OBJECTIVEIn order to study on effects of soy extract on energy metabolims in ovariectomized rats.

METHOD90 Wistar rats were randomly divided into 9 groups: control group, sham group, model group, estrogen group, soy isoflavone group of high dose, soy isoflavone of low dose, soy extract of high dose, soy extract of low dose, 10 rats each group. Beside of control and sham groups, the rest rats were ovariectomized. One week after operation, the rats were treatmented with different drugs, measument of body weigh and feed weigh each week. Six week after operation, the rats were killed, serum were taken, abdomen lipid were removed and weight.

RESULTThe ovariectomized rats took more food and got weight gain significantly; Body mess index(BMI), Abdomen lipid weigh and food transform rate in Model group increased significantly than control and sham groups. Administration of estrogen or soy extract or soy isoflavone could block these changes in ovariectomized rats, but soy polysaccharides did not have the effects.

CONCLUSIONOvariectomized rats have imbalance of energy metabolism, weigh gain and accumulation of abdomen lipid; administration of estrogen, soy extracts or soy isoflavone could attenuate these changes induced by ovariectomizing.

Animals ; Body Mass Index ; Energy Metabolism ; drug effects ; Estrogens ; pharmacology ; Female ; Isoflavones ; isolation & purification ; pharmacology ; Ovariectomy ; Plant Extracts ; isolation & purification ; pharmacology ; Polysaccharides ; isolation & purification ; pharmacology ; Rats ; Rats, Wistar ; Soybeans ; chemistry ; Weight Gain ; drug effects