1.A comparative study of clinical effects of 2-micron laser vaporization resection of prostate versus transurethral resection of prostate for treatment of benign prostatic hyperplasia
Chao ZUO ; Xiaoyi ZHANG ; Chuanhai LIU ; Bo SUN ; Lian ZOU
Clinical Medicine of China 2013;29(9):981-983
Objective To investigate and compare the clinical effects of 2-micron laser vaporization resection of prostate (2-micron laser) and versus transurethral resection of prostate (TURP) for treatment of benign prostatic hyperplasia(BPH) in this prospective random control study.Methods Sixty patients of BPH were randomly divided into two groups including the 2-micron laser group (n =30) and the TURP group (n =30).The perioperative markers and therapeutic results including duration of surgery,blood lose during surgery,improvement of symptoms after treatment,postoperative bladder washing time,the mean bladder irrigating time,hospital stay time,and recent complications were recorded and analyzed.Results The international prostate symptom score((6.6 ± 1.8) vs.(33.2 ±2.2),(5.7 ± 1.3) vs.(33.4 ±2.3) respectively),maximal urinary flow((20.6 ± 1.5) ml/s vs.(7.8 ± 4.3) m/s,(19.5 ± 1.7) ml/s vs.(8.3 ± 4.5) ml/s respectively),residual urine volume((22.3 ±4.7) ml vs.(57.2 ± 10.5) ml,(26.3 ±7.2) ml vs.(60.2 ± 14.5) ml respectively) were significantly improved in both groups after operation (P =0.005,0.008,0.036,0.001,0.005,0.013 respectively),but the differences between these two groups were not significant (P =0.16,0.49,0.97 respectively).The volume of hemorrhage ((20.9 ± 12.1) ml vs.(55.3 ± 27.8) ml),the mean bladder irrigating time ((1.0 ±0.5) d vs.(3.5 ±0.7) d),cathererization time ((3.2 ± 1.3) d vs.(6.0 ± 1.5) d),hospital stay time ((6.8 ±0.7) d vs.(10.6 ±0.6) d) were significantly less or shorter in the 2-micron laser group than in the TURP group (P =0.009,0.005,0.035,0.03 respectively).There was no significant difference in rates of complications between the two groups (P > 0.05).Conclusion The therapy of 2-micron laser is safer and more efficacious than TURP for BPH patients,with advantages of short surgery duration,little blood loss,and quick recovery.
2.Analysis of postoperative complications after ventriculo-peritoneal shunt in children
lian-ping, SUN ; hui-ming, JIN ; bo, YANG
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(03):-
Objective To analyze the curative effects and complications of ventriculo-peritoneal shunt in treating hydrocephalus caused by different diseases in children. Methods The data of 289 children with hydrocephalus who were performed ventriculo-peritoneal shunt were examined and the incidence rate of complications was analyzed. Results Thirty-seven incidences of complications occurred in 24 patients with the total incidence rate of 12.46%.There was obstruction of proximate tube in five cases,distal end in two cases,with the obstruction rate of 2.42%.Postoperative infection happened in nine cases(3.11%).Bacterial culture was positive in three cases,two of which were Staphylococcus epidermidis and Bacillus coli in the other one.Negative results were found in six patients for the bacterial culture.Subdural hematoma occured in one case,and tube break after injury in two cases.Slit ventricle syndrome broke out seven times in three cases,leakage of cerebrospinal fluid in two,exposure of pumps in three,and subcutaneous hydrops in two.Four cases(1.38%)were dead from infection. Conclusion Ventriculo-peritoneal shunt is preferred for hydrocephalus in children if the complications are well prevented and controlled.
3.Research progress of the attentional set-shifting task in rodents
Lanwei HOU ; Hongwei SUN ; Gang WANG ; Bo LIAN ; Nengzhi JIANG ; Lin SUN
Acta Laboratorium Animalis Scientia Sinica 2017;25(3):340-344
Attentional set-shifting tasks are used as a measure of human fronto-executive function.the cognitive processes involved in forming an attentional set,maintaining an attentional set and shifting an attentional set are vulnerable to dysfunction arising from a number of human neurological disorders (such as attentional deficit/hyperactivity disorder,depression,schizophrenia) and neurodegenerative diseases (such as Parkinson's,Huntington's,Alzheimer's diseases).Recently,researches on rodents mainly continue to illustrate normal rats which are caused by different operating different performance in the attentional set-shifting tasks.And also there are few studies committed to observe the adaptability of the rats in attentional set-shifting tasks as well as different performance between species of rodents in attentional set shifting tasks.In addition,these results have elucidated the roles of multiple neurotransmitters in the manifestation of cognitive processes.This review focuses on the methodology of the attentional set-shifting tasks and the role of the neurotransmitter in cognitive processes.
4.Gastric carcinoid tumor with micro-mucinous adenocarcinoma: report of a case.
Hua YANG ; Li-Bo SUN ; Ying WANG ; Lian-You WANG ; Ya-Nan CUI
Chinese Journal of Pathology 2010;39(12):848-849
Adenocarcinoma, Mucinous
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metabolism
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pathology
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surgery
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Carcinoid Tumor
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metabolism
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pathology
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surgery
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Chromogranin A
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metabolism
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Diagnosis, Differential
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Gastrectomy
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methods
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Gastrointestinal Stromal Tumors
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pathology
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Humans
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Male
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Middle Aged
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Neoplasms, Multiple Primary
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metabolism
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pathology
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surgery
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Stomach Neoplasms
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metabolism
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pathology
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surgery
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Synaptophysin
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metabolism
5.Chronic intervillositis of placenta: report of a case.
Yang-mei SHEN ; Yu-ping XIE ; Lian XU ; Bo SONG ; Wei-gang SUN
Chinese Journal of Pathology 2008;37(4):282-283
Adult
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Chronic Disease
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Female
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Humans
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Placenta
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pathology
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Placenta Diseases
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diagnosis
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pathology
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Pregnancy
6.Virtual screening and activity study of antiviral compounds targeting inosine 5′-monophosphate dehydrogenase
Shi-bo KOU ; Rong-mei GAO ; Hong YI ; Lian-qi SUN ; Yu-huan LI ; Zhuo-rong LI
Acta Pharmaceutica Sinica 2022;57(10):3011-3018
Inosine 5′-monophosphate dehydrogenase (IMPDH) is a key enzyme catalyzing the rate-limiting step of
7.Redox factor-1 may mediate the repair of multiple organ injuries after liver transplantation
Zhi-Peng SUN ; Yu-Bing ZHU ; Aminbuhe ; Ke GONG ; Bin ZHU ; Qing FAN ; Dong-Bo LIAN
Chinese Medical Journal 2013;126(13):2504-2509
Background Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) is an important enzyme in the repair of reactive oxygen species-induced DNA damage,and its expression/activation can be induced by reactive oxygen species.The aim of this research was to investigate the relationship between multiple-organ injuries and expression of Ref-1 in the early period after liver transplantation.Methods One hundred and fifty adult male Wistar rats were divided randomly into three groups:liver transplantation,sham surgery,and untreated control.After liver transplantation,animals were sacrificed at different time points.Hepatic and renal functions were analyzed by serology.Histology,apoptotic levels,and Ref-1 expression were examined by immunohistochemistry in the liver,kidneys,intestines,and lungs.Results Serum levels of alanine aminotransferase and aspartate aminotransferase peaked 6 hours after liver transplantation and decreased appreciably after 12 hours in the transplantation group,suggesting that the degree of liver injury in the early period after transplantation peaked at 6 hours and then decreased.Pathological analyses showed that hepatic tissues were more severely injured in the transplantation group than in the sham and untreated groups.A considerable number of infiltrating inflammatory cells was observed around the portal vein in the transplantation group.Injuries to the kidneys,intestines,and lungs were milder after liver transplantation.Apoptotic levels increased after liver transplantation in all four organs examined.Ref-1 expression was higher in the transplantation group in the early period after liver transplantation than in the sham surgery and untreated control groups.Conclusion Ref-1 expression induced by ischemia-reperfusion injury may have a critical role in repairing multiple-organ injuries after liver transplantation.
8.Diagnosis of thyroid nodules with ultrasound-guided fine needle aspiration: comparison of solid lesion and complex lesion
Wen-bo LI ; Qing-li ZHU ; Yu-xin NG JIA ; Bo ZHANG ; Qing DAI ; Pin GAO ; Di YANG ; Jian SUN ; Xiao-ping XING ; Xiao-lan LIAN
Chinese Journal of Ultrasonography 2011;20(8):680-683
Objective To compare the efficacy of ultrasound-guided fine-needle aspiration(US-FNA)biopsy in diagnosing solid and complex thyroid nodules with different size. Methods One hundred and seventy-five thyroid FNA biopsies were prospectively performed on 168 patients ranging from 4 to 75 years of age. Sixty-three nodules were surgically excised and the others were clinically followed-up. The cytology diagnoses were categorized into four groups: benign, malignant, suspicious and unsatisfactory. Results There was no significant complication in the all 115 solid and 60 complex thyroid lesions and there were 36and 3 malignant nodules respectively in solid and complex thyroid nodules. The nondiagnostic rates of solid and complex nodules were 7% and 8%. The accuracy of US-FNA in diagnosing complex thyroid nodules was comparatively equal to that of in solid thyroid nodules. In solid thyroid nodules, the sensitivity and accuracy in ≤1 cm group were similar to that of in >1 cm group. Conclusions US-FNA was an accurate and reliable method to diagnose thyroid solid and complex lesions.
9.Clinical Study on Treatment of Infantile Rotaviral
Lian-Bo WEI ; Zhi-Jun LI ; Bao-Tian CHEN ; Sheng-Yun SUN ; Tu LUAN ; Yun-Fei GAO ; Ji-Lai LI
Chinese journal of integrative medicine 2001;7(2):86-89
Objective: To observe the clinical effect of guava leaf (GL) in treating infantile rotaviral enteritis.Methods: Sixty-two patients of rotaviral enteritis were randomly divided into the treated group treated with GL and the control group treated with Gegen Qinlian Decoction. The time for ceasing diarrhea, content of Na+ in blood, content of Na+ and glucose in stool, and the rate of negative conversion of human rotavirus antigen (HRVA) were observed.Results: The 3-day recovery rate in the treated group (87.1%) was significantly higher than that in the control group (58.1%, P<0.05). The time of ceasing diarrhea in the treated group (25.1±9.5 hrs) was significantly shorter than that in the control group (38.7±15.2 hrs, P<0.01). Moreover, content of Na+ and glucose in stool were reduced obviously in the treated group but not in the control group; and negative conversion rate of HRVA in the former group also got better than that in the latter group (87.1% vs 58.1%, P<0.05). Consequently, the effect of GL was superior to that of the control significantly.Conclusion: GL has good curative effect on infantile rotaviral enteritis.
10.Research progress on the mechanism of rapid antidepressant action of hydronorketamine
Xianqiang ZHANG ; Bo LIAN ; Changjiang LI ; Guohua LU ; Hongwei SUN ; Lin SUN
Chinese Journal of Behavioral Medicine and Brain Science 2020;29(2):183-188
Major depressive disorder is a mental illness characterized by depressed mood, lack of engagement in pleasurable activities, anhedonia, and cognitive-behavioral disorders. Currently, traditional pharmacological treatments for depression have a delayed therapeutic onset and low treatment effectiveness. (2R, 6R)-HNK, as a key metabolite of ketamine, can not only exert rapid and lasting antidepressant effects but also has no side effects such as hallucination and addiction caused by ketamine, which has potential clinical application values. Studies have found that the antidepressant effect of (2R, 6R)-HNK is closely related to the regulation mechanism of glutamate receptor and synaptic plasticity. Besides, the changes of downstream signaling pathways include the upregulation of brain-derived neurotrophic factor (BDNF) expression, dephosphorylation of eukaryotic elongation factor 2 (eEF2), and activation of the mammalian target of rapamycin (mTOR) play a key role in the antidepressant process of the drug. Understanding the molecular mechanisms underpinning (2R, 6R)-HNK's antidepressant effects will be invaluable for the identification of targets, which will drive the development of novel, effective, next-generation pharmacotherapies for the treatment of depression.