ObjectiveTo evaluate portal vein chemotherapy for the treatment of hepatocellular carcinoma with portal vein tumor thrombi(PVTT).MethodsFourty five HCC patients with tumor thrombi in the main portal vein or the first branches undergoing surgical resection were divided into two groups receiving postoperative intraarterial and intraportal chemotherapy (21 cases), and intraarterial chemotherapy only (24 cases).ResultsThe survival rates of 6,12,18 months was 86%, 76% and 48% in the treatment group compared with 75%, 58% and 33% in the control group respectively. There were significant difference between the two groups.Conclusion Hepatectomy for HCC with removal of tumor thrombi and transcatheter hepatic arterial and portal vein chemotherapy is an effective treatment for HCC with PVTT.

Objective To assess the therapeutic strategies and prognostic factors that influence clinical outcome of malignant fibrous histiocytoma (MFH) of the abdomen. Methods Between Jul 1980 and Nov 2003, 51 intraabdominal MFH patients undergoing resection were retrospectively analyzed. Results Postoperative recurrence developed in 35 patients, with local recurrence in 15 (29. 4% ) , distant metastasis in 20, including lung metastasis in 8 ( 15. 7% ) , liver metastasis in 4(7. 8% ) , and bone metastasis in 6 ( 11. 7% ). The 1-, 3- and 5-year disease-free survival rate was 70. 6% , 43. 1% and 29. 4% , respectively, and the 1-, 3- and 5-year cumulative survival rate was 74. 5% , 52. 9% and 31. 4% , respectively. Conclusions Intraabdominal MFH is a rare entity with high biological aggressiveness and high metastasis potential. Surgical resection has generally been accepted as the treatment of choice for MFH, at the same time, there appears to be a role for radiation therapy, in combination with surgery for better local control, particularly in high-grade lesions.

Objective To evaluate operative efficacy in regional pancreaticoduodenectomy with mesenteric-portal vein resection and graft reconstruction using iuternal jugular vein for pancreatic head carcinoma.Methods From Jan 2000 to Jan 2003,6 patients with pancreatic head tumors and mesenteric- portal vein involvement underwent regional pancreatieoduodenectomy with mesenteric-portal vein reseetion and vascular reconstruction using internal jugular vein.Results Surgery was successful in all 6 patients. Postoperative pathology revealed that mesenteric vein or portal vein were invaded by tumor in all cases. Survival time ranged from 17 to 49 mouths.The median survival was 23.4 months.Two cases have survived over 3 years and one of them was alive 49 months postoperatively without recurrence.Conclusion The regional pancreaticoduodenectomy with tumor invaded mesenteric-portal vein resection and graft reconstruction by using internal jugular vein renders a longer survival in metastasis-negative patients of pancreatic head adenocarcinoma.

OBJECTIVE:To investigate the antiviral effect of Gankeshuangqing capsule on virus infected mouse model.METHODS:The virus infected mouse model was established by administering influenza virus through nose,and then Gankes_ huangqing capsule was given intragastrically,the antiviral effect was observed by experiment of viral pneumonia and viral multiplication.RESULTS:Gankeshuangqing capsule could significantly reduce the lung indices,and lessen the pulmonary histopathological change;It also significantly inhibit virus multiplication in lungs of mouse.CONCLUSION:Gankeshuangqing capsule has a strong anti-influenza effect on virus infected mouse model.

Filamentous fungi have been used in industrial fermentation extensively. Based on non-phosphorylating electron transport process, alternative respiration pathway (ARP) acts as an energy overflow, which can balance carbon metabolism and electron transport, allow the continuance of tricarboxylic acid cycle without the formation of ATP, and permit the turnover of carbon skeletons. Alternative respiration pathway also plays an important role in the stress response of fungi and the physiological function of conditioned pathogen. Alternative oxidase (AOX) is the terminal oxidase responsible for the activity of alternative respiration pathway, which exists widely in higher plants, parts of fungi and algae. Owing to the property that alternative oxidase (AOX) is sensitive to salicylhydroxamic acid (SHAM) and insensitive to conventional inhibitors of cytochrome respiration, alternative respiration pathway by AOX is also named as cyanide-resistant respiration (CRR). In recent years, the study of the alternative respiration pathway and alternative oxidase has been a hot topic in the area involving cellular respiration metabolism. In this review we summarized the latest research advances about the functions of alternative respiration pathway and alternative oxidase in industrial fungi.
Electron Transport ; Fermentation ; Fungi ; enzymology ; Industrial Microbiology ; Mitochondrial Proteins ; chemistry ; Oxidoreductases ; chemistry ; Plant Proteins ; chemistry

Objective To evaluate the changes of rectal morphology and its clinical value in internal rectal prolapse.Methods The rectal morphology of internal rectal prolapse in thirty-one patients with functional constipation and ten normal control subjects was analysed with defecography.The data were analysed with Mann-Whitney Unonparametric test and Fisher's exact test.Results 23 cases and 2 cases with rectal intussusception in patients group and control group respectively were found.Fisher's exact test was P=0.007.In patients group and control group,the thicknesses of anterior intussusception were(13.51 ±9.42)mm and(3.68±2.34)mm,and posterior intussusception were(5.36±3.92)mm and(2.82±0.99)mm respectively;the intussuscipiens diameters were (37.19±11.79)mm and(25.32±9.25)mm,the intussusceptum lumen diameters were(14.91±4.74)mm and(19.73±6.36)mm,the ratio of intussuscipiens diameters and lumen diameters were 2.82±1.64 and 1.28±0.12,the maximum rectal diameter were(48.97±9.55)mm and(39.84±8.45)mm at rest state.There were significant differences between patients group and control group in above varied values(P＜0.05).Conclusion Defecography can differentiate whole thickness rectal intussusception from rectal mucosal prolapse,which provides the scientific basis for choosing the reasonable treatment.However,caution is required when selecting patients for treatment interventions based on defecography.

Foundations of Oriental Medicine (FOM) is one of the mandatory examinations for the Diplomate of Oriental Medicine (Dipl.OM.), Chinese Herbology (Dipl.CH.), or Acupuncture (Dipl. Ac.) by American National Certification Commission for Acupuncture and Oriental Medicine (NCCAOM). In the light of NCCAOM Certification Handbook, Foundations of Oriental Medicine Expanded Content Outline,and Foundations of Oriental Medicine Study Guide, the authors introduced the examination pattern and examination-related contents including: Clinical diagnostic methods; assessment, analysis, and pattern-differentiation based upon Oriental Medicine theory and treatment principle and strategy.

The scientific communication network for Nobel genetics prize winners was constructed using the biographies of Nobel genetics prize winners in the 20 century as the data source, its structural characteristics were analyzed, the fact that its scale-free distribution and small world phenomena promoted the scientific knowledge exchange between the Nobel genetics prize winner was pointed out, in order to create a beneficial environment for training more out-standing scientists.

Objective To investigate the effect of sustentaculum tali screw placement on outcomes following open reduction and internal fixation (ORIF) of intraarticular calcaneal fractures.Methods A retrospective analysis was made on 139 patients with intraarticular calcaneal fractures treated by ORIF from April 2008 to January 2012.According to Sanders classification,there were 9 patients with type Ⅱ fractures,87 with type Ⅲ fractures and 43 with type Ⅳ fractures.Fracture reduction followed by placement of calcaneal anatomic plate or anatomic locking plate was performed via calcaneal lateral L-shape incision.All the patients received X-rays and CT scans within postoperative 2 weeks.Placement of screws in sustentaculum tail was detected by CT volume rendering to visualize implants combined with multiplanar reconstruction imaging (MPR).Patients were divided into accurate fixation group (Group A,n =28),marginal fixation group (Group B,n =58),and non-fixation group (Group C,n =53) based on radiological results.Intra-and peri-operative parameters,time to partial weight-bearing,time to full weight-bearing,fracture healing time,and clinical outcome were compared among groups.Functional outcome was assessed using American Orthopedic Foot and Ankle Society (AOFAS) Ankle Hindfoot Scale.Results Postoperative X-rays indicated accurate fixation of sustentaculum tail in 64 patients,marginal fixation in 22,and non-fixation in 53,but CT images manifested accurate fixation in 28 patients,marginal fixation in 58,and non-fixation in 53.Group A had operation duration of (93 ±11) min and intraoperative blood loss of (252 ± 27) ml,longer or higher than those in Group B [(85 ±8) min,(194±16) ml] and Group C [(57±6) min,(136 ±13) ml] (P＜O.05).There was no significant difference in mean hospital stay among the three groups (P ＞ 0.05).Ninety-two patients were followed-up for 12-38 months (mean 18.5 months) and 85 patients completed foot and ankle exercise as planned.Moreover,no significant differences were observed among groups concerning time to partial and full weight-bearing,fracture healing time and AOFAS score at the final follow-up (P ＞ 0.05).Conclusion Sustentaculum tali screw placement has no apparent effect on the short-term outcome of surgical treatment for calcaneal fractures.

Objective To observe the changes in excitability of alpha-motoneuron responding to the muscle spindles afferent excitability in the model rats and explore whether the changes in this excitability to be changed as high frequency sinusoidal vibration acted on the soleus muscle.Methods The simulated weightlessness model was created by the tail-suspension.Mechanical vibrations at a frequency of 100 Hz with amplitude of 0.3 mm were acted on soleus muscle.The electromyogram of soleus muscle evoked by electrical stimulation of the sciatic nerve was recorded in control rats and HS rats.Results It was showed that HS and HFV did not influence the tendency of changes in amplitude of H reflex when the stimulation intensity increased.However,after 14-day HS,mean maximal motor response(Mmax)and mean maximal monosynaptic reflex/Mmax(Hmax/Mmax)both significantly decreased,respectively(P0.05).Conclusion It is suggested that HS should lead to the decrease in motoneurons excitability which is resulted from the reduction of muscle spindle afferent.HFV acted on soleus muscle of rats can improve the excitability of alpha-motoneurons in spinal cord during hindlimb suspension.