Jinagsu Province is one of the provinces with high incidence of poliomyelitis historically. Eradication of poliomyelitis in the province had experienced five stages as follows: (1) Stage before administration of oral polio vaccines (OPV) (1956～1960); (2) Beginning of OPV administration (1961～1969); (3) Extensive administration of OPV (1970～1978); (4) Implementation of expanded program on immunization (EPI) (1979～1989) and (5)Eradication of poliomyelitis (1990～1999). While reviewing the adopted strategies in the process of polio eradication, two points should be emphasized: (1) To raise the OPV immunization coverage rate unceasingly. After carrying out in Jiangsu Province the EPI, we have taken steps to strengthen the construction of cold chain and to standardize the vaccination in clinics, thus to ensure the vaccination quatity. Based on routine polio vaccination, still we carried out supplementary vaccination to establish an effective immune barrier among the population; (2) To strengthen the AFP surveillance. The AFP surveillance system had been established in 1991 in Jiangsu Province, the various surveillance indexes now has reached every requirements for proving no polio virus exists. In the course of surveillance, we pursued a case-reporting encouragement system and an active AFP searching at regular intervals to strengthen AFP case reporting and surveillance. Since 1993, there was no wild-type polio virus found. To summarize and evaluate the strategies for poliomyelitis eradication not only can consolidate the achievements of the work but also can provide reference in controlling other viral diseases.