Child ; Humans ; Male ; Thyroiditis, Suppurative ; pathology

BACKGROUND:Pediatric knee dysfunction is a congenital malformation. Fusion and fixation can effectively eliminate pain, but no joint has active function. Total knee arthroplasty is a safe and effective method to relieve pain and to rebuild its function. With the continuous development of total knee arthroplasty, the type of knee prostheses is more. OBJECTIVE: To study the efficacy of different reconstruction methods for children with stunted knee arthroplasty. METHODS:120 knee stunted children were equaly divided into treatment group and control group depended on the reconstruction, and then al children were given the artificial knee replacement surgery and were completed by the same group of physicians. In the control group, stable fixed platform prosthesis was selected. In the treatment group, the non-limiting prosthetic-posterior cruciate ligament resection of low contact pressure rotating platform prosthesis was given. Operative time, blood loss, postoperative hospital stay, and complications were observed in both groups. Al patients were folowed up for 3 months. Knee function was assessed by Hospital for Special Surgery and American knee society knee score. Multivariate regression analysis was used to analyze the possible factors affecting Hospital for Special Surgery score during folow up. RESULTS AND CONCLUSION: No significant difference in operative time, blood loss and postoperative hospital stay was compared in both groups (P> 0.05). The postoperative overal incidences of inflammatory response, wound healing, periprosthetic infection, and joint stiff were significantly lower in the treatment group than in the control group (P < 0.05). At 3-month folowed-up, Hospital for Special Surgery and American knee society knee score clinical score and functional score were significantly higher in the treatment group than in the control group (P < 0.05). Hospital for Special Surgery score > 80 served as a standard. Multivariate regression analysis results showed that age, type of prosthesis, and varus deformity were the major independent risk factors for affecting joint replacement (P< 0.05). Results indicate that knee arthroplasty for knee dysfunction obtained good prognostic effect. Simultaneously, the non-limiting application of prosthetic reconstruction can effectively reduce postoperative complications and improve knee function.

Lifestyle intervention is basic and background treatment for people with type 2 diabetes.Effective lifestyle intervention contributes to better glucose control and delay of diabetic complications.Dietary and exercise interventions as well as lifestyle advice are major components of lifestyle intervention.Dietary intervention focuses on restriction of total caloric intake and balanced nutritional composition,while exercise intervention focuses on exercise mode,frequency,intensity,timing,and duration.This review introduced several lifestyle intervention measures including exercise and dietary interventions as well as lifestyle advice,and discussed their effects on glucose control in people with type 2 diabetes.

Objective To study the effect of evidence-based nursing combined with KAP model on health education to the parturients from suburbs.Methods According to problems in 200 pregnant women from suburban areas, health education was performed to them using evidence-based nursing and KAP model. The rate of access to knowledge, confidence about laboring, spontaneous participation in action to promote delivery, natural birth rate, episiotomy rate, breastfeeding rate and rate for satisfaction with midwives were compared between pre-and post-health education.Results After intervention, their access to knowledge, confidence about laboring, spontaneous participation in action to promote delivery were obviously improved than those before intervention(P<0.05). The rate of natural birth, cesarean delivery, forceps delivery and satisfaction with midwives were 66.0 %, 30.0 %, 1.0% and 94.4 %, respectively.Conclusion Evidence-based nursing and KAP model is effective in the health education to pregnant women from suburbs.

Activin is a growth factor belong to the transforming growth factor-? superfamily.Recently,experimental studies have shown that activin and activin A expressed higher in various brain injury models and activin have beneficial roles to neuronal protection.The high correlation of activin and activin A with clinical and biochemical signs of brain injury lead us to suggest that activin and activin A are new possible indicators to predict and treat brain injury.

Objective:To investigate the effect of lactic acid bacteria on P38 signaling in immune response to dust time in mite-sensitized mice.Methods:40 C57BL/6 mice in Group M,P and C,except for N(saline control),were sensitized and challenged with mite extract.Mice in C and P were simultaneously fed to Lactococcus lactis and Lactobacillus respectively.Total cell count and classification in BALF were done and IL-4 level detected by ELISA.Western blot were performed for detection of P38 signaling from mice's spleen cells stimulated with mite extract.Results:IL-4 level,total cell count and the percentage of eosinophils in BALF were significantly lower in Group C(P

Objective: To compare the immunomodulatory capability to allergic asthma between orally taken Lactococcus lactis and Lactobacillus Lactobacillus plantarum in dust mite-sensitized mice. Methods: C57BL/6 mice were divided into four groups;Group N,M,L and P.Mice in M,Land P groups were sensitized with 2 % mite extract on day 0,7and 14 and challenged with 4% mite extract on day 21,22,23 and 24.Meanwhile we fed Lactococcus lactis and Lactobacillus plantarum to mice in L and P group respectively from each day of sensitization on as well as from the first day of challenge on,continuing for five days.Mice in N and M group were treated with saline as control.Histopathologic examination in the lung tissues of the mice was performed at day 3 after the last challenge.Cell count and classification,and Th1/Th2 cytokine levels in BALF were measured simultaneously.Isolated splenocytes from the mice were subjected to the detection of cell proliferation by BrdU incorporation in response to the mite extract.Using ELISA,the levels of Th1/Th2 cytokines in the supernatant of mite-stimulated splenocytes were measured. Results: Pulmonary allergic inflammation with eosinophilic infiltration as well as increased levels of IL-4 and IL-5 in BALF were observed in mice sensitized/challenged with mite extract(Group M).Pulmonary inflammation was decreased significantly in group L concomitant with down regulated levels of IL-4 and IL-5,total cell count and the percentage of eosinophils in BALF(P

Objective To describe the clinical characteristics,outcome and prognostic factors of primary intraspinal tumor treated with postoperative radiotherapy.Methods Thirty-three patients diagnosed as suffering from intraspinal tumor treated with postoperative radiotherapy were analyzed.There were eighteen male and fifteen female,with a median age of 37 years(range 7-64 years).Two patients were treated with grossly total resection,25 subtotal resection,2 biopsy only.These patients were treated either with(~(60)Co)(n =18,before 1998) or 6?MV-X ray(n =15,after 1998) to the total dose of 45-68?Gy.The overall response and survival rates were calculated by Kaplan-Meier method and the difference between groups was tested by the log-rank method.The prognostic factors related to the characteristics of patient,tumor,and treatment were determined.Results The overall response,five-year and disease-free survival rate was 81.3%,59.4% and 56.3%,respectively.By multivariate analysis,the histological type(P= 0.039) and gender(P= 0.049) had independent impact on the 5-year survival rate.Ependymoma had a better prognosis compared to other histological subsets and female gained more survival advantage over male.There was no close relationship between survival and other factors,such as age,extent of surgery,initial site,irradiation dose,or the interval between surgery and radiotherapy.Conclusions Postoperative radiotherapy is safe and effective for primary intraspinal tumor.The histological type and gender are important prognostic factors of survival in primary intraspinal tumors.

Objective To analyze the relationship between serum intermedin ( IMD ) , CystatinC ( CysC ) and fibro-blast growth factor23(FGF23) with hypertensive left ventricular hypertrophy (HLVH). Methods Serum IMD,Cy-sC and FGF23 levels of 30 patients with essential hypertension(EH group),30 hypertensions with LVH(HLVH group)and 30 healthy subjects(control group)were detected by enzyme-linked immunosorbent assay(ELISA). All the subjects did UCG for LVMI. Results LVMI and serum IMD,CysC,FGF23 levels were significantly higher in EH group than in control(P<0. 05),higher in HLVH group than in EH and control groups(P<0. 05). In the pa-tients with hypertension LVMI and serum IMD,CysC,FGF23 levels were increasing with increased blood pressure levels. LVMI level was positively correlated with serum IMD,CysC and FGF23 levels(r=0. 769,0. 517,0. 700;P<0. 01). Line to LVMI level as the dependent variable,multiple stepwise regression analysis showed that:systolic blood pressure( SBP) ,IMD,CysC,homocysteine( Hcy) ,FGF23 entered regression equation. They were independent risk factors for LVMI. Conclusion Serum IMD, CysC and FGF23 levels are closely associated with EH and HLVH. They may participate in the development of EH and affect the process of HLVH. Combined-detection of ser-um IMD,CysC and FGF23 can be used as a reference index for the condition and prognosis of HLVH.

Objective To observe the real-time efficacy of balance acupuncture in treating primary hypertension. Method Totally 160 patients with primary hypertension were randomized into a treatment group and a control group, 80 in each group. The treatment group was intervened by balance acupuncture, while the control group was by oral administration of Captopril. The blood pressure and symptom score were observed before and after intervention. Result There were no significant differences in comparing the total effective rate at different time points between the two groups (P>0.05). There was a significant difference in comparing the headache score in male patients at 30 min after treatment between the two groups (P<0.05). Conclusion Balance acupuncture is an effective method in treating primary hypertension, and can release headache of the patients.