Child ; Child, Preschool ; Drug Therapy ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; drug therapy ; Remission Induction ; methods ; Survival Analysis ; Treatment Outcome

Objective To study the risk factors and clinical features on acute hepatic dysfunction induced by sepsis.Methods One hundred and sixty-eight patients with sepsis were divided into 2 groups according to liver function:simple sepsis group (control group,142 cases) and acute hepatic dysfunction induced by sepsis group (observation group,26 cases).The biochemical indicators,plasma endothelin (ET)-1,sepsis-related organ failure assessment (SOFA) were compared between 2 groups.The risk factors of inducing acute hepatic dysfunction were analyzed.Results The incidence of acute hepatic dysfunction in 168 patients with sepsis was 15.5％ (26/168).The total bilirubin,direct bilirubin,creatinine,range of blood glucose variation,arterial blood lactic acid,plasma ET-1,SOFA,fatality rate in observation group were significantly higher than those in control group [(35.9 ±9.8) μμmol/L vs.(27.8 ±6.7) μmol/L,(17.7 ± 8.0) μ mol/L vs.(12.3 ± 5.9) μ mol/L,(219.6 ± 156.4) μ mol/L vs.(159.4 ± 125.3) μ mol/L,(7.6 ±4.9) mmol/L vs.(3.0 ± 1.6) mmol/L,(3.8 ± 1.3) mmol/L vs.(2.0 ± 1.2) mmol/L,(79.6 ±25.7)μg/L vs.(60.8 ± 12.6) μg/L,(8.8 ±2.6) scores vs.(5.7 ± 1.8) scores,38.5％ (10/26) vs.17.6％(25/142)],there were statistical differences (P ＜ 0.01 or ＜ 0.05).Multifactor Logistic regression analysis results showed that long-term drinking,cardiac insufficiency and hypotension were independent risk factors of acute hepatic dysfunction induced by sepsis.Conclusions The arterial blood lactic acid,plasma ET-1 and SOFA in patients with acute hepatic dysfunction induced by sepsis are higher.Long-term drinking,cardiac insufficiency and hypotension are the risk factors of acute hepatic dysfunction induced by sepsis.

Pancreatic cancer has a very poor prognosis, with a five-year survival less than 5%. Nowadays, to improve the treat-ment efficacy of pancreatic cancer has been a highlight for medical researchers worldwide. Increasing knowledge about the molecular pathogenesis of the disease has shown that genic mutations, such as oncogene Kras2, and anti-oncogenes Cdkn2a, and TP53, are hall-marks of pancreatic cancer. Therefore, it is vital to deeply understand the pathogenetic mechanism of pancreatic cancer and find new therapeutic strategies to cover it. In this review, we summarized the recent advances in the signaling pathways of pancreatic cancer.

Objective To develop a double-wavelength HPLC method for the simultaneous determination of neogambogic acid,gambogic acid,( +)-catechin and L-epicatechin in Litong pill. Methods The quantitative analysis was carried out on C18 column(250 mm×4.6 mm,5 μm).A linear elution of methanol-acetonitrile(4: 1)and 0.2% phosphoric acid solution was adopted at the flow rate of 1.1 mL·min-1 ,with the detection wavelength set at 360 nm for neogambogic acid and gambogic acid,and at 280 nm for(+)-catechin and L-epicatechin. Results The linear ranges of neogambogic acid,gambogic acid,(+)-catechin and L-epicatechin were 5.85-117.00 μg·mL-1(r= 0.999 5),8.95-179.00 μg·mL-1(r= 0.999 8),6.90-138.00 μg·mL-1(r= 0.999 7),and 5.30-106.00 μg·mL-1(r = 0.999 9),respectively.The average recoveries were 97.82%(RSD= 1.21%),98.72%(RSD = 1.30%),96.96%(RSD = 0.84%)and 99.26%( RSD = 1.46%)for neogambogic acid, gambogic acid,(+)-catechin and L-epicatechin,respectively. Conclusion The method is simple,accurate,reproducible and may be used for the simultaneous determination of neogambogic acid,gambogic acid,(+)-catechin and L-epicatechin in Litong pill.

Objective To investigate the effect of sanbai granules on the patients with leucoderma.Methods 180 cases with leucoderma were selected and divided into two groups.90 cases in the control group were treated by Methoxsalen Tablets 10mg,1 times a day,2h sunlight after the medication,appropriate amount external of Compound Kaliziran tincture and Halometasone.90 cases in the experiment group were treated on the base of the control group with Sanbai granules.The activity of tyrosinase,amount of melanin in the serum,clinical effect and amount of skin regeneration between two groups were compared.Results Compared with the control group, the activity of tyrosinase and melanin in serum of the experiment group were higher (P<0.05),the clinical effect rate were higher(P<0.05),number of skin regeneration piece was higher(P<0.05).Conclusion Sanbai granules can effectively improve the activity of tyrosinase and melanin in patients with leucoderma, and it has important significance for the treatment of leucoderma.

Vitamin D ( VD) has been stated clearly in maintaining the balance of serumcalcium and phosphorus in human . Whereas, more and more evidences show VD has a considerable range of other physiological functions .VD has also been proposed to have vital functions controversially including adjusting immunity, antitumor, enhancing barrier in the intestine .The patients of short bowel syndrome are at particularly high risk of vitamin D deficiency .It has a significance in prevention and treatment of diseases to fur-ther clearly clarify the relationship and mechanisms of VD and the diseases .

Objective To investigate the influence of psychological intervention on the anxiety of patients with obstructive jaundice and supply theoretical reference for psychological evaluation and nutsing.Methods 129 patients with obstructive jaundice was divided into the intervention group(64 cases)and the control group(65 cases).The control group adopted routine treatraent method such as anti-infection,liver protection treatment,enhancement of coagulation mechanism and supporting treatment.The intervention group received psychological nursing,relaxation training and distraction of attention based upon routine nursing.The degree of anxiety and pruritus was obseved and recorded in the two groups.Results The degree of anxiety in the intervention group was evidently lower than that of the control group(P＜0.01).The degree of pruritus in the intervention group was 18.75%,which was statistically different from that of the control group(35.38%),P＜0.05.Condusion Adoption of psychological intervention could effectively reduce the degree of anxiety and pruritus of patients with obstructive jaundice.

Nitrogen pollution in water body can not only cause eutrophication but also has direct hazardous effects on animals and human beings. The removal of ammonium is an important process in modern wastewater treatment systems. It is generally achieved by a traditional treatment system of combination of two processes,aerobic nitrification and anoxic denitrification,but these processes are very complex and the cost is higher. In recent years,some new principles have been proposed,such as aerobic denitrification,anaerobic ammonium oxidation,heterotrophic nitrification,which make simultaneous nitrification-denitrification possible. The domestic and foreign study progress in aerobic denitrification was reviewed in this paper.

Bronchial asthma is defined as a chronic inflammatory airway disease in response to a wide variety of provoking stimuli.Over 200 million people in the world are affected with asthma.Because the incidence of asthma appears to be increasing,the importance of proper perioperative management of persons with asthma will also continue to increase.Patients with asthma are thought to be at high risk for pulmonary complications to develop during the perioperative period,and these complications may lead to serious morbidity.So it is very important to control asthma,to prevent and treat pulmonary complications for increasing operational success rate.

Chemical constituents of the aerial parts of Qianhu were compared with those present in the roots by RP-HPLC. It was found that the constituents in aerial parts of Peucedanum praeruptorum are similar and higher in content than that in the roots. So it is possible that the aerial parts can be used instead of the roots of the plant. But the chemical constituents in the aerial parts and the roots of P. decursivum are quite different, rendering it impossible to use the aerial parts instead of the roots of the plant.