Angioimmunoblastic T-cell lymphoma(AITL) is a subtype of peripheral T-cell lymphoma,clinically characterized with systemic symptoms and aggressive behaviours. To date, the standard approach for treating patients with AITL is still unknown. Combination chemotherapy regimens have failed to significantly improve prognosis and durably maintain the remission. Targeted drugs and immunomodulator agents could not conclude the role because of the small number of patients in these studies. High dose therapy with autologous stem cell transplantation and allogeneic hematologic stem cell transplantation are both comparatively efficient.High dose therapy with autologous stem cell transplantation has many risks, such as higher relapse rate and long-term secondary tumor. Owing to higher transplant related mortality , allogeneic hematologic stem cell transplantation will be further explored. This review presents the status of treatment study in AITL.

Breast Neoplasms ; blood supply ; classification ; genetics ; pathology ; Female ; Genes, BRCA1 ; Genes, MDR ; Genes, erbB-2 ; Humans ; Lymphatic Metastasis ; Mutation ; Neovascularization, Pathologic ; Sentinel Lymph Node Biopsy

Breast Neoplasms ; pathology ; surgery ; Carcinoma, Ductal, Breast ; pathology ; surgery ; Carcinoma, Papillary ; pathology ; surgery ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Mastectomy, Segmental ; Neoplasm Invasiveness

Breast Neoplasms ; diagnosis ; pathology ; Carcinoma ; diagnosis ; pathology ; Female ; Humans ; Male ; Mammography ; methods ; trends ; Neoplasm Invasiveness ; pathology ; Neoplasm Proteins ; analysis

Breast Neoplasms ; chemistry ; diagnosis ; pathology ; Carcinoma, Ductal, Breast ; chemistry ; diagnosis ; pathology ; Carcinoma, Papillary ; chemistry ; diagnosis ; pathology ; Diagnosis, Differential ; Female ; Humans ; Lymphatic Metastasis ; Neoplasm Invasiveness ; Prognosis ; Receptor, ErbB-2 ; analysis ; Receptors, Estrogen ; analysis

Objective To analyze the clinical nusing care methods and effects of patients complicated with tuberculosis during pregnancy or puerperal state.Methods Clinical data of 39 cases of patients complicated with tuberculosis during pregnancy or puerperal state were retrospective analyzed.Results After comprehensive treatment and nursing care,4 cases died,others got good prognosis.Conclusions Meticulous treatment and nursing can promote the rehabilitation of patients complicated with tuberculosis during pregnancy or puerperal state.For these patients,the cure rate can be improved and the recurrence rate can be reduced by choosing suitable treatment and nursing care programs,paying attention to psychological care and health education,ensuring patients taking medicine regularly.

Bone Marrow Cells ; pathology ; Bone Marrow Neoplasms ; pathology ; physiopathology ; Humans ; Neoplasm Metastasis ; pathology ; physiopathology ; Tumor Cells, Cultured

Radiotherapy is one of the main means of local treatment of breast cancer. Triple negative breast cancer (TNBC) as a molecular subtypes of breast cancer, its biological behavior is special and existing multiple molecular targets, these molecular targets inlfuence the response of ionization radiation through different mechanisms and regulate radiotherapy sensitivity of TNBC This article reviewed the recent advances in radiotherapy and radiosensitivity related molecular targets of TNBC.

Studies have shown that most of the sequence in the mammalian genome is transcribed into long noncoding RNAs (lncRNAs). Their crucial roles in gene regulation are becoming a hotspot in current biomedical research. LncRNAs can control gene activities through multiple mechanisms such as: 1) direct or indirect regulation of gene expression via cis-/trans-action or function as protein baits in the nucleus; 2) affecting the stability and the translational process of mRNA; 3) functioning as competitors to regulation of microRNA; 4) binding to transcription factors. Recent studies have highlighted the significance of lncRNAs in development and diseases, and their potentials in future clinical application.

Objective: To evaluate psychometric properties of a Chinese version of Adult Attachment Questionnaire (AAQ3.1). Methods: Score s on the AAQ3.1 were c ompared among 152 students,114 students' parents and 37 patients. Results: In ternal consistency in terms of item-total correlations was found to be high, but somewhat lower than what was found in the West. High discriminative power was f ound for differentiating between clinical and non-clinical samples, as well as b etween adult and adolescent samples. Significant correlation was found between husbands and wives. Conclusion: AAQ3.1 have acceptable re liability and validity for evaluating attachment of Chinese adults.