Leptin,the product of the obese gene,is a 16kDa secreted protein produced by white adipocytes.Because of its dual nature as a hormone and cytokine,leptin plays a role in regulating energy metabolism,inflam-marion,immune response,neuroendocrine and angiogenesis,and so on.The review focuses on the research and controversy of leptin's effect in osteoarthritis.

Objective To explore the morphology changes of spinal cord after nursing intervention on motor function repair spinal cord injuried rats. Methods 60 adult SD rats were randomly divided into normal control group, experimental control group, and experimental group ( n=20 for each group) . Each group were divided into four time phase points, that is 1 day, 7 days, 30 days and 60 days after spinal cord injury (n=5). The model of L4 plane with full transection of spinal cord were made in the rats in experimental control group and exper-imental group. Normal control group were of untreated normal rats, experimental control group were given routine nursing such as urination and defecation after spinal cord injury, and experimental group were given passive movement practices and muscle massage training twice a day (10 min each time) besides regular nursing. HE staining and immunohistochemistry method were applied to observe the morphology changes of spinal cord. Results In experimental control group and experimental group there was no significant changes in HE staning and NF-200 and GFAP immunohistchemistry staning in spinal cord section of rat at each time phase points, but compared to the normal control group, it was of significant difference. Conclusion There is no apparent change in morphology in injured spinal area after nursing intervention.

Objective To explore the effect of nursing intervention on degree of motor function recovery after spinal cord injury in rats. Methods 60 rats were randomly divided into three groups with 20 rats in each group. Group A was the control group,group B was the rou-tine nursing group,and group C was the nursing intervention group which was given nursing intervention such as muscle pressure,joint passive movement,and skin care. The ethology was evaluated by BBB score and inclined-plane score at different time points after spinal cord injury. Myoelectricity and wet weight of gastrocnemius muscle were observed at different time points after spinal cord injury through multi-channel physiological signal acquisition system and electronic weighing scales. Results BBB score and inclined-plane score were basically the same. Compared with group B,hind limb function of group C was significantly improved,but it was obviously lower than the control group. Amplitude of gastrocnemius myoelectrical fibrillation in group C was higher than that in group B and gastrocnemius muscle wet weight decrease in group C was lower than that in group B. Conclusion Nursing intervention can delay the speed of gastrocnemius muscle atrophy,improve motor function,and promote the recovery of partial function after the spinal cord injury in rats.

Non-receptor tyrosine kinase c-Abl has been implicated in the regulation of the cell cycle,adhesion, apoptosis and DNA damage responses.Its excessive activation is related with the development of chronic myeloid leukemia, and the relationship between c-Abl and leukemia is in depth and detailed research.In contrast to leukemia, the research between c-Abl and solid tumors is just at the early stage.This paper briefly reviews research progress of the c-Abl in solid tumors.

Objective To investigate the effect of informational support on disease uncertainty in liver cancer patients undergoing interventional therapy. Methods Sixty patients of liver cancer patients undergoing interventional therapy were randomly divided into the intervention group and the control group with 30 in each.The control group was treated with general treatment and care. The patients in the intervention group were given general treatment and care with a series of informational support interventions. Patients in the two groups were measured by uncertainty in illness scale (MUIS) at the day of admission,before operations and discharged from hospital. The measurement results were statistically analyzed. Results There was significant decrease about disease uncertainty scores both on the day before operation and the day before discharge in the intervention group compared to the day of admission. The decreasing score of uncertainty in illness in the intervention group was significantly greater than the control group on the day before operation and the day before discharge. Conclusions A series of informational support interventions could significantly reduce the diseases uncertainty in liver cancer patients undergoing interventional therapy.

Cholesterol ; metabolism ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Metabolic Diseases ; prevention & control ; Phytotherapy

Objective　To study the radiographic findings in the diagnosis of pulmonary lymphoma and pseudolymphoma. Methods　Eight patients with pulmonary lymphoma and 2 with pseudolymphoma were examined by X-ray film, tomography, and CT. Results　Single or multiple nodules or masses were observed in 8 patients with pulmonary lymphoma, shaggy borders or halo of ground-glass attenuation in 7 patients, 2 patients had multiple patchy infiltrates bilaterally, 2 had diffuse interstitial infiltrates and 1 had miliary nodules. Multiple consolidations with air bronchogram and without hilar and mediastinal lymphadenopathy were observed in 2 patients with pulmonary pseudolymphoma. Conclusion　Radiographic findings of pulmonary lymphoma were varied, the most common findings were the nodules or masses with shaggy borders or halo of ground-glass attenuation. The specific findings of pulmonary pseudolymphoma were multiple consolidations with air bronchogram and without hilar and mediastinal lymphadenopathy. The final diagnosis relied on pathology.

AIM: To assess the effect of two different suture methods on the degree of pain and corneal epithelium healing condition after pterygium excision combined with autologous conjunctival flap graft transplantation. ·METHODS: Retrospective case-series study. According to the suture method, a total of 92 patients (92 eyes) with pterygium who received treatment in the First Affiliated Hospital of Huzhou University from June 2015 to June 2016 were divided into two group. There were 48 patients ( 48 eyes) in Group A were received intermittent suture, and 44 patients ( 44 eyes ) in Group B were received continuous interlocking suture. The degree of pain after surgery were evaluated between the two groups at 2h, 1d and 1wk after surgery by visual analogue score ( VAS). The healing status of corneal epithelium were observed between the two groups at 1d and 1wk after surgery by fluorescent staining. ·RESULTS: There was no significant difference in the average pain value 2h after surgery between Group A and Group B (P>0. 05). The average pain values 1d and 1wk after surgery in Group B was lower than that in Group A respectively (P<0. 01). Mean scores of corneal epithelium healing condition at 1wk were significantly better in Group B than in Group A (0. 54 ± 0. 32 vs 0. 86 ± 0. 34, P<0. 05), while not significantly different at 1d after the surgery (4. 04±1. 46 vs 4. 30±1. 42, P>0. 05). · CONCLUSION: Compared to intermittent suture, continuous interlocking suture can release pain response after pterygium excision combined with autologous conjunctival flap graft transplantation and promote the healing status of corneal epithelium.

Objective To explore the variation of serum galectin-3 and its correlation with ventricular remodeling in children with chronic cardiac failure (CHF). Methods Forty-ifve children with CHF were included and divided into cardiac function II group (n=10 ), III group (n=18 ), and IV group (n=17 ) according to the severity of CHF. The subjects were also divided into endocardial fibroelastosis (EFE) group (n=21 ) and dilated cardiomyopathy (DCM) group (n=24 ) according to primary disease. Thirty health children were included as control group. The level of serum galectin-3 was detected by ELISA. The level of serum NT-pro BNP was measured by radio immunoassay. The index of ventricular remodeling was detected by ultrasonic cardiogram. The correlation of the level of serum galectin-3 with ventricular remodeling and the level of serum NT-pro BNP were analyzed. Results In 45 children ( 19 males and 26 females) with CHF, the mean age was 3 . 42 ± 1 . 89 years. The levels of serum galectin-3 and NT-pro BNP were higher in cardiac function II group, III group, and IV group than those in control group (all P?0 . 05 ). Spearman rank correlation analysis showed that the level of serum galectin-3 was positively correlated with the left ventricular end diastolic diameter, the left ventricular mass, the left ventricular mass fraction, and the level of serum NT-pro BNP (all P?

Epidermal growth factor receptor (EGFR), an important target for tumor targeted therapy, is overexpressed / mutated in the majority of tumors. Immune cells modified by chimeric antigen receptor , including T cells, NK cells and so on, is a new technology in recent years, which has showed an unique advantage in the treatment of malignant tumors. In this paper, the research progress of T cells and NK cells modified with chimeric antigen targeting for EGFR and its mutants will be reviewed.