China ; Curriculum ; Education, Dental ; Oral Medicine ; education

Animals ; Atherosclerosis ; etiology ; genetics ; pathology ; China ; Coronary Disease ; pathology ; Genes, p53 ; Humans ; Point Mutation ; Risk Factors

Alveolar Process ; Housing ; Humans ; Incisor ; Maxilla ; Tooth Root

To investigate the mechanism of detrusor instability, using an apparatus to measure energy regulated tonicity and length of muscle strip in vitro , detrusor instability in bladder outlet obstruction (BOO) and spinal cord injuries (SCI) after pharmacological intervention was studied. The detrusor of both groups contracted under definite tension. Contraction of DI strips occurred under lower tension and under same tension the frequency of contraction was higher in DI detrusor than the normal one. There were no obvious changes when the detrusor strips were treated with M receptor antagonists, ATP or VIP. Muscarinic receptor agonist could increase the excitability of detrusor. The increase of detrusor excitability plays a major role in the occurrence of DI. The excitability is independent on neurogenic factors.

Since cardiopulmonary resuscitation(CPR)guidelines was constituted in 1974,it was adopted many times.The American Heart Association,in collaboration with the International Liaison Committee on Resuscitation(ILCOR),adopted new CPR science guidelines in January,2005.This article gives a short introduction of CPR,and showes the progress of several editions.

Objective To explore ICF-based measurement and statistical methods, and social support and service systems of intellectual disability. Methods ICF theories and approaches and literature review were applied. Results Based on the theories of function and disability in ICF, intellectual disability was characterized by the impairment of intellectual function and significant limitations in adaptive behavior, and onset before 18 years old. Based on the theories of intellectual disability in ICF, this study rebuilt the framework of intellectual disabili-ty, and modified the measure of intellectual disability by assessing the body function and measuring activities and participation to assess in-tellectual function and adaptive behavior, while analyzing the social support and service systems via environment factors. This study also dis-cussed related problems about the prevalence of intellectual disability. Conclusion New conceptual framework, measurement and statistical method of intellectual disability based on the theories and methods of ICF was discussed and the social support and service systems were in-tegrated into the environmental factor of intellectual disability.

Objective To establish an AGS cell line that stably expressing miR?126 and to study the effect of miR?126 on the proliferation and metastatic abilities of the AGS cell line in vitro. Methods AGS cells were infected by lentivirus with Lv?has?mir?126. After confirmation by RT?PCR ,CCK?8 and clone formation assays were used to evaluate the effect of miR?126 on AGS cell growth. Transwell migration and invasion assays were used to evaluate the effect of miR?126 on metastasis of AGS cells. Results We verified correct construction of recombinant AGS cells. RT?PCR confirmed mRNA levels of miR?126 existed significantly differences among the recombinant cell lines (P< 0.05). Proliferation assays and clone formation assays did not show a remarkable growth suppression in AGS?mir?126 cell line. However,transwell assay showed a notable acceleration in AGS?mir?126(P< 0.05). Conclusions We successfully constructed recombinant AGS cell line with stably high miR?126 expression level. MiR?126 could facilitate the metastasis of AGS cell in vitro.

Objective To explore the definition, structure, terminology, framework, and models of social support and services, and mea-surement of intellectual disability based ICF approach. Methods The ICF approach and definition and approach proposed by American Asso-ciation on Intellectual and Developmental Disabilities (AAIDD) were adopted. Results The characteristics of intellectual disability are sig-nificant limitations in both intellectual functioning and adaptive behavior as expressed in conceptual, social, and practical adaptive skills, and onset before 18 years old. The framework, domains and contents of services and support for intelligence disability were proposed, as well as the updated measurement of intelligence disability based on new framework and definition. Conclusion The new framework of intel-ligence disability, system of service and support, and measurement are in accordance with the bio-psycho-social model of disability of ICF. The new paradigm will provide framework and tool of measurement, rehabilitation, education, and social services for people with intelli-gence disability.