsive therapy (MECT).Methods Sixty ASA Ⅰ or Ⅱ patients with schizo-phrenia aged from 18 to 60 years old were randomly divided into 3 groups :mivacurium group (group A,n=20),succinylcholine group (group B,n=20),atracurium group (group C,n=20).The on-set time of muscle relaxation,the recovery time of spontaneous breathing after MECT,the awake time,as well as the changes of 5 min MAP,HR and SpO2 before and after MECT were observed re-spectively.Results The onset time of muscle relaxation and the recovery time of spontaneous breath-ing in group B were shorter than those in groups A and C (P <0.05).The onset time of muscle re-laxation and the recovery time of spontaneous breathing in group A were shorter than those in group C (P <0.05).Conclusion Mivacurium is a better alternative medicine in MECT in the situation of no succinylcholine or succnylcholine contraindication.