1.Reference change values and quality standards for thyroid function assay
Xiaoling LI ; Mei ZHANG ; Hengjian HUANG
International Journal of Laboratory Medicine 2015;(4):506-507
Objective To evaluate the reference change values (RCV),individual indexes of TSH,T4,T3,FT3,and FT4 and the limitations of population-based reference ranges.Furthermore,to determine the quality standards based on the biological varia-tion.Methods Acorrding to intra-and inter-individual biological variations,and analytical variations ,RCV and individual indexes of TSH,T4,T3,free T3,and free T4 were calculated,and analytical variations of quality standards based on biological variation were induced.Results RCV of TSH,T4,T3,FT3,and FT4 is 54.0%,16.8%,26.8%,42.8%,23.8%,respectively.Individ-uality index is 0.78,0.45,0.49,0.47,0.45,respectively,and satisfied analytical variation based on biological variation is less than 9.6%,2.5%,4.4%,2.9%,4.0%,respectively.Conclusion When monitoring thyroid functions,the RCV values should be considered.It is important to recognize population-based reference ranges limitations for use in individuals.Quality standards based on biological variation should be meeted when laboratory analysis of variance is determined.
3.Long Term Toxicity of Ginkgolide B Injection on Beagle Dogs
Xiaowu HUANG ; Shichang MEI ; Wai LI
China Pharmacy 2007;0(30):-
OBJECTIVE:To evaluate the long-term toxicity of Ginkgolide B injection on Beagle dogs,and to provide safety evidences for clinical experiment.METHODS: A total of 24 Beagle dogs were equally assigned to receive placebo(control group,n=6) or Ginkgolide B injection at high,medium,and low doses(80,20,and 5 mg?kg-1) by iv gtt for 6 consecutive days per week for up to 90 days.There were 6 Beagle dogs(male: female =1∶1) in each group.All the laboratory indicators were monitored and the recovery of the Beagle dogs was observed.RESULTS: During medication,vomiting was noted in one dog in high dose group,and the clotting time in high and medium dose groups was prolonged obviously.During the recovery stage,one dog in high dose group was strong positive in urinary protein test.No significant drug-associated toxic reactions were noted judging from Beagle dogs' body weight,appetite,temperature,ECG,hematology,blood biochemical analysis,ophthalmology test,marrow test,urine routine test,histopathologic examination etc.CONCLUSION: The non-toxic dose of Ginkgolide B injection for Beagle dogs was 20 mg?kg-1.
4.Using the Antibiotics Rationally in the Treatment of the CNS Infections
Huaijun HUANG ; Bin MEI ; Huagang LI
Herald of Medicine 2001;(2):93-94
Objective:To discuss about the reasonable use of antibiotics for infection of the CNS.Method:The classification and selection as well as the combinative use of antibiotics were reviewed individually. The role of blood-brain barrier,the use of drugs through myelin and their indications were also discussed.Results:Infections of the CNS have been controlled effectively through the use of antibiotic.Conclusion:Rationally using antibiotics in the treatment of infections of the CNS can relieve the economic burden of the patients.
5.Clinical Observation on External Application and Enema of Herbal Medicine Combined with Acupuncture for Adhesive Intestinal Obstruction
Huidong LI ; Yangchun HONG ; Mei HUANG
Journal of Guangzhou University of Traditional Chinese Medicine 2000;0(04):-
0.05).Pain-disappearing time,anus-bubbling time,and time for gas-fluid plane disappearing were shortened in group C,and drainage volume from nutrient canal during gastrointestinal decompression obviously reduced on the second day as compared with those in groups A and B(P
6.Loss of heterozigosity of nm23-H_1 gene might induce lymph node metastasis in no-small-cell lung cancer
Tonghua MEI ; Changyi LI ; Ailon HUANG
Journal of Third Military Medical University 2002;0(12):-
Objective To explore the relationship between the loss of the heterozygosity of nm23-H_1 and the lymph node metastasis in no-small-cell lung cancer (NSCLC). Methods The loss of the heterozygosity of nm23-H_1 gene of cancer tissue and peri-cancerous tissue was detected in 39 patients with NSCLC by Southern blotting. Results The heterozygosity gene of nm23-H_1 is 7.6 kb and 2.3 kb. The LOH rate of the patients with lymph node metastasis (48%, 12/25) was higher than those without lymph node involvement (8%, 1/11) (P
7.Effect of Xiongshang RecipeⅠon Tumor Necrosis Factor and Interleukin-8 in Patients with Acute Pulmonary Contusion
Huidong LI ; Yangchun HONG ; Mei HUANG
Journal of Guangzhou University of Traditional Chinese Medicine 2000;0(04):-
Objective To investigate the effect of Xiongshang RecipeⅠ(XPI)on serum inflammatory cytokines of tumor necrosis factor (TNF)and interleukin-8(IL-8)in acute pulmonary contusion patients.Methods Thirty acute pulmonary contusion patients were equally randomized into the control group (receiving routine western medical treatment)and the treatment group (received routine western medical treatment and oral use of XPI).The treatment lasted 2 weeks.Thirty healthy physical examinees served as the contemporaneous normal controls.Secondary pulmonary contusion,recovery time and the serum levels of TNF and IL-8 were observed after pulmonary contusion.Results Serum levels of TNF and IL-8 in the treatment group after treatment were decreased(P
10.Comparison on intravenous effect between injection with micropump and injection with syringe.
Xia-Li HUANG ; Shi-Hou CHEN ; Yong-Mei ZHU
Chinese Journal of Applied Physiology 2007;23(3):313-354
Animals
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Endothelium, Vascular
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injuries
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Female
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Hemodynamics
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Infusions, Intravenous
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methods
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Injections
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methods
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Male
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Rabbits
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Syringes