[Objective] To understand Chinese scholars in different periods on the different understanding of tongue, for further development of research and provide a theoretical basis. [Method] Access to a large number of ancient books and literature, selection and tongue of related articles, extract and summa-rize the main points. [Result] The ancient understanding of TCM tongue is very knowledgeable, and by the subjective leading generation, does not have the scientific rigour;modern research of Chinese medicine tongue is mainly from the tongue and tongue color, tongue shape and other aspects, the objec-tive diagnosis and analysis system, the research methods of modern TCM tongue with scientific rigor modern Chinese Medicine; from the point of view, different degrees of col aterals and the width of the color purple tongue, sublingual y reflect the progress of the blood stasis degree and disease conditions, different diseases have different characteristics of the tongue. [Conclusion] Research on the development of modern tongue made certain contribution to TCM development.

Juvenile retinoschisis (RS or XLRS,MIM#312700)is a rare X-linked inherited disorder,mainly affects bilateral retina,and is characterized by cartwheel-like changes of the macular region of the retina and schisis or splitting within the inner retinal layers,leading to visual deterioration.The electroretinogram is beneficial in the diagnosis of juvenile retinoschisis.The a-wave can be of normal or nearly normal amplitude in this disorder,whereas the amplitude of the b-wave is appreciably reduced,giving a decrease in the proportion of b/a.The responsible gene,XLRSl,maps to Xp22 and was identified by positional cloning.This paper makes a brief review about the latest XLRS research of pathogenesis,animal experiments,clinical therapy,and 25 references are cited.

AIM:To investigate the role of SDF-1? in migrating of bone marrow stromal cells to the injured areas. METHODS:Ischemic brain lesion model was created in rats by permanent middle cerebral artery occlusion (MCAO). 48 SD rats were divided randomly into 2 groups. Group 1:phosphate buffered saline (PBS 1 mL) for control (n=25); Group 2:BMSCs (2?106) were injected intravenously at 24 h after MCAO (n=24). After propagated in BMSCs,Ad5/F35 GFP (green fluorescent protein) was infected to BMSCs. The expression of SDF-1? (stromal cell-derived factor-1?) mRNA in the penrumbral tissue was assayed by real-time quantitative PCR. The expression of CXCR4 on MSCs was detected by flow cytometry. Confocal microscopy was used to detect the GFP-labeled MSCs migration. RESULTS:Ad5/F35 GFP signals was observed in almost infected BMSCs. The expressions of SDF-1? mRNA in the thalamus and hippocampus of the ischemic brains were peaked at 3rd day after stroke,followed by a decrease at 14th day post-ischemia. The expression of SDF-1? mRNA in the cortex of the ischemic brains was peaked at 7th day post-ischemia,still at high level at 14th day post-ischemia. The median percentage of surface CXCR4 expression in BMSCs was 14%. GFP labeled BMSCs were detected in the origination of the middle cerebral artery (olfactory area) at 6 h,after 3 days in the prenumbra tissue such as thalamus,and in the cortex more labeled cells were found after 14 d post-ischemia.CONCLUSION:BMSCs can pass through the blood brain barrier of ischemic rats. Its mechanism might be associated with the expression of SDF-1? in the ischemic brain.

Objective To investigate the effect of Xuefuzhuyu pill on blood glucose,sex hormone,insulin levels and HOMA-IR index in patients with polycystic ovary syndrome and infertility.Methods 59 patients with polycystic ovary syndrome and infertility from January 2014 to January 2015 in our hospital were selected and randomly divided into experimental group and control group,29 cases in each group,the control group was treated with clomiphene citrate capsules,the patients in the experimental group were given Xuefuzhuyu pill baseed on the treatment in control group,treatment period for three menstrual cycles,after the end of treatment,the levels of serum sex hormone levels,fasting blood glucose,insulin levels,HOMA index,uterine endometrial thickness,ovulation and pregnancy were detected.Results After treatment,compared with control group,in the experimental group,the serum levels of LH and T were significantly lower,and the serum levels of FSH,E2 and P were significantly higher,the difference was statistically significant(P<0.05),the serum anti-Mullerian hormone(AMH)content in the experimental group was significantly lower,the difference was statistically significant(P<0.05),the serum levels of FINS and HOMA-IR were significantly lower in the experimental group,the difference was statistically significant(P<0.05),the endometrial thickness of patients in experimental group was significantly increased,the number of follicles and ovarian volume were significantly decreased,the difference was statistically significant(P<0.05),the ovulation rate and pregnancy rate in the experimental group was higher,the difference was statistically significant(P<0.05).Conclusion Xuefuzhuyu pill can significantly reduce the serum LH,T,FINS,AMH and HOMA-IR levels in patients with polycystic ovary syndrome,which can improve the serum FSH,P,E2 levels,regulate sex hormone secretion,reduce insulin resistance,improve the ovulation rate and pregnancy rate,compared to single use of citric acid clomiphene capsules effect is more ideal.

ObjectiveTo explore the association of smoking to the Aspirin and Clopidogrel antiplatelet in patients with stable angina after percutaneous coronary intervention (PCI). Methods241 smoking patients and 252 non-smoking patients underwent PCI for stable coronary artery disease, all patients had taken aspirin 100 mg/d for 7 d or more. The arachidonic acid (AA)- and adenosine diphosphate (ADP)-induced platelet aggregation were tested as they got in hospital. Then, they accepted Clopidogrel 300 mg as loading dose, continued with 75 mg/d for 3 d. The ADP-induced platelet aggregation were re-tested. ResultsThe incidence of aspirin resistance (AR) and aspirin semiresponder (ASR) was 19.1% in all the cases, and was 25.5% in smoking group, 14.3% in non-smoking group (P=0.027). Age (OR=3.79，95%CI: 1.77～8.12) and smoking (OR=1.98，95%CI: 1.18～4.43) were the independent risk factors of AR and ASR. The incidence of Clopidogrel resistance was 19.5% in all the cases, and was 13.2% in smoking group, 24.3% in non-smoking group (P=0.03). Smoking (OR=0.22，95%CI: 0.09～0.54) may reduce the risk of Clopidogrel resistance. ConclusionSmoking increased the risk of AR and ASR, but reduced the risk of Clopidogrel resistance.

Child ; Diarrhea ; diagnosis ; therapy ; Humans ; Practice Guidelines as Topic

Objective To investigate the relation between the expression of vascular endothelial growth factor (VEGF) and type Ⅳ collagen and the renal lesion of diabetes mellitus in diabetic rats. Methods Wistar rats were divided at random into normal control group(NC group) and diabetic model group(DM group), each group containing 20 animals. The rats models of diabetic mellitus were induced by streptozotocin(STZ). At the 8th week after induction, the expression levels of VEGF and type IV collagen in the kidney tissues in the two groups of rats were detected using immunohistochemistry. At the same time, the renal function of the rats was measured. Results At the 8th week,the expression levels of VEGF and type IV collagen of kidney tissues in DM group was much higher than those in NC group(P

Objective To explore the causes of accidental instability of SYSMEX XS-800i blood cell analyzer for WBC testing and their countermeasures.Methods Totally 10 pieces of specimen with high deviation were analyzed retrospectively, and the changes of DIFF-Y values of WBC were observed. Sysmex detergent was used to clean the pipelines including 4DL, 4DS and EPK pipes. Fluid path electromagnetic valve was checked and then repaired or replaced. Results It's proved that the results at the first time were not reliable, and there was significant differences between the results at the first and second times for DIFF-Y value, with P<0.01. The failures were eliminated after the above countermeasures were carried out.Conclusion WBC testing pipelines and electromagnetic valve of fluid path have to be cleaned periodically to eliminate the influence on DIFF-Y value of WBC and false increase of WBC counting.

Objective To observe the effects of Tangshenjiaonang (TSJN) on biochemistry, renal function and hemorheology of alloxan and achromycin induced diabetic nephropathy rats. Methods The diabetic nephropathy rats induced by alloxan and achromycin were divided into 5 experimental groups. compared with control group, to observe the changes of the indicators shown about. Results TSJN can significantly decrease the level of SCr, BUN, CCr, FIB, plasma viscosity and UAER (P