Objective To explore the influence of case management on short-term intensive insulin therapy effect,including treatment compliance,safety and glucose metabolic index in newly diagnosed type 2 diabetic patients in outpatient clinic. Methods A total of 100 newly diagnosed type 2 diabetic patients in outpatient clinic were enrolled in this study and randomly divided into 2 groups:intervention group (n=52)and control group (Con,n = 48 ). The intervention group received standard insulin injection case management provided by a team composed of doctors and nurse case manager. The control group received routine insulin injection education in outpatient. Attitudes and compliance of insulin treatment,incidence of hypoglycemia,fasting blood glucose (FBG) and glycated haemoglobin A1c (HbA1 c ) were compared between the two groups at baseline and after 3 months follow up. Results After intervention,the total score and scores by dimension of insulin treatment attitude were higher in intervention group than in Con group[(76.30 ± 4.06 )vs (60.53 ± 3.18 )score,P < 0.01 ]. Insulin treatment compliance was better in intervention group than in Con group (82.7％ vs 64.6％,P < 0.05 ). The hypoglycemia incidence was lower in intervention group than in Con group (19.2％ vs 31.3％,P >0.05),although without statistical difference. FBG and HbA1 c were all lower in intervention group than in Con group [(6.79 ± 1.41 )vs (7.51±1.15)mmol/L,(6.62±0.69)％ vs (7.15±0.75)％,P <0.05]. Conclusion Case management could effectively improve the insulin treatment attitude and compliance,and then optimize glycemic control innewly diagnosed type 2 diabetic patients treated with short-term intensive insulin therapy in outpatient clinic.

Objective:To observe the effect of storage period of three experimental dentin self-etching primers on the shear bond strength.Methods:Three experimental primers with 2-hydroxyethyl methacrylate (HEMA)or N-methacryloyl glycine (NMGly)as a hydrophilic monomer and 1 0-methacryloxydecyl dihydrogen phosphate(MDP)or N-methacryloyl-2-aminoethylphosphonic acid (NMEP) as an acid monomer,were designed.Immediately after preparation of the samples of MDP-HEMA,MDP-NMGly and NMEP-NMGly, the primers were stored at 40 ℃for 0,6 and 1 4 weeks.At the end of each storage period,the shear bond strength of resin to dentin(n=1 4)and the pH value of the primers were measured.Results:After storage at 40 ℃ for 1 4 weeks,the shear bond strength of MDP-HEMA decreased from (1 7.61 ±1 .56)MPa to (7.53 ±1 .76)MPa;however the bond strenth of MDP-NMGly and NMEP-NMGly did not decrease;most of the specimens of MDP-HEMA and MDP-NMGly exhibited an interfacial failure of the resin from the dentin sur-face;however NMEP-NMGly exhibited a cohesional failure of the dentin and/or resin.The SEMimages showed a separation of resin and dentin of MDP-HEMA and MDP-NMGly had storaged at 40 ℃for 1 4 weeks;while the interface of NMEP-NMGly did not change.Con-clusion:The NMEP-NMGly primer has noticeably higher hydrolytic stability than the MDP-HEMA and MDP-NMGly primers.

Eisenmenger syndrome (ES) was considered as a surgical contraindication in the past time. Only a few patients got lung transplantations or heart-lung transplantations due to lack of donors. Most of the patients had to choose conservative treatment to prolong their survival time. Recently, some clinical trials indicated targeted therapies in pulmonary arterial hypertension (PAH) were effective for the treatment of ES. This article reviewed the recent advances in this area.

Objective To set up care service quality evaluation indicators and establish weight coefficient for assessment of elderly institution in Chongqing.Methods SEVQUAL Model was used as the theoretical guidance,through Delphi expert inquiry,analytic hierarchy process (AHP),the weight of each indicator in five grades and consistency check was calculated.Results The care serv ice quality evaluation indicators contained five first-grade indexes and twenty second-grade indexes.The first-grade indexes included tangibles,reliability,responsiveness,assurance,empathy,respectively.The results of the consisten-cy check of the single grade sorts had a satisfying consistency(CR＜0.10).Conclusions The scientific meth-ods and comprehensive indicators were applied to the construction of care service quality e-valuation indicators for elderly institution in Chongqing.In some degree,this construction of indicators may improve quality of care service and provide useful reference evidence for quality assessment in elderly in-stitution.

Colorectal cancer(CRC) is kind of the common malignant tumor worldwide.Bad prognosis is always due to distal metastasis.In recent years,the research on chemokines targeted on cancer metastasis and directing on the movement of the tumor cells have been more and more deeply taken into consideration.Chemokine CXCL12 and its specific chemokine receptor CXCR4 play important roles in CRC cell's targeted cancer metastasis and directing movement by signal transduction mechanism.Researches showed that it can inhibit the migration and invasion of the tumor through interception chemokine receptor CXCR4 by many ways.The studies of this signal may be a potential target sit for gene therapy.The aim of this review was to summarize the current knowledge of these researches.

Objective To investigate the acaroid mite pollution in houses in Huaibei area,Anhui province and to prevent allergic diseases caused by acaroid mites. Methods The samples of acaroid mites were collected from the houses,hotels and undergraduate dormitories,then the acaroid mites were separated,classed and counted. Results Fifteen kinds of acaroid mites were detected from the samples,belonging to 5 families,11 genera. The analysis showed that average density of acaroid mites in the common houses ranked the first,32.5. The values of the species richness index R was 1.36,the species diversity index was 2.16,the species evenness index was 0.9. Conclution The density of acaroid mites in the common houses is higher in Huaibei area and the effective measure should be taken to control the acaroid mites.

Objective To investigate the correlation between social support and psychological health status of paid blood donors infected with HIV to implement psychological intervention in these people.Methods Sixty individuals responded to questionnaires using self-designed questionnaire,SCL-90 and questionnaires on quantity social support.Results Compared with the national norm,the scores of somatization,obsessive compulsion,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety and psychoticism of the paid blood donors infected with HIV were significantly higher(P

Multiple modality treatment has been adapted for the treatment of various cancers,the outcome has been dramatically improved,but some of unique side effects due to the modalities like chemotherapy combined with radiotherapy have been observed in the clinic. Radiation recall dermatitis(RRD) is one of the side effects. In this paper,the etiology,clinical features,diagnosis,treatment and related factors of the radiation recall dermatitis are discussed.

Magnetic resonance spectroscopy(MRS)is an advanced medical imaging technique that can provide more accurate physiological and biochemical information than an MRI.MRS has more advantages in displaying abnormal physiological signs than the conventional MRI.A key problem in radiation therapy is the definition of the tumor target volume.MRS can define the tumor margin and range as well as predict the immediate response or side effects to radiotherapy.This paper summarized the role of MRS in tumor volume definition and clinical evaluation in radiation therapy.

The antineoplastic drugs pingyangmycin ( PYM ) and adriamycin ( ADM ) and biological response modifier thymosin were tested for the effects on concanavalin A ( Con-A ) induced interleukin-2 ( IL-2 ) production by MTT colorimetric assay. When the drug was added to splenocytes of BALB/c mice in the presence of suboptimal dose of Con-A for 24h ,PYM increased IL-2 release over a wide range of doses, and this effect was achieved when using less than 0.01mg/L PYM. However, 10mg/L PYM inhibited IL-2 activity in the supernatant of cultures. ADM was able to enhance the production of IL-2, and thymosin enhance production of IL-2 too.When PYM or ADM applied with thymosin, the additive effects were shown. The activity of IL-2 was increased significantly.