Child ; Humans ; Male ; Thyroiditis, Suppurative ; pathology

Activin is a growth factor belong to the transforming growth factor-? superfamily.Recently,experimental studies have shown that activin and activin A expressed higher in various brain injury models and activin have beneficial roles to neuronal protection.The high correlation of activin and activin A with clinical and biochemical signs of brain injury lead us to suggest that activin and activin A are new possible indicators to predict and treat brain injury.

BACKGROUND:Pediatric knee dysfunction is a congenital malformation. Fusion and fixation can effectively eliminate pain, but no joint has active function. Total knee arthroplasty is a safe and effective method to relieve pain and to rebuild its function. With the continuous development of total knee arthroplasty, the type of knee prostheses is more. OBJECTIVE: To study the efficacy of different reconstruction methods for children with stunted knee arthroplasty. METHODS:120 knee stunted children were equaly divided into treatment group and control group depended on the reconstruction, and then al children were given the artificial knee replacement surgery and were completed by the same group of physicians. In the control group, stable fixed platform prosthesis was selected. In the treatment group, the non-limiting prosthetic-posterior cruciate ligament resection of low contact pressure rotating platform prosthesis was given. Operative time, blood loss, postoperative hospital stay, and complications were observed in both groups. Al patients were folowed up for 3 months. Knee function was assessed by Hospital for Special Surgery and American knee society knee score. Multivariate regression analysis was used to analyze the possible factors affecting Hospital for Special Surgery score during folow up. RESULTS AND CONCLUSION: No significant difference in operative time, blood loss and postoperative hospital stay was compared in both groups (P> 0.05). The postoperative overal incidences of inflammatory response, wound healing, periprosthetic infection, and joint stiff were significantly lower in the treatment group than in the control group (P < 0.05). At 3-month folowed-up, Hospital for Special Surgery and American knee society knee score clinical score and functional score were significantly higher in the treatment group than in the control group (P < 0.05). Hospital for Special Surgery score > 80 served as a standard. Multivariate regression analysis results showed that age, type of prosthesis, and varus deformity were the major independent risk factors for affecting joint replacement (P< 0.05). Results indicate that knee arthroplasty for knee dysfunction obtained good prognostic effect. Simultaneously, the non-limiting application of prosthetic reconstruction can effectively reduce postoperative complications and improve knee function.

Objective To study the effect of evidence-based nursing combined with KAP model on health education to the parturients from suburbs.Methods According to problems in 200 pregnant women from suburban areas, health education was performed to them using evidence-based nursing and KAP model. The rate of access to knowledge, confidence about laboring, spontaneous participation in action to promote delivery, natural birth rate, episiotomy rate, breastfeeding rate and rate for satisfaction with midwives were compared between pre-and post-health education.Results After intervention, their access to knowledge, confidence about laboring, spontaneous participation in action to promote delivery were obviously improved than those before intervention(P<0.05). The rate of natural birth, cesarean delivery, forceps delivery and satisfaction with midwives were 66.0 %, 30.0 %, 1.0% and 94.4 %, respectively.Conclusion Evidence-based nursing and KAP model is effective in the health education to pregnant women from suburbs.

Lifestyle intervention is basic and background treatment for people with type 2 diabetes.Effective lifestyle intervention contributes to better glucose control and delay of diabetic complications.Dietary and exercise interventions as well as lifestyle advice are major components of lifestyle intervention.Dietary intervention focuses on restriction of total caloric intake and balanced nutritional composition,while exercise intervention focuses on exercise mode,frequency,intensity,timing,and duration.This review introduced several lifestyle intervention measures including exercise and dietary interventions as well as lifestyle advice,and discussed their effects on glucose control in people with type 2 diabetes.

Objective:To investigate the effect of lactic acid bacteria on P38 signaling in immune response to dust time in mite-sensitized mice.Methods:40 C57BL/6 mice in Group M,P and C,except for N(saline control),were sensitized and challenged with mite extract.Mice in C and P were simultaneously fed to Lactococcus lactis and Lactobacillus respectively.Total cell count and classification in BALF were done and IL-4 level detected by ELISA.Western blot were performed for detection of P38 signaling from mice's spleen cells stimulated with mite extract.Results:IL-4 level,total cell count and the percentage of eosinophils in BALF were significantly lower in Group C(P

Objective: To compare the immunomodulatory capability to allergic asthma between orally taken Lactococcus lactis and Lactobacillus Lactobacillus plantarum in dust mite-sensitized mice. Methods: C57BL/6 mice were divided into four groups;Group N,M,L and P.Mice in M,Land P groups were sensitized with 2 % mite extract on day 0,7and 14 and challenged with 4% mite extract on day 21,22,23 and 24.Meanwhile we fed Lactococcus lactis and Lactobacillus plantarum to mice in L and P group respectively from each day of sensitization on as well as from the first day of challenge on,continuing for five days.Mice in N and M group were treated with saline as control.Histopathologic examination in the lung tissues of the mice was performed at day 3 after the last challenge.Cell count and classification,and Th1/Th2 cytokine levels in BALF were measured simultaneously.Isolated splenocytes from the mice were subjected to the detection of cell proliferation by BrdU incorporation in response to the mite extract.Using ELISA,the levels of Th1/Th2 cytokines in the supernatant of mite-stimulated splenocytes were measured. Results: Pulmonary allergic inflammation with eosinophilic infiltration as well as increased levels of IL-4 and IL-5 in BALF were observed in mice sensitized/challenged with mite extract(Group M).Pulmonary inflammation was decreased significantly in group L concomitant with down regulated levels of IL-4 and IL-5,total cell count and the percentage of eosinophils in BALF(P

Objective To describe the clinical characteristics,outcome and prognostic factors of primary intraspinal tumor treated with postoperative radiotherapy.Methods Thirty-three patients diagnosed as suffering from intraspinal tumor treated with postoperative radiotherapy were analyzed.There were eighteen male and fifteen female,with a median age of 37 years(range 7-64 years).Two patients were treated with grossly total resection,25 subtotal resection,2 biopsy only.These patients were treated either with(~(60)Co)(n =18,before 1998) or 6?MV-X ray(n =15,after 1998) to the total dose of 45-68?Gy.The overall response and survival rates were calculated by Kaplan-Meier method and the difference between groups was tested by the log-rank method.The prognostic factors related to the characteristics of patient,tumor,and treatment were determined.Results The overall response,five-year and disease-free survival rate was 81.3%,59.4% and 56.3%,respectively.By multivariate analysis,the histological type(P= 0.039) and gender(P= 0.049) had independent impact on the 5-year survival rate.Ependymoma had a better prognosis compared to other histological subsets and female gained more survival advantage over male.There was no close relationship between survival and other factors,such as age,extent of surgery,initial site,irradiation dose,or the interval between surgery and radiotherapy.Conclusions Postoperative radiotherapy is safe and effective for primary intraspinal tumor.The histological type and gender are important prognostic factors of survival in primary intraspinal tumors.

OBJECTIVE: To compare the effects of bupivacaine, lidocaine and saline injections in alleviating post tonsillectomy pain. METHOD: We recruited 60 patients into the study. All subjects were randomly allocated into 3 groups. Group 1 received 0.9% sodium chloride (saline group), group 2 received 0.25% bupivacaine (bupivacaine group) and group 3 received 2% lidocaine (lidocaine group), infiltrated around each tonsil. Pain was evaluated with McGrath's face scale. RESULT: The postoperative pain scores at 2 and 6 hours were similar among the groups (P>0.05). The pain scores in the bupivacaine group were lower than those in the saline group at 12 h (P<0.05). The pain scores in the bupivacaine and lidocaine groups were significantly lower than those in the saline group from 18 to 24 hours until day 7 (P<0.05). There was no difference between the bupivacaine and lidocaine groups (P> 0.05). CONCLUSION Local infiltration of bupivacaine is a relatively and safe effective method and is equivalent to use of lidocaine for post tonsillectomy pain.
Analgesia ; methods ; Bupivacaine ; Child ; Child, Preschool ; Female ; Humans ; Lidocaine ; Male ; Pain Measurement ; Pain, Postoperative ; prevention & control ; Snoring ; surgery ; Tonsillectomy

Neovascular glaucoma ( NVG ) is a series of blinding and intractable eye diseases, which caused by various intraocular or extraocular diseases. The iris and angle neovascularization and vascular membrane fiber contraction may eventually lead to progressive elevation of intraocular pressure and angle closure. Because of complex etiology, the treatment of NVG is intractable and inefficient. Based on the articles published in recent years, we reviewed the progressions of the relevant cytokines and animal models.