Australia is a country with strict drug administration, which is hard for its market access. Chinese Medicine Registration Act 2000 enacted by Victoria State of Australia established the legal status of traditional Chinese medicine in Victoria State, which made Australia the first one of western nations to legislate traditional Chinese medicine. We should take advantage of this opportunity to give in-depth analysis of laws and regulations on traditional Chinese medicine in Australia to push on traditional Chinese medicine to enter the Australia market. By analyzing the regulations of traditional Chinese medicine in Australia market, we put forward the following strategies on traditional Chinese medicine accessing Australia market: first, we should strengthen cooperation of Chinese and Australian governments; secondly, we should focus on analysis of regulations of drugs of Australia, thirdly, we should establish technical standard of herbal drugs in conformity with international standard; finally, we should strengthen traditional Chinese medicine culture exchange.

We analyzed and sorted the policies and regulations of traditional medical management in international markets which also affecting traditional Chinese medicine and summaried current situation of barriers of policy and regulation of Ttraditional Chinese medicine.After thoroughly analyzing the reasons of barriers of policy and regulation of traditional Chinese medicine,we found that the reasons lied in culture difference between China and western countries,quality of traditional Chinese medicine,low level of R&D and manufacturing,incomplete domestic laws and regulations of traditional Chinese medicine,lack of anti-technical barriers to trade service system.In the end of this paper,we came up with some countermeasures of barriers of policy and regulation when traditional Chinese medicine accessing international markets.

Traditional Chinese medicine is the few field of owing independent intellectual property in China, the implement of intellectual property strategy is important for the long-term development of traditional Chinese medicine enterprises. At present, traditional Chinese medicine enterprises still remain many problems in intellectual property protection, such as weak awareness of intellectual property protection, lack of intellectual property protection professional personnel, inadequate investment in R & D and low innovation level. These problems caused huge losses in practice to traditional Chinese medicine enterprises. After analyzing the status of intellectual property protection of traditional Chinese medicine enterprises, we put up with some concrete measures of intellectual property protection of traditional Chinese medicine considering the reality of these enterprises.

AMP-Activated Protein Kinases ; genetics ; Heart Diseases ; Humans ; Syndrome

Experimental results showed Zn(Ⅱ)-ammonium thiocyanate-hexadocyltrimethylammonium bromide complex was floated in the presence of sodium chloride. There fore Zn(Ⅱ) could be completely separated from Fe(Ⅲ), Co(Ⅱ),Ni(Ⅱ), Mn(ⅡD, Al(Ⅲ) by floation. The method is non-toxic, simple, rapid and economical.

Objective To explore the effect of high-fat diet on IRS-1 and IRS-2 expressions of fatty liver in rat. Methods After the rats were fed a high-fat diet (n=7) and a standard chow(n=7) for 8 weeks, insulin sensitivity,lipid metabolism, TNF-α and hepatic mRNA and protein expressions of IRS-1 and IRS-2 were measured. Results Compared with the normal control, the high-fat diet group displayed the elevated levels of insulin resistance,FFA and TNF-α.Hepatic IRS-1 mRNA expression and IRS-1 protein content were reduced by 28% and 32%(P<0.01),respectively. Similarly, hepatic IRS-2 mRNA and IRS-2 protein content were also reduced by 30% and 27% (P<0.01), respectively. Conclusions High-fat diet results in a significant decrease in expressions of mRNA and protein of hepatic IRS-1 and IRS-2 in rats, which might be one of the molecular mechanisms of insulin resistance in liver steatosis induced by high-fat diet

Objective To investigate the efficacy and side effects of new combination of high-dose methotrexate (MTX),cisplatin (DDP),pirarubicin (THP),and ifosfamide (IFO) in the treatment of extremity osteosarcoma patients.Methods A retrospective analysis was conducted for 125 osteosarcoma patients treated with the optimized neo-adjuvant chemotherapy combined with the four drugs mentioned above (MTX 200 mg/kg iv 6 h d1,CF 9 mg at one time,12 times; DDP 100 mg/m2,THP 30 mg iv,d8-10;IFO 3.0 g/m2 iv d16-18,mesna after IFO for 0,3,6,9 h).The efficacy and side effects of the therapeutic scheme were evaluated.Results The effective salvage rates of Ⅱ a and Ⅱb schemes were 36.4％ (8/22) and 79.6％ (82/103) with a statistical significance (P ＜ 0.05).The 2-year survival rate of schemes was 62.4％,and the survival time was(17.7 ± 8.3)months.The main side effects were myelo-suppression,nausea,and vomiting,etc.The incidence rate of myelo-suppression,nausea,and vomiting with grade Ⅲ-Ⅳ accounted for 71.2％,37.6％,and 13.6％,respectively.Conclusions The optimized neo-adjuvant therapy strategy based on high-dose MTX,DDP,THP,and IFO is effective in the treatment of osteosarcoma.

This article analyses the pre-management methods and measures for the youth science fund projects granted by the National Natural Science Foundation of China.Systematic procedures include mobilization,preliminary research preparation,professional training and counseling,modifying the application,form and content examination,which can improve efficiency of the National Natural Science Foundation of China youth science project management.

Objective To investigate mechanism and clinical effect of implantation of pacemaker with artial fibrillation(Af) preventive pacing algorithms (Vitatron 900E).Method 24 cases of patients with paroxysmal Af were observed in three phases (each phase two weeks):⑴Monitoring phase,in which onset mechanism of atrial arrtythmias was recorded, the device was programmed into DDD mode with 60 bpm;⑵Lower rate limit phase (LRL),DDDR mode with 85bpm LRL, and evaluating anti-Af effect by elevated rate;⑶Preventive pacing therapy phase,all preventive pacing therapies with programming to on or off, and this phase determined whether combined pacing therapies impacted on incidence of Af. Results 24 cases of patients were free of Af, in which 17 cases were done by using post-PAC-response or/and post-exercise-rate-control therapy only, and 7 cases of 17 casees were done by combining it with cordarone 0 1～0 2g/d also. The other 7 cases were done by DDDR 85 bpm only.Conclusions Af prevention pacing may be benefit for patients with paroxysmal Af,especially with complicated symptomatic bradycardia.

In this study levels of copper-zinc suproxide dismutase (SOD-1) in HL-60 cells and mononucleocytes (MNC) of patients with leukemia were determined by radioimmunoassay and were correlated to DNA content and percentage of S phase of leukemic cells. The results showed that the levels of SOD-1 in HL-60 cells and MNC of AML, CML and B-ALL were higher than those in normal MNC (P