1.The value of corticotropin-releasing hormone and fetal fibronectin in predicting premature delivery
Bei LIU ; Li ZHANG ; Junzhen SHI ; Lin LI ; Mei QU
Clinical Medicine of China 2012;28(1):103-105
ObjectiveTo study the value of plasma corticotropin-releasing hormone (CRH) and the fetal fibronectin (fFN) in vaginal secretions and cervical length in predicting preterm labor.MethodsThe plasma CRH levels and fFN levels in vaginal secretions from 24 -37 weeks pregnant woman checked up in our hospital from Dec.2009 to Dec.2010 were detected by ELLISA method.The changes of these three indexes were observed with the pregnant time and were analyzed according to different pregnancy outcomes.Results Among the 112 cases of pregnant women,premature delivery in 54 cases,full-term birth 58 cases.At the 24 week of pregnancy,there were significant difference on the cervical length( [2.8 ±0.4]cm vs [3.3 ±0.5]cm,t =3.254,P =0.021 ) between premature delivery group and full-term birth group.At the 28 - 30 week,31 -32 week,33 - 34 week,35 - 36 week,the CRH were ( 162.33 ± 16.49 ) ng/L,(60.01:±: 14.56) ng/L;(352.12 ±61.01 )ng/L,( 118.04 ±53.74)ng/L; (364.55 ±56.71 )ng/L,( 122.95 ±71.41 )ng/L; (372.78 ±149.89)ng/L,(124.00 ± 19.05 )ng/L respectively in premature delivery group and full-term birth group,and there were significant differences on CRH at the four different pregnant time(t =3.687,6.875,8.652,8.524,respectively,P < 0.05 ).It shows better sensitivity ( 97.92% ),specificity ( 90.00% ),positive predictive value(95.92% ) and negative predictive value(94.73% ) in predicting premature delivery by detection of CRH,fFN combined with cervical length.ConclusionDetection of plasma CRH,fFN combined with cervix length measurement can improve the predictability of premature and provide a good,reliable clinical basis for the early diagnosis and treatment for preterm premature.
2.Renal medullary carcinoma in child: report of a case.
Li CAI ; Gui-mei QU ; Hou-cai LIU
Chinese Journal of Pathology 2009;38(7):486-487
Anion Exchange Protein 1, Erythrocyte
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metabolism
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Biomarkers
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metabolism
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Carcinoembryonic Antigen
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metabolism
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Carcinoma, Medullary
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metabolism
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pathology
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surgery
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Carcinoma, Transitional Cell
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metabolism
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pathology
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Child
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Diagnosis, Differential
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Female
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Humans
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Keratins
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metabolism
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Kidney Neoplasms
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metabolism
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pathology
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surgery
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Kidney Tubules, Collecting
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pathology
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Mucin-1
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metabolism
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Nephrectomy
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Rhabdoid Tumor
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metabolism
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pathology
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Vimentin
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metabolism
3.Effects of passive smoking on vascular endothelial function in office women
Liang YU ; Mei WANG ; Li GAO ; Wendong QU ; Lun LIU
Chinese Journal of General Practitioners 2008;7(7):453-455
Objective To explore the effects of passive smoking on vascular endothelial function in office women.Methods Totally,94 healthy office women volunteers from urban(36 women)and townships or towns(58 women)were divided into three groups based on the extent of their daily exposure to passive smoking,group A exposed to one to eight cigarettes,group B exposed to nine to 15 cigarettes,and group C exposed to more than 15 cigarettes,respectively,with 20 healthy young women without exposure to passive smoking as controls.Internal diameter of the brachial artery Was measured by color Doppler ultrasound scanning for each of the participants and its changes were observed before and after congestive reaction of the brachial artery test and nitroglycerin test.Results Thirteen of 36 office women from urban and 38 of 58 from townships or towns exposed to passive smoking of more than eight cigarettes daily,with chi-square of 7.74,P=0.0054.The brachial artery in groups A,B and C dilated less than that in the controls did.The brachial artery in group C dilated less than that in the groups A and B did.Conclusion Passive smoking could damage vascular endothelial dilatation function in office women.
4.Nursing care of patients with nasal packing silicone ventilation tube after functional endoscopic sinus surgery
Jie HAN ; Rongkun QU ; Mei HAN ; Min LI
Chinese Journal of Nursing 2009;44(8):724-725
This paper introduces the nursing care of 1556 patients with nasal packing silicone ventilation tube after func-tional endoscopic sinus surgery. Meticulous nursing care during nasal packing silicone ventilation tube could alleviate patients' discomfort obviously. It was emphasized to suck at exact time according to the patients' demands, adopt effective suction means to alleviate the damage of nasal mucosa,such as suction in the tube or in the bottom of the tube, take measures to promote the cleaning of secretion,which could improve the breath and sleep,as well as shorten the time of recovery.
5.Effect of oxymatrine treatment on the invasion of human cervical cancer cells
Qing GAO ; Mei GAO ; Ping QU ; Qipei LI ; Qian CHEN
Journal of Xi'an Jiaotong University(Medical Sciences) 2016;37(3):447-450,459
Objective To investigate the anticancer effect of oxymatrine on cervical cancer cell line (HeLa). Methods MTT assay was used to detect the anti-proliferative effect of oxymatrine.Transwell chamber was used to detect the anti-metastatic effect of oxymatrine.Real-time PCR was used to detect the mRNA levels of MMP-2 and MMP-9.Western blot was used to detect the protein levels of MMP-2,MMP-9,AKT,p-AKT and GADPH. Results We found that application of oxymatrine significantly inhibited the growth of HeLa cells at the concentration above 0.8 mg/mL.We also found that oxymatrine (0.1,0.2 and 0.4 mg/mL)inhibited the invasion of HeLa cells under cytotoxic dose,which was (77.07±20.43)%,(53.95±18.17)% and (20.35±11.20)% of cells that migrated through the matrigel when compared with those of non-oxymatrine treatment group (P<0 .0 5 ). Further research found that oxymatrine (0.1,0.2 and 0.4 mg/mL)could reduce the expression of MMP-2 at the mRNA level,i.e.(82.76±8.71)%,(39.51±12.79)% and (21.53±5.38)% of the expression level when compared with that of non-oxymatrine treatment group (P<0 .0 5 ).The protein expression level of MMP-2 in 0 .4 mg/mL group was (64.69 ±16.52)% of non-oxymatrine treatment group (P<0.05).The phosphorylation level of AKT in 0.4 mg/mL group was (41.27±7.13)% of non-oxymatrine treatment group (P<0.05).Conclusion Oxymatrine can inhibit the invasion of HeLa cells by reducing the expression of MMP-2 via inhibiting the activity of AKT signal pathway.All together,our findings bring new insights into the mechanism of the anticancer effects induced by oxymatrine treatment.
7.Primary small cell carcinoma of the breast: report of a case.
Li-mei QU ; Gang ZHAO ; Ya-bin ZOU ; Yu-E SONG ; Li-rong BI
Chinese Journal of Pathology 2011;40(2):120-121
Aged
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Breast Neoplasms
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metabolism
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pathology
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surgery
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Cadherins
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metabolism
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Carcinoma, Merkel Cell
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metabolism
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pathology
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Carcinoma, Small Cell
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Female
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Humans
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Lymphoma
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metabolism
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pathology
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Melanoma
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metabolism
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pathology
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Phosphopyruvate Hydratase
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metabolism
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Synaptophysin
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metabolism
8.Significance of Basic Concept in Emergency Medicine Teaching
Hong-Wei LU ; Hong-Mei LIU ; Li-Feng DU ; Zheng-An YANG ; Li QU ;
Chinese Journal of Medical Education Research 2006;0(07):-
This article introduced the features and categories of emergency medicine.Combining the comprehension of teaching practices for many years,we considered that paying great attention to basic concepts is the primary problem in emergency medicine teaching.
10.Relationship between methylation status in promoter region of Runx3 gene and children malignant lymphoma
Fan QU ; Jianhui MENG ; Mingjuan YANG ; Yuqiao DIAO ; Xiuli ZHU ; Mei LI
Journal of Leukemia & Lymphoma 2012;21(8):465-467
Objective To study methylation status of the Runx3 gene in occurrence and development of children malignant lymphoma.Methods The bone marrow specimens of 48 children diagnosed as malignant lymphoma were included into experimental group.20 children with non-malignancy were included into control group.Methylation-specific polymerase chain reaction (MS-PCR) was used to detect methylation status of Runx3 gene in bone marrow cells.The reverse transcription-polymerase chain reaction (RT-PCR) was used to detect mRNA expression of Runx3 gene.Results MS-PCR assay results showed that 31 cases expressed Runx3 gene methylation in experimental group,the positive rate was 64.6 % (31/48),but no one was detected in control group (20 cases),the difference between two groups was significant (x2 =15.7,P <0.05).Dynamic observation of 42 cases in experimental group showed the declining of Runx3 methylation positive rate.RT-PCR assay results showed that all 20 cases in the control group expressed Runx3 gene mRNA,all cases with methylation status of the Runx3 gene in the experimental group didn’ t expressed Runx3 gene mRNA.In experimental group,9 cases of clinical remission expressed Runx3 gene mRNA,and 1 case of relapsed didn’ t expressed Runx3 gene mRNA.Conclusion Runx3 gene shows a high methylation status in bone marrow cells of malignant lymphoma children,so that blocked the expression of Runx3 gene,which is closely related to the occurrence and development of children malignant lymphoma.