1.Inferior vena cava filter placement for the prevention of pulmonary embolism and the complications related to the filter placement
Jianming LI ; Guangzhi JIA ; Xiaojun QIN
Journal of Interventional Radiology 2009;18(12):900-903
Objective To investigate the effects of inferior vena cava (IVC) filter placement for the prevention of fatal pulmonary embolism and to discuss the management of complications related to the filter placement. Methods Seventy patients with proved deep vein thrombosis of lower extremity underwent inferior vena cava filter placement. A total of 72 IVC filters were implanted, which included 20 Trap Ease filters, 31Vena Tech filters, 13 retrievable OptEase~(TM) filters and 8 Tempo Ⅱ filters. One filter was deployed above the orifice of renal vein and the remaining 71 were deployed below the orifice of renal vein. Results All the patients were followed up for 8-72 months after the procedure. During the follow-up period no fatal pulmonary embolism occurred except that some complications related to the filter placement occurred in 6 cases.Conclusion Inferior vena cava filter placement can effectively prevent the occurrence of pulmonary embolism. Of course, this treatment should be strictly applied according to the indications.
2.Clinical observation of ruangan suopi tablet in treating chronic hepatitis B caused liver cirrhosis.
Jia-fu LI ; Hui-qin ZHANG ; Peng-hui SHI
Chinese Journal of Integrated Traditional and Western Medicine 2002;22(3):188-189
Adult
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Drugs, Chinese Herbal
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therapeutic use
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Female
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Hepatitis B, Chronic
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complications
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drug therapy
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Humans
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Liver Cirrhosis
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drug therapy
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etiology
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Male
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Middle Aged
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Phytotherapy
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Tablets
3.Current views on surface enhanced Raman spectroscopy in microbiology.
Xiaoxiao JIA ; Jing LI ; Tian QIN ; Aihua DENG ; Wenjun LIU
Chinese Journal of Biotechnology 2015;31(5):611-620
Raman spectroscopy has generated many branches during the development for more than 90 years. Surface enhanced Raman spectroscopy (SERS) improves SNR by using the interaction between tested materials and the surface of rough metal, as to quickly get higher sensitivity and precision spectroscopy without sample pretreatment. This article describes the characteristic and classification of SERS, and updates the theory and clinical application of SERS. It also summarizes the present status and progress of SERS in various disciplines and illustrates the necessity and urgency of its research, which provides rationale for the application for SERS in microbiology.
Microbiology
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Spectrum Analysis, Raman
4.The characters of non-professional drivers' stress
Yanzhang LI ; Jie JIA ; Lian YIN ; Qin TANG
Chinese Journal of Behavioral Medicine and Brain Science 2011;20(1):62-64
Objective To explore the characters of non-professional drivers' stress. Methods Two hundred and sixty-four non-professional drivers in Chengdu city were randomly investigated by Driver Stress Inventory(DSI). One hundred and five professional drivers were as control group. Results ①Compared with professional drivers,non-professional drivers scored higher in thrill seeking, cognitive fatigue and aggression (non-professional drivers :4.63±1.49,5.12±1.56,5.65±1.42; professional drivers: 3.60 ± 2.04,3.97 ± 2.02,4.56 ±1.84, P < 0.01 ) ,and lower in hazard monitoring, driving anxiety and physiological fatigue (non-professional drivers:7.04±1.48,6.44±1.50,5.78±1.75; professional drivers:7.89 ± 1.45,6.99 ± 1.28,6.45 ± 2.37, P <0.01 ). ②Non-professional drivers' stress had significant differences in gender, age, marital state and driving experiences (P<0.05). The male drivers scored higher in thrill seeking, aggression and physiological fatigue (male:4.79±1.53,6.78±1.46,5.94 ± 1.80; female:4.32±1.37,5.80±1.37,5.50 ± 1.61, P < 0.05 ). Compared with other age driver groups, the 20 ~29 driver group scored higher in cognitive fatigue (5.44 ± 1.38 ), and lower in hazard monitoring(6.77±1.44) ,driving anxiety (6.03 ±1.46). Compared with unmarried drivers, married non-professional drivers scored higher in hazard monitoring and driving anxiety ,and lower in cognitive fatigue( married drivers:7.23±1.43,6.65±1.48,4.88±1.6; unmarried drivers :6.77±1.47,6.06±1.43,5.59±1.36, P <0.05 ). The non-professional drivers who drove more than 20 thousand kilometers scored higher in driving anxiety (6.89±1.41). Conclusion The non-professional drivers' stress isn' t optimistic, and influenced by their gender,age, marital state and driving experiences. Stress management should pay attention to them.
5.Diagnostic value of macrophage activity MRI in rat model of multiple sclerosis
Haiqin ZHANG ; Kuncheng LI ; Chunshui YU ; Jia MA ; Wen QIN
Chinese Journal of Radiology 2010;44(10):1089-1093
Objective To investigate the value of macrophage activity imaging (MAI) in the diagnosis of brain and spinal cord lesions in rat model of multiple sclerosis(MS). Methods Twenty LEW rats were divided into 15 model rats and 5 control rats. MS animal model, experimental autoimmune encephalomyelitis (EAE) was induced by the injection of peptide 35-55 of myelin oligodendrocyte glycoprotein ( MOG35-55 ). MRI was performed on the third day of the acute stage of disease. The brain and spinal cord of rats were scanned by 3.0 T MR scanner( Siemens Trio Tim) with quadrature wrist joint coil.The T2W and T1 W images, Gadolinium enhanced T1 W images in 3D volume were obtained respectively. The MAI were obtained at 24 hours after intravenous injection of ultra small superparamagnetic iron oxide (USPIO) as contrast medium on T2WI. The workstation with special software was used for the reconstruction images of brain and spinal cord of rat in multiple orientations. Results Fifteen MOG35-55-EAE rats model of MS were successfully induced. The great majority lesions of central nervous system in acute stage were located in the brain( 58/63 ) and less in the spinal cord (5/63). The main manifestation of EAE lesions presented was hyperintensity on T2 WI and hypointensity on T1 WI, and some lesions had enhancement after Gd-DTPA injection. The EAE lesions presented as hypointensity on MAI images, but some of them were found to be isointensity on T2 WI. The enhancement pattern was discrepant between USPIO and Gd-DTPA.The sensitivity of depicting lesions of MOG35-55-EAE rat at acute stage were higher on T2WI ( 14/15 ) and MAI ( 13/15 ), and the detection rate was 100% ( 15/15 ) if they were combined. Gd-DTPA enhanced T1 WI had a lower sensitivity (7/15). All the MAI findings were negative in the control rats. Conclusions MAI can complement the drawback of conventional MRI techniques by continuously monitoring the inflammatory activity of EAE lesions, and it could raise the detection rate of EAE lesions by combining with T2WI. Gd-DTPA enhanced T1 WI monitors the breakdown of the blood brain barrier. MAI and Gd-DTPA enhanced MR imaging are complementary in the diagnosis and monitoring of EAE lesions.
6.Comparison of cardiac function parameters in gated myocardial SPECT determined by filtered backprojection and OSEM reconstruction methods
Jia-jun, LI ; Yue-qin, TIAN ; Zuo-xiang, HE
Chinese Journal of Nuclear Medicine 2011;31(3):183-186
Objective To compare the cardiac function parameters in gated SPECT determined by filtered back projection (FBP) and OSEM reconstruction methods. Methods One hundred and forty-four patients underwent 99Tcm-MIBI gated-SPECT imaging studies. The parameters LVEF, EDV and ESV, were derived using quantitative gated SPECT (QGS), four-dimensional model SPECT (4D-MSPECT) and emory cardiac toolbox (ECToolbox) softwares. Each image was reconstructed by FBP or OSEM. Bland-Altman analysis and paired t-test were applied to evaluate those parameters. Results Correlation coefficients for LVEF, EDV and ESV between FBP and OSEM methods were all more than 0.93 (all P<0.001). EDV calculated by FBP was lower than that by OSEM using QGS software, but became the opposite when using 4D-MSPECT and ECToolbox softwares. (QGS: (82.2±39.1) ml vs (83.5±40.8) ml, t=-2.53, P<0.05; 4D-MSPECT: (93.5±46.9) ml vs (88.8±45.2) ml, t=5.95, P<0.01; ECToolbox: (106.4±51.1) ml vs (100.8±49.0) ml, t=3.99, P<0.01). ESV calculated by FBP was higher than that by OSEM using 4D-MSPECT software (4D-MSPECT:(37.5±41.4) ml vs (34.8±37.6) ml, t=3.92, P<0.01). LVEF calculated by FBP was lower than that by OSEM using QGS software ((62.1±16.9)% vs (63.1±16.1)%, t=-3.14, P<0.05), but higher than that by OSEM using ECToolbox software ((74.1±18.8)% vs (71.3±17.1)%, t=5.28, P<0.01). Conclusion Generally, cardiac functional parameters based on FBP and OSEM construction methods correlated well, although they might have singnificantly different results.
7.LC-MS/MS method for quantification and pharmacokinetic study of gabapentin in human plasma.
Zhili XIONG ; Jia YU ; Jifen HE ; Feng QIN ; Famei LI
Acta Pharmaceutica Sinica 2011;46(10):1246-50
A sensitive, rapid and specific liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for quantification of gabapentin in human plasma has been developed. After a single plasma protein precipitation with methanol, gabapentin and metformin (internal standard) were chromatographed on a Inertsil ODS-3 column (50 mm x 2.1 mm ID, 3 microm) with mobile phase consisting of methanol-0.2% formic acid aqueous solution (80:20, v/v) at a flow-rate of 0.2 mL x min(-1). Electrospray ionization (ESI) source was applied and operated in the positive ion mode. Multiple reaction monitoring (MRM) mode with the transitions of m/z 172 --> m/z 154 and m/z 130 --> m/z 71 were used to quantify gabapentin and metformin, respectively. The run time was 2.2 min. The linear calibration curve was obtained in the concentration range of 40.8-8.16x10(3) ng x mL(-1). The lower limit of quantification was 40.8 ng x mL(-1). The intra- and inter-day precision (RSD) was less than 12%, and the accuracy (RE) was within +/-6.4% calculated from quality control (QC) samples. The method was used to determine the concentration of gabapentin in human plasma after a single oral administration of 600 mg gabapentin capsule to 20 healthy male Chinese volunteers. The method was proved to be selective, sensitive, rapid and suitable for pharmacokinetic study of gabapentin in human plasma.
8.Relationships of driving coping styles with driving behaviors and road accidents of drivers
Yanzhang LI ; Jie JIA ; Lian YIN ; Qin TANG
Chinese Journal of Behavioral Medicine and Brain Science 2012;21(1):73-75
ObjectiveTo explore the relationships of driving coping styles with driving behaviors and road accidents of drivers.MethodsThree hundreds and thirty-seven drivers were randomly surveyed by Driving Coping Questionnaire ( DCQ),Driver Behavior Questionnaire (DBQ).Results ( 1 ) Except avoidance coping style,confrontive coping and emotion-focused coping were correlated positively with the three driving behaviors ( r =0.18 ~ 0.56,P < 0.01 ),and positive appraisal coping had negatively correlations with them (( r =-0.34 ~-0.41,P<0.01 ).(2)Positive appraisal coping,confrontive coping and emotion-focused coping could predict 33.5% of error behaviors and 23.5% of slip behaviors.And confrontive coping and positive appraisal coping could predict 40.2% of speeding and violation behaviors.(3) Compared with safety drivers,accident drivers had significantly differences in confrontive coping in mild and moderate crashes( t=-2.75,2.80,P< 0.01 ).ConclusionDriving coping styles are the important factors influencing drivers' behaviors and road safety.
9.NMR-based analysis of water soluble extracts of different Astragali Radix.
Dong TIAN ; Zhenyu LI ; Shengci FAN ; Jinping JIA ; Xuemei QIN
Acta Pharmaceutica Sinica 2014;49(1):89-94
Water soluble extract (WSE) is an important index for the quality evaluation of Astragali Radix (AR). In this study, the WSE of the wild AR from Shanxi province (SX) and the cultivated AR from Gansu Province (GS) were compared. The WSEs of two types of AR were determined according to the appendix of Chinese pharmacopoeia. Then the WSEs were subjected to NMR analysis, and the obtained data were analyzed using HCA, PCA, OPLS-DA, microarray analysis, and Spearman rank analysis. In addition, the Pearson correlation of differential metabolites were also calculated. The results showed that the WSE content of GS-AR (37.80%) was higher than that of SX-AR (32.13%). The main constituent of WSE was sucrose, and other 18 compounds, including amino acids, organic acids, were also detected. Multivariate analysis revealed that SX-AR contained more choline, succinic acid, citric acid, glutamate, taurine and aspartate, while GS samples contained more sucrose, arginine and fumaric acid. In addition, the Pearson correlations between different metabolites of the two types of AR also showed apparent differences. The results suggested that the WSE of two types of AR differs not only in the content, but also in the chemical compositions. Thus, the cultivation way is important to the quality ofAR. This study supplied a new method for the comparison of extract of herbal drugs.
10.MRI of the central nervous system in rats of multiple sclerosis with clinical whole body MR scanner
Haiqin ZHANG ; Kuncheng LI ; Chunshui YU ; Wen QIN ; Jia MA
Chinese Journal of Medical Imaging Technology 2009;25(10):1729-1732
Objective To explore the feasibility of using clinical whole body MR scanners to investigate the intravital visibility of central nervous system (CNS) lesions in rats of multiple sclerosis (MS). Methods Ten Lewis rats were injected with the peptide 35-55 of myelin oligodendrocyte glycoprotein to make the model of MS. On a Siemens Sonata 1.5T MR scanner equipped with a flexible surface coil, rats brain and spinal cord were examined using T2-weighted and T1-weighted imaging with slice thickness of 1-2 mm. On a Siemens Trio Tim 3.0T MR-scanner equipped with a quadrature wrist coil, rats were examined using T2WI, T1WI and Gd-DTPA enhanced T1WI 3-dimensional imaging with voxel size up to 0.06-0.08 mm~3. Rat brain and spinal cord images in multiple orientations were reconstituted with special software in workstation. Results T2WI and T1WI of the lesions in MS rat brain with high spatial and contrast resolution could be obtained with clinical 3.0T MR scanner, though the image resolution of spinal cord was relatively low. The resolution of 1.5T MR was lower than that of 3.0T. Plaques in CNS of MS rats presented as hyperintense areas on T2WI and hypointense areas on T1WI. Contrast enhancement was observed as hyperintense on T1WI. Conclusion High quality images of CNS lesions canbe obtained with clinical 3.0T MR-scanner in MS rat, which offers a noninvasive access for studying CNS diseases in the rats.