Objective To explore the reason and the degree of dysphoric mood of family members of children with scoliosis, and then make out some countermeasures to ameliorate these dysphoric mood. Methods Divided 64 family members of children with scoliosis into the observation group and the control group randomly. Using nursing intervention in the observation group and none in the control group. Evaluated the mood of 2 groups by the end of research by using the Zung Self-judged scale and the questionnaire. Results Different causes have induced different degree of dysphoric mood of family members of children with scoliosis. After using the nursing intervention, there were significant difference between the 2 groups in dysphoric mood, P

Objective To survey the faculty doctors in psychiatric specialist training basement of Sichuan Province so as to provide a foundation for improving the faculty's ability and to promote the psychiatric specialist doctors training project.Methods To survey the 90 psychiatric specialist training faculty doctors by giving out a self-made questionnaire.Factor analysis were done by adopting SPSS 13.0.Results There were 90 self-made questionnaires given and 90 received.The effeetual questionnaires were 84.The results showed as follows:the average age of faculty doctors was 38.56±8.04,the average teaching time Was 14.32±8.44,faculty doctors with bachelor degree and more were 80.95%,the ratio of full-time teachers was 5.95%,the ratio of primary titles was 27.40%,the ratio of middle tides was 22.60%,the ratio of vice-senior titles was 33.30%,the ratio of senior titles was 16.70%;the ratio of the faculty doctors who enrolled in system training program was 28.57%,the ratio of the training time less than half year was 71.43%,the ratio of wanted to take part in system training was 95.24%.Conclusion The constitute of the faculty doctors'age.degrees and title were reasonable.But the teachingtime Was short and there were short age of full-time teachers.The time of system training was rather short.The faculty doctors demanded to take part in system training program.

Angiotensin II ; metabolism ; Cisplatin ; adverse effects ; Humans ; Kidney ; drug effects ; Kidney Diseases ; chemically induced ; metabolism

Objective To search for the effect of benidipine,a kind of Ca2+ blocker,on NO and ET-1 of patients with coronary heart disease.Methods Benidipine(2~4 mg/d)were given to the patients with coronary heart disease diagnosed definitely for 8 weeks.Forty healthy candidates were enrolled in the control group,and their morning fasting blood were tested for NO and ET-1 levels at the 4th,8th week in order to compare with the control group.Results Blood NO level of CHD patients was lower and blood ET-1 level was higher than the control group remarkably.After treatment NO level was increased and ET-1 level was decreased separately.Conclusion Benidipine can increase NO level and decrease ET-1 level,which demonstrated the protective effect of benidipine for endothelia.

Objective To investigate the effect of rosiglitazone (ROS),a peroxisome poliferator- activated receptor (PPAR)?ligand,combined with all-trans retinoic acid (ATRA) on anti-angiogenesis of transplanted gastric cancer in nude mice,and to explore the mechanism of anti-angiogenesis prelimina- rily.Methods The model of xenograft tumor in nude mice were established by inoculating human gastric cancer cells line MGC803 (lower differentiated) into the back of nude mice subcutaneously.The cancer- bearing nude mice were divided randomly into 5 groups:group 1 (n=6) with no treatment;ROS treat- ment (group 2,n=6),ROS combined ATRA treatment including:low dose treatment (group 3,n= 6),moderate dose treatment (group 4,n=6) and high dose treatment (group 5,n=6).After treated for forty days,the volume change of tumor and tumor inhibition rates were observed.The expression of CD34,vascular endothelial growth factor (VEGF) in grafts were detected by immunohistochemical and calculated the difference of MVD.The mRNA expression levels of VEGF,HIF-l?were detected by RT- PCR assay accordingly.Results①The volume of tumor was significantly decreased in ROS treatment group compared with group 1 (P＜0.01).The tumor inhibition rates of group 2 were similar to group 3 (P＞0.05).With the increasing of the dose of ROS the tumor inhibition rates were increased.They were dose-dependent in specified dose-range.②ROS could inhibit angiogenesis of xenograft tumor and depress expression of mRNA of VEGF and HIF-l?.When ROS combined with ATRA,the increasing of dose of ROS,inhibiting angiogenesis of tumor and depressing expression of mRNA of VEGF and HIF-l?were found (P＜0.05).Conclusion ROS (25 mg?kg?2 d~(-1)) can inhibit the growth of tumor,and ROS combined with ATRA can further inhibit the growth of tumor,which may be through the path of PTEN by inhibiting the angiogenesis of tumor

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline. The pathological eatures of Alzheimer's disease are abnormal deposition of amyloid beta-peptides (Aβ), neurofibrillary tangles, cholinergic deficits, and loss of synaptic processes and dendritic spines. Senescence accelerated mouse prone 8 exhibits age-related deficits of learning and memory from an early age, tau protein phosphorylation, neurotransmitter changes, synaptic structure and function disorders, circadian rhythm disorders,as well as gene expression and many other characteristic changes, which are consistent with Alzheimer's disease pathological changes，and can be used as an ideal animal model for Alzheimer's disease prevention drugs development.

Annexin A5 ; biosynthesis ; isolation & purification ; Escherichia coli ; metabolism ; Genetic Vectors ; Humans ; Recombinant Proteins ; biosynthesis ; isolation & purification

Protein phosphatase 2A(PP2A)is the main serine/threonine protein phosphatase of the brain,and it is involved in many physiological and pathological processes in the cell. Particularly in the pathogenesis of Alzheimer′s disease(AD),PP2A is closely related to the main pathological features of AD. Deregulation of PP2A enzymes correlates with increased tau phosphorylation, the formation of amyloid precursor protein,and the missing of neurons. PP2A as the target of drug development may bring new hope for the treatment of AD. This review introduces the structure and activity regulation of PP2A,and the role of PP2A in AD.

OBJECTIVE:To investigate the use and trend of lipid modifying agents in 83 Shanghai hospitals during the period 2004～2006.METHODS:Lipid modifying agents used in 83 Shanghai hospitals were analyzed statistically in respect of the kinds,consumption sum and DDDs etc.RESULTS:During the period 2004～2006,the use of lipid modifying agents increased year by year,with mean annual incremental rate of 15.40% in consumption sum and 15.37% in DDDs,but the average daily costs had no significant change.Leading the list in terms of consumption quantity were simvastatin,pravastatin and fenofibrate.CONCLUSION:The development trend of lipid modifying agents is promising.

OBJECTIVE:To provide reference for playing pharmaceutical support role of clinical pharmacist to offer medical assistance in the emergence such as earthquake.METHODS:Basing on the experience in Wenchuan Earthquake,the character and forms of earthquake medical assistance were introduced,then the role of clinical pharmacist in earthquake medical assistance were analyzed.RESULTS:Clinical pharmacists distributed effectively to the drug supply so as to save medical resources and ensure rational administration during the medical rescue in earthquake.CONCLUSIONS:For achieving better function of the treatment team,national medical rescue team should involve clinical pharmacist.