1.Preparation of V(E) acetate-loaded amphiphilic block copolymer nano-dispersions.
Jun LI ; Liandong DENG ; Chunmei YAO ; Yang ZHANG ; Anjie DONG
Journal of Biomedical Engineering 2009;26(1):101-104
V(E) acetate-loaded methoxy poly(ethylene glycol)-b-poly(lactic acid) amphiphilic diblock copolymer nano-dispersion (PMV) was prepared by self-emulsification/solvent evaporation method. The drug-loaded amount, size distribution of PMV nanoparticles, and entrapment efficiency of V(E) acetate (V(E)A) were determined by UV and laser particle analyzer. Drug release in vitro was primarily investigated by UV. The results indicate that the size of PMV nanoparticles is less than 300 nm and PMV is largely influenced by preparation methods, property of solvents, V(E)A-fed amount, and the concentration of dispersion. The initial burst release is not observed and the accumulated release is more than 79% after 14 h. This study develops a new formulation for V(E)A and provides an experimental basis for the novel drug delivery systems of V(E)A.
Delayed-Action Preparations
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chemical synthesis
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Drug Carriers
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administration & dosage
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chemistry
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Hydrophobic and Hydrophilic Interactions
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Nanoparticles
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Polyesters
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administration & dosage
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Polyethylene Glycols
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administration & dosage
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Vitamin E
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administration & dosage
2.Studies on paclitaxel-loaded methoxy poly (ethylene glycol)/poly (L-lactic acid) diblock copolymer nanoparticles.
Liandong DENG ; Duoxian SUN ; Yueting ZHANG ; Jianzhong HUO ; Yingjin YUAN ; Anjie DONG
Journal of Biomedical Engineering 2005;22(4):715-718
Paclitaxel-loaded methoxy poly (ethylene glycol )-b-poly (L-lactic acid) diblock copolymer nanoparticles (PMT) were prepared by a self-emulsification/solvent evaporation method. The PMT morphology, size and its distribution, and drug release in vitro were investigated by DLS, UV, TEM and HPLC. The results indicate that PMT show a spherical morphology with inner core and outer shell. The diameter (nm) of PMT increases with the increase of the drug-loaded amount. The initial burst release is not observed, the drug releasing rate in vitro is lower, and the accumulated release increases with the increase of replacement amout of the pH7. 4 medium. This study develops a new formulation for paclitaxel and provides an experimental basis for the intravenous administration of paclitaxel.
Antineoplastic Agents, Phytogenic
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administration & dosage
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Delayed-Action Preparations
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Drug Carriers
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administration & dosage
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chemistry
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Humans
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Injections, Intravenous
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Nanoparticles
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Paclitaxel
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administration & dosage
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Polyesters
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administration & dosage
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chemistry
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Polyethylene Glycols
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administration & dosage
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chemistry
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Polymers
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administration & dosage
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chemistry