ObjectiveTo observe the effect of the computer operation training on patients with cervical spinal cord injury. Methods16 patients with cervical spinal cord injury were trained to learn Word software operation and typing skill. Modules of Employability Skill (MES) was adopted in the training and the results were measured according to each module and cell. ResultsThe operation Word software and typing speed significantly improved compared with those pre-training (P<0.01 respectively). ConclusionPatients with cervical spinal cord injury can use computers skillfully after good occupational training.

Objective To investigate the chronic angio-complications of diabetes mellitus(DM)and impared glucosetolerance(IGT)patients were diagnosticated newly.Methods 46 patients with diabetes mellitus and 97 pa- tients of impared glucosetolerance were chosen in the study,and 35 patients were chosen as normal glucose tlerance group.Some biochemical criterion,carotid artery intima-media thickness and plaque condition were measure.Results The group of IGT contract coronary heart disease is 62.9 %,cetebrovascular disease is 20.6%,carotid artery atheromatosis is 50.5 %,the group of DM contract coronary heart disease is 65.2%,cerbrovascular disease is 26,1%,carotid artery atheromatosis is 69.6%,it have statistics significance compared with control group(P

This study was based on live yeast cell derivative (LYCD), which was produced by live yeast cell stressed with high temperature and H 2O 2. The results showed that pretreating of low dose(37℃and 0.2mmol/L H 2O 2) could increase the content of GSH and the activity of SOD and CAT. These pretreatment could induce the resistance to lethal concentration of H 2O 2. LYCD was produced by yeast treated with 37℃ and 0.2mmol/L H 2O 2. And it was found that the survival of yeast treated with lethal concentration of H 2O 2 obviously increased, while LYCD was added in yeast culture. It indicated that LYCD could have resistance to oxidative condition.

Abortion, Missed ; chemically induced ; Adult ; Carbon Disulfide ; adverse effects ; Female ; Humans ; Occupational Exposure ; adverse effects ; Pregnancy ; Retrospective Studies ; Risk Factors ; Time Factors

96%).There are 14 nucleotide mutations between yak and cattle and 3 of that were predicted to alter the protein sequence,both of which occurred in the domain III.Construction of molecular phylogenetic tree shows:The cluster results coincided with the traditional taxonomy.

Objective To investigate the mastery degree of GCP (Good Clinical Practice) in Guang’anmen Hospital of China Academy of Chinese Medical Sciences (hereinafter referred to as“Guang’anmen Hospital”). Methods Totally 338 clinical researchers, covering 18 clinical professional sections and medical clinical trial institutions, in Guang’anmen Hospital with both qualification of clinical trials and GCP certificate were investigated in 23th-27th June 2014. The investigation was in the written answer sheet form, including four noun explanations and 36 multiple choice questions, which were related to GCP. Results 338 researchers could accurately explain the concepts of 4 nouns, and 57 (16.86%) researchers could do all multiple choice questions correctly. 141 (41.72%) researchers chose 1 wrong answer and 89 (26.33%) researchers chose 2 wrong answers. 39 (11.54%) researchers failed to answer 3-4 questions. Only 12 (3.55%) researchers failed to answer 5 or more questions. Conclusion The mastery degree of clinical researchers with qualification of clinical trials and GCP certificate in Guang’anmen Hospital is satisfied. In the future, pertinence and diverse training should be strengthened, in order to improve the overall level of the mastery degree of GCP.

Objective To explore the relationship between operation scores and the expression of caveolin-1 ( Cav-1 ) protein in the cortex of mice.Methods Male Kunming mice were used and divided into two groups (excellent group and bad group) according to the training scores after 4 days' Y-maze learning training.The expression of cav-1 protein in cortex and hippocampus of the mice with different scores were measured through Western blot technology.Results Cav-1 protein expression of excellent group( Cav-1/β-actin was 5.71 + 1.11 ) in the cortex was significantly higher than that of the bad group ( Cav-1/β-actin was 1.69 + 0.20) (P ＜ 0.01 ).While there was no significant difference in the two groups in the expression of Cav-1 protein in hippocampus(P ＞ 0.05 ).Conclusion The operation scores have distinct correlation with the expression of Cav-1 protein in the cortex of mice.

Objective: To investigate the mortality and life lost among patients with severe mental illness (SMI) that were registered in Ningbo City from 2016 to 2020, so as to provide the evidence for formulating the SMI control strategy. Methods: All data pertaining to dead SMI patients registered in Ningbo City from 2016 to 2020 were extracted from Ningbo Municipal Mental Health Information Management System. The demographic characteristics and causes of death were analyzed among dead SMI patients, and the life lost was analyzed among dead SMI patients using years of potential life lost (YPLL), years of potential life lost rate (YPLLR) and average years of life lost (AYLL). Results: A total of 3 350 deaths occurred among SMI patients registered in Ningbo City from 2016 to 2020, with mortality of 1 962/105, including 2 490 patients with schizophrenia (74.33%), 1 640 men (48.96%), 1 877 farmers (56.03%), and 2 622 patients with an educational level of primary school and below (78.27%). The dead SMI patients had a median age of 66.8 (interquartile range, 20.1) years at death, and median disease course of 25.8 (interquartile range, 26.7) years. The median age at death was 63.7 (interquartile range, 18.5) years among men, which was significantly lower than that (median, 70.0 years; interquartile range, 19.6 years) among women (χ2=132.633, P<0.001). The patients with mental retardation complicated by mental disorders had the longest disease course (median, 40.3 years; interquartile range, 34.1 years) and the lowest age at death (median, 61.4 years; interquartile range, 21.9 years). Physical disease was identified as the predominant cause of death (2 754 cases, 82.21%), and the YPLL, AYLL and YPLLR due to all causes of death were 44 417.32 person-years, 15.61 years and 6.21‰. The AYLL was significantly greater among men than among women (17.33 vs. 13.75 years; χ2=68.254, P<0.001). The YPLL was 30 156.80 person-years among patients with schizophrenia, and the AYLL was 20.87 years among patients with mental retardation complicated by mental disorders. Conclusions Physical disease was the main cause of death among SMI patients registered in Ningbo City from 2016 to 2020, which posed a great effect on the lifespan among men and patients with schizophrenia and mental retardation complicated by mental disorders.

Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Breast ; pathology ; Breast Neoplasms ; drug therapy ; pathology ; Cyclophosphamide ; therapeutic use ; Diagnosis, Differential ; Doxorubicin ; therapeutic use ; Female ; Follow-Up Studies ; Humans ; Lymphoma, B-Cell ; drug therapy ; pathology ; Lymphoma, Large B-Cell, Diffuse ; drug therapy ; pathology ; Male ; Middle Aged ; Prednisone ; therapeutic use ; Sarcoma ; pathology ; Spleen ; pathology ; Splenic Neoplasms ; drug therapy ; pathology ; Vincristine ; therapeutic use

Objective To analyze the clinical outcomes of patients treated with in vitro fertilization and embryo transfer (IVF-ET) and influence factors of pregnancy rate. Methods We retrospectively analyzed the clinical data of 12 491 cycles, including 6832 fresh IVF/intracytoplast single sperm injection (ICSI) cycles and 5659 frozen embryo transfer (FET) cycles from 2005 to 2007. Results The clinical pregnancy rate per cycle was 32. 99% (2254/6832)in fresh embryo transfer program, and the live birth rate was 25.75% (1394/5413); the early pregnant loss rate was 9. 36% (211/2254), and the prenatal defect rate was 1.45% (25/1722). Through analysis of these patients' basic data, we found that the patients' age, causes for infertility, egg retrieval and cycle number affected the pregnancy rate. Using logistic regression method, we found that patients′ age was the most important factor affecting pregnancy outcome. In FET cycles, the clinical pregnancy rate was 38.08% (2155/5659), significantly higher than fresh embryo transfer cycles. Conclusions IVF-ET treatment is a safe and effective method for infertility couples. However, the female age and poor ovarian response are the main factors affecting pregnancy rate. Thawed embryo transfer can increase the accumulated pregnancy rate effectively.