Objective To investigate the clinical and pathological manifestation of acute kidney injury ( AKI) following infusion of clindamycin .Methods 12 patients were diagnosed as the infusion of clindamycin induced AKI .The clinical and pathological manifestations of these patients were investigated .Results 8 patients (66.7%) had episodes of gross hematuria .Oliguria and anuria was in 6 patients(50.0%).The histological diagnosis of acute interstitial nephritides(AIN) included 5 patients(83.3%).The immunofluorescent examination was negative in all cases .Renal replacement therapy were delivered to four patients .Prednisone was prescribed to 7 patients .All of patients discharged from the hospital and free of renal replacement therapy .The level of serum creatinine decreased to normal 6 months later .Conclusion Most of the AKI associated with clindamycin was oliguria with episodes of gross hematuria ,while the manifestations of skin rash were uncommon .The histological changes revealed AIN .The recent prognosis was relatively good ,but the long-term prognosis should be investigated .

Objective To investigate the distribution of the vesicular glutamate transporters (VGluTs), VGIuT1 and VGIuT2, in the spinal cord in multiple species, including rat, cat and monkey. Methods An immunohistochemical technique was used in the present study. Results VGluTs were observed in the gray matter of the spinal cord of rat, cat and monkey. VGluTl-immunoreactivity (VGluT1-IR) was most intense in the inner part of lamina Ⅱ(Ⅱi) and the medial parts of laminae Ⅲ-Ⅵ of the spinal dorsal horn; weak in lamina Ⅰ and outer part of lamina Ⅱ(Ⅱo); moderate in other parts in the rat and cat. The laminar distribution of VGluT1-IR in the spinal cord in the monkey is different from those in the rat and cat. The VGluT1-immunopositive product was intense in laminae Ⅰ, Ⅱi, Ⅲ and the medial parts of laminae Ⅳ-Ⅵ of the spinal dorsal horn; weak to absent in lamina Ⅱo and the lateral parts of laminae Ⅳ-Ⅵ of the dorsal horn. In the spinal anterior horn of monkey, the VGluT1-immunoreactive profiles were observed sparsely just in lamina Ⅸ, not in other laminae. At the same time, some scattered immunoreactive profiles were present in the white matter, particularly at the medial parts of the dorsal column in monkey, but not in rat and cat. On the other hand, VGluT2 immunoreactivity (VGluT2-IR) was moderately present throughout the gray matter, it was most dense in laminae Ⅰ-Ⅱ and Ⅹ, and weak in the medial parts of the deep spinal dorsal horn (laminae Ⅲ-Ⅵ) in the three species. The VGluT2-immunopositive product was very sparse in the lateral parts of the deep spinal dorsal horn of the monkey. In the lateral spinal nuclei of the rat, moderate VGluT2-immunopositive product could be seen, but not in the cat and monkey. In three species, both VGluT1- and VGluT2-IR showed a punctuate distribution. Conclusion The present results indicated that VGluT1 and VGluT2 were expressed in the spinal cord in all species examined but differentially distributed in a species-specific manner, and they might play an important role in the activities of the excitatory neurons in the spinal cord of rat, cat and monkey.

Objective To explore the characteristics of TCM syndrome of vertigo. Method Patients of vertigo need to fill a form about the symptoms of TCM, and then analyze the frequence and percentage of the symptoms and the syndromes with SPSS software. Result Except vertigo or dizziness, the common accompanied symptoms were distractedness, feeling thirsty, tinnitus, poor memory, afraid of cold and vomiting, etc. There were 26 syndromes, and the top 5 of which are yin-deficiency of liver and kidney, wind stirring, phlegm blocking, qi-deficiency of spleen and blocking qi of liver. Conclusion The characteristics of syndrome of these patients of vertigo were same as the theory of TCM. The better way to find the characteristics of syndrome of vertigo still need to be explored.

Vertigo is a kind of patients' subjective feelings. The severity of vertigo is closely related to many factors. But we are short of a well accepted quantitative evaluation method capable of accurately and comprehensively evaluating vertigo in clinics. Reducing the onset of vertigo, enhancing the re- covery of equilibrium function, and improving the quality of life of vertigo patients should be taken as the focus of evaluating therapeutic effects. As for establishing a Chinese medical effectiveness evaluation system for vertigo, we believe we should distinguish different "diseases". We could roughly identify it as systemic vertigo and non-systemic vertigo. For systemic vertigo, the efficacy of vertigo could be comprehensively evaluated by UCLA vertigo questionnaire or dizziness handicap inventory combined with equilibrium function testing indices. But for non-systemic vertigo, the efficacy of vertigo could be comprehensively evaluated by taking UCLA vertigo questionnaire or dizziness handicap inventory as main efficacy indices. Secondly, we should analyze different reasons for vertigo, choose symptoms and signs in line with vertigo features as well as with Chinese medical theories, and formulate corresponding syndrome effectiveness standards according to different diseases. We should not simply take syndrome diagnosis standards as efficacy evaluation standards.
China ; Dizziness ; diagnosis ; Humans ; Quality of Life ; Surveys and Questionnaires ; Vertigo ; diagnosis

Objective To evaluate the clinical outcomes of the reformed microlumbar discectomy preserving partial ligamentum flavum to prevent lumbar spinal instability and .scar tissue oppression and adhesion after operation. Methods A prospective, randomized, controlled clinical study was conducted.The patients with unilateral lumbar disc herniation were randomly divided into two groups. The control group (41 cases) underwent classic mien)lumbar disceetomy,.and the test group (44 cases) underwent the same procedure but with a curved incision on the lumbo-dorsa fascia and with partial preservation of the ligamentum flavum. Visual analog scale (VAS) scores and Oswestry scale scores were used to appraise the outcomes. Results Chnieal parameters were significantly improved after the operation in two groups. In the test group the postoperative VAS scores showed a less intensity of pain after the operation than that in the control group, and this superiority disappeared 1 year after the operation. After the operation, the VAS scores in the test group and contnd group were (1.8±0.6) and (3.8±1.3) scores at 3 days (P <0.05), (1.3±0.6) and (3.5±2.1) scores at 12 weeks (P<0.05), and (1.9±0.6) and (2.8±1.7) scores at 1 year (P>0.05) respectively. After the operation, the Oswestry scale scores in the test group and control group were (18.2±6.6) and (34.4±11.8) scores at 12 weeks (P <0.05), (12.0±9.2) and (22.6±10.0) scores at 1 year (P<0.05) respectively. In both groups, there was no patient who had recurrence of intervertebral disc hernia and reoperation. Conclusions Minimally invasive discectomy has satisfactory clinical outcomes,however, with partial preserved ligamentum flavum shows a less intensity pain and a better lumbar function state. Preserving the ligamentum flavum is helpful to prevent the fibrosis-related complication and to preserve the stabihty of the spine.

Objective To investigate the composition and diversity of acaroid mite community in the house in Xuancheng area in Anhui province.Methods The dust samples from 4 sites selected in each house were collected in June-July,2006,acaroid mites were isolated,counted and identified.Results 3 386 acaroid mites were obtained,belong to 6 families,12 genera and 14 species.The species richness index Rmargalef for the four habitats ranged from 0.73 to 1.75,while the species diversity index(Shannon-Wiener index) ranged from 1.36 to 1.87 and Pielou index ranged from 0.70 to 0.92.Conclusion The results of the present paper show that the habitat condition is the main factor that can directly influence the community structure and diversity of acaroid mites in the houses and the human activity is also an influencing factor to be reckoned with.

Objective To analyze the efficacy and safety of same-session bilateral and staged unilateral flexible ureteroscopic lithotripsy ( FURL) with holmium laser for the treatment of upper urinary system stones . Methods Clinical data of 29 patients who underwent same-session bilateral FURL ( same-session group ) and 20 patients who received staged unilateral FURL ( staged group ) from September 2012 to May 2015 at this hospital were analyzed retrospectively .The overall operation time ,overall hospital stay , stone free rate (SFR) and overall complication rate were compared between the two groups . Results The operations were successfully completed in both groups.The overall operative time was significantly longer for staged unilateral FURL than bilateral FURL [(71.0 ± 19.0) min vs.(112.6 ±26.8) min, t=-6.366, P=0.000].The overall hospital stay was slightly longer for staged unilateral FURL than bilateral FURL [(6.9 ±3.6) d vs.(8.4 ±2.1 ) d, t=-1.674, P=0.101].The four-week postoperative SFR for bilateral FURL and staged unilateral FURL were 79.3%(23/29) and 80.0%(16/20), respectively (χ2 =0.000, P=1.000).The overall complication rate was slightly higher for bilateral FURL [20.7% (6/29) vs.15.0% (3/20), χ2 =0.017, P=0.896]. Conclusion Same-session bilateral flexible ureteroscopic holmium laser lithotripsy is a safe and effective treatment for bilateral upper urinary system stones in select patients .

Objective To investigate the effects of nicergoline on expressions of 5-hydroxytryptamine 1A receptor (5-HT1AR), D2 dopamine receptor (D2DR),α2A adrenaline receptor (α2AAR) in the hippocampal CA1 region and the serum level of apolipoprotein E4 (ApoE4) in a rat model of vascular depression (VD) . Methods Forty-eight male Sprague-Daw ley rats w ere randomly al ocated into a normal control group, a model group, fluoxetine group, a low-dose nicergoline group, a medium-dose nicergoline group, and a nicergoline high-dose group ( n=8 in each group). A rat model of VD w as induced by the ligation of bilateral common carotid arteries combined w ith chronic unpredictable mild stress (CUMS) plus single housing. The rats did not conduct CUMS or single housing in the normal control group, and the rats in the model group conducted CUMS and single housing. The rats in the fluoxetine group w ere given fluoxetine 1.3 mg/(kg· d) for gastric lavage for 3 w eeks at the beginning of CUMS and single housing. The rats in the low -, medium-and high-dose nicergoline groups w ere given nicergoline 0.9, 1.9 and 3.8 mg/(kg· d), respectively for gastric lavage for 3 w eeks at the beginning of CUMS and single housing. The normal control group and the model group w ere given equal volume of distil ed w ater for gastric lavage, once a day for 3 w eeks. Depression-like behavior w as evaluated using sucrose solution consumption and open-field test. Immunohistochemical staining and Western blot were used to detect the expressions of 5-HT1AR, D2DR, andα2AAR in the hippocampal CA1 region. Enzyme linked immunosorbent assay w as used to detect serum ApoE4 level. Results Before CUMS, the scores of horizontal and vertical movement and sucrose solution consumption in the model group, the fluoxetine group and each nicergoline group w ere decreased significantly compared w ith the normal control group (al P<0.01);w hile at 21 days after CUMS, those in the fluoxetine group and the nicergoline medium-and high-dose groups w ere significantly higher than those in the model group (al P<0.05). There w ere no significant differences betw een the fluoxetine group and each nicergoline group. The expression levels of 5-HT1A R, D2DR, α2A AR, and the serum ApoE4 in the model group, the fluoxetine group, and each nicergoline group w ere significantly higher than those in the normal control group. Those of the fluoxetine group and the nicergoline medium -and high-dose groups were significantly lower than the model group (al P<0.01), while there were no significant differences betw een the fluoxetine group and each nicergoline group. Conclusions Nicergoline can improve the depression-like behavior in VD rats. Its mechanism may be associated w ith the dow nregulation of 5-HT1AR, D2DR, α2AAR expressions and serum ApoE4 level.

Objective To investigate the safety and feasibility of Minocycline Hydrochloride Ointment and metronidazole membrane in the treatment of periodontal abscess.Methods80 cases of patients with periodontal abscess in our hospital from May 2014 to May 2016 were selected, these patients were randomly divided into Minocycline Hydrochloride Ointment group (n=40) and metronidazole membrane group (n=40) two groups, the periodontal probing depth, gingival bleeding index, plaque index, attachment loss, clinical efficacy, the incidences of adverse reactions and recurrence of the two groups were statistically analyzed.ResultsThe periodontal probing depth, gingival bleeding index, plaque index, attachment loss of the Minocycline Hydrochloride Ointment group were significantly lower (P<0.05), the total treatment efficiency 95% (38/40) was significantly higher than the metronidazole membrane group 77.5% (31/40) (P<0.05), the recurrence rate 2.5% (1/40) was significantly lower than the metronidazole membrane group 15% (6/40) (P<0.05), but the difference of the incidences of adverse reactions 10% (4/40), 7.5% (3/40) between the two groups was not significant.ConclusionMinocycline Hydrochloride Ointment metronidazole membrane in the treatment of periodontal abscess has higher safety and feasibility than metronidazole membrane, so is worthy of promotion in the clinical.

Objective To improve the therapeutic efficacy of cervical spondylotic myelopathy (CSM) and reduce the complications by anterior cervical locking plate system (ACLPs).Methods 78 patients with CSM were treated with ACLPs.Thoughtful preparation and careful observation were given before and after the operation.Result All the cases obtained excellent results postoperatively according to the JOA score system except one dead.Conclusion ACLPs is a promising method for the treatment of CSM;careful preoperative preparation and postoperative observation can improve the efficacy and reduce the complications.