Objective To observe the effect of doxepin hydrochloride on refractory hiccups after stroke.Methods 60 patients with refractory hiccup of post-stroke were randomly divided into 2 groups, treatment group :30 cases were given doxepin tablets 25～50 mg orally,3 times a day for 2～8 days;the control group :30 patients were orally adaine stened alprazolam 0. 4mg,3 times a day for 2～8 days. Results The total effective rate was 96. 67% in the treatment group,the total effective rate was 56. 67% in the control group,the effect of the treatment group is better than the control group( P＜0. 05 ). Conclusion The effect of doxepin hydrochloride on refractory hiccups after stroke is obvious,the method is simple,takes effect quickly,no significant side effects,the price is low.

Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is widely expressed in eukaryotic cells and a key regulator of the cell mitosis.During different stages of mitosis,the locations of Plk1 in cells are different,and can interaction with different substrates,thus it has many biological functions.This article focuses on the functions of Plk1 in different mitotic stages.

BACKGROUND:Reinfusion of autologous drainage blood could reduce al ogeneic blood demand after total hip replacement. The application of anticoagulant could ensure the safety of peri-operation period after total hip replacement. ＜br> OBJECTIVE:To investigate the application effect of reinfusion of autologous drainage blood after total hip replacement in patients taking anticoagulant. ＜br> METHODS:100 patients underwent initial unilateral total hip replacement in the Weifang People’s Hospital in China from January 2012 to January 2014. According to reinfusion of autologous drainage blood, the patients were divided into observation group and control group (n=50). ＜br> RESULTS AND CONCLUSION:After replacement, total blood volume and the maximum mid-thigh circumference change were significantly larger in the observation group than in the control group (P＜0.05). No significant difference in hidden blood loss was detected between the two groups (P>0.05). Results indicated that under the application of anticoagulant, reinfusion of autologous drainage blood in patients undergoing total hip replacement does not affect hidden blood loss, but can cause an increase in limb swel ing.

Expression of the T-type Ca2 + channels has been reported in numerous types of tumors due to their unique activation/inactivation properties. In some cancer cells, the expression of T-type Ca2+ channels is proliferation state dependent. T-type channel blockers or interfering the α1 subunit of this channel via siRNA decrease proliferation of these cells. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2 + channel blockers maybe serve as a potential therapeutic approach in the treatment of certain types of cancers.

Objective Analyzed 32 cases of gastrointestinal stromal tumors(GIST) patients,to analysis the clinical and pathological characteristics of gastrointestinal stromal tumors of the stomach and explore associated prognostic factors.Methods Thirty-two GIST patients confirmed pathologically were included from May,2007 to April,2013.Their clinical records were retrospectively analyzed.Results Of the 32 GIST patients,the overall survival (OS) is 85.3％ for the second year.The progression free survival (PFS) is 79.2％ for the second year,respectively.Univariate survival analysis showed that OS and PFS have significant association with tumor size,metastasis,mitotic index and NIH risk group.Conclusions Metastasis and NIH risk group both are potential prognostic factor for gastric GIST.

Objective To observe the clinical effect of orally montelukast combined with doxofylline in older bronchial asthma.Methods A total of 87 stationary phase older bronchial asthma patients were divided into trial group (44 cases) and control group (43 cases).Trial group was given orally montelukast 10 mg 1 time/d,doxofylline 0.2 g,2 times/d.Control group was given inhaled fluticasone 250 μ g,2 times/d,a total of 3 months.The forced expiratory volume in one second (FEV1),peak expiratory flow rate (PEFR),one second rate (FEV1/FVC),asthma control test (ACT) score and the adverse reaction were compared between the 2 groups.Results There were no significant differences in FEV1,PEFR,FEV1/FVC before treatment between the 2 groups (P ＞ 0.05),they were significantly improved after treatment [trial group:(2.20 ± 3.21)L vs.(1.68 ± 0.71) L,(3.97 ± 0.32) L/s vs.(3.27 ± 0.32) L/s,(76.18 ± 1.02)％ vs.(63.91 ± 1.40)％,control group:(2.24 ±0.75) L vs.(1.71 ± 1.58) L,(4.06 ±0.34) L/s vs.(3.29 ±0.28) L/s,(77.85 ±0.67)％ vs.(62.37 ± 1.29)％],there were statistical differences (P ＜ 0.05).But there were no statistical differences after treatment between the 2 groups (P＞ 0.05).According ACT score,total effective rate in trial group was 90.9％ (40/44),in control group was 95.3％(41/43),there was no statistical difference (P ＞ 0.05).The rates of adverse reaction in trial group and control group were 4.5％(2/44) and 7.0％(3/43),there was no statistical difference (P ＞ 0.05).Conclusions The curative effect of orally montelukast combined with doxofylline in older bronchial asthma closes to the classic solution of inhalation fluticasone,which is easily accepted by older patients,and safety.It provides another option for older bronchial asthma patients.

Diabetic macular edema (DME) is a common complication of diabetes that can lead to severely impaired visual acuity.Its pathogenesis is complex,which is closely related to the destruction of blood-retinal barrier,and there are many cytokines involved in its formation,but the exact mechanism is not yet fully clear.Recent researches suggested that some typical pathological characterizations of retina can be used as criteria for evaluating its occurrence,and it is known that a variety of risk factors participated in the pathological process,such as glucose,blood pressure,blood lipids,which are well-known and can be closely correlated with its development through impacting the systemic and retinal vascular functions by complex mechanisms and leading to endothelial dysfunction.While other systemic risk factors,such as diabetic nephropathy which leads to changes in osmotic balance,anemia which increases cytokines caused by ischemia and hypoxia,excessive body weight which leads to vascular damage through fat factor,smoking that produces blood vessel damage by promoting oxidative stress on the body and various hypoglycemic drugs,will influence the development of macular edema on different levels.So conducting a comprehensive and newest understanding of this disease and its risk factors are conducive to better prevention efforts for diabetes patients.This review mainly summarizes the latest researches on definition,classification,pathologic characterization and risk factors of DME.

To study the effect of postural change on intraocular pressure ( lOP ) fluctuation in open angle glaucoma patients after trabeculectomy, and to discuss the value of this investigation on prognosis.METHODS:Fifty-one cases (62 eyes) of primary open angle glaucoma were selected as the research object. Perkins ophthalmotonometer was used to test lOP at the time when patient seat ( first seat ) . The patients were asked to lie supine for 25min, detected lOP, and the patients seated again (final seat), sustaining for 15min, detected lOP. According to whether the lOP range was more than 5mmHg, they were divided into high volatility fluctuation group and low volatility fluctuation group. We recorded their visual field progression ( with AGlS score) , HPA staging, in order to evaluate the correlation of lOP range with them. Reviews were made 3mo a time, and lasted for 1a, in order to evaluate the relation between lOP range and AGlS scores.RESULTS: The lOP of first seat was 18. 1+2. 2mmHg. There was no significant difference in the same position (P>0. 05 ). The lOP range was 4. 1 ± 1. 5mmHg. Low volatility fluctuation group was more likely to have low AGlS score and to be early vision HPA ( P<0. 001, P<0. 05 ) . There were significantly positive correlation between lOP range and AGlS (r=0. 412, P<0. 001); With time increasing, the number of patients whose visual field progression was increased, and the lOP was also raised. At any time the two were positively correlated (P<0. 01).CONCLUSlON:Visual field progression is related to the degree of lOP fluctuation in open angle glaucoma patients after trabeculectomy, so we can predict the prognosis of patients simply by detect lOP fluctuation. This is good to adjust the lOP control scheme.

With the development of transportation and construction, due to the increasing incidence of spinal cord injury, patients mainly rely on family caregivers.The paper reviewed the type of care burden and the influencing factors, and nursing intervention mode to decrease the caregivers' burden of spinal cord injury patients. We wish to provide suggestions for building nursing intervention model of Chinese spinal cord injury caregivers .

[Objective]The article summarizes the essentials of clinical dialectical experience by professor Ye Bai,the famous TCM physician. [Medthods] From following professor Ye Bai clinical studies and his expository teaching,summarize the experience and thoughts of treat peptic ulcer,and for a case. [Results]Ye Bai deems of the main reason for the occurrence of PU is the deficiency cold of spleen and stomach, liver-stomach disharmony, and puts forward that we should pay attention to replenishing spleen,regulate qi precautions injurying yin,don't forget to activate blood in the long illness when we treat it, and emphasizes the combination of disease differentiation and syndrome differentiation, to improve the prognosis, reduce the adverse reactions and recurrence rate of treatment principle. [Conclusion]Ye Bai has adepted in treating the PU that has a perfect effect,the experience covers ancient and new ways, worth popularzing and studing.