Objective To explore the effect of the H-uvulopalatopharyngology(H-UPPP)on the obstructive sleep apnea hypopnea syndrome(OSAHS)with hypertension sufferers.Methods The clinical data of 100 cases of OSAHS patients with hypertension were analyzed retrospectively,and the related parameters about changes of blood pressure and respiration were analyzed.Results The sargical operation treatment cure rate of OSAHS eas 37%,and the effective rate was 81%.In those patients.all the hypertension patients who in the first stage were completely cured (46/46),while for whom in the second stage,the cure rate was 37%(13/35).So the total effective rate of experimental group Was 88%(30/35).19 cases was ineffective.In those 19 patients,there were 16 patients in the second stage,while 3 cases in the third stage.Conclusion H-UPPP could completely cure OSAHS,meanwhile,it also obviously lowered hypertension which induced by OSAHS,and made the sufferers keep at relative normal blood pressure for a long time.So H-UPPP Was a best treatment method to the OSAHS patients with hypertension.

[Objective]The relationship of inheritance and innovation is one of most important problems of TCM.Wind of historyis a historical theory pro-posed by Liu Xianxin. We use the theory to analyze the inheritance and innovation in the history of TCM, so that we can identify the relationship of inheri-tance and innovation of TCM under current background. [Methods]Based onWind of historytheory, we try to analyze classic innovated case in the history of TCM.After that, we analyze the current relationship and controversy of inheritance and innovation of TCM. [Results]We find that al innovation comes from the interaction of inheritance and the Wind of history. Different innovation comes from the interaction of different problems and different wind. [Conclusions]We need not make innovation as the purpose or requirements imposed on TCM. If we have better inheritance, innovation is just there when we confront new problem.

Objective To study clinical manifestations, diagnosis, treatment, as well as effect of surgical operation, of primary mediastinal large B-cell lymphoma (PMBCL).Methods Data of 19 patients of PMBCL with complete clinical and pathological records hospitalized at Peking Union Medical College Hospital during 1998 to 2008 were retrospectively reviewed and analyzed.Kaplan-Meier method was used to estimate their survival time and survival rate in comparison of efficacy in those with surgical operation to those without it.Results Overall three-year survival rate was 54% for all the 19 patients, 55% for those with surgical operation and 54% without it, respectively, with an average survival time of 44 months, 44 months for those with surgical operation and 42 months without it, respectively, but not reaching at statistical significance.Symptoms of superior vena cava syndrome in five cases at admission relieved immediately after surgical operation, but symptoms of superior vena cava syndrome in three of nine cases in non-surgical group relieved gradually one to three weeks after chemotherapy.Conclusions Surgical operation has no significant effect on survival in patients with PMBCL, but it can relieve syndrome of superior vena cava syndrome and provide accurate pathological diagnosis.

Objective To invetigate the application value of antigen‐antibody joint detection in increasing the detection rate of hepatitis C infection in the patients with hemodialysis .Methods The clinical data of 100 cases of hemodialysis were collected .Hep‐atitis C virus(HCV) core antigen ,HCV antibody and HCV‐RNA were detected by adopting ELISA ,Chemiluminescence and RT‐PCR respectively .The positive expression situation of each detection item in the same specimen was performed statistics .The detec‐tion rates of RNA positive specimen were compared among the single antigen detection ,single antibody detection and joint detection schemes ;at the same time the antigen level of antigen positive specimens ant its RNA copy number were performed the correlation analysis .The antibody levels in the positive antibody specimens were compared between the RNA positive group and the RNA neg‐ative group .Results The single antigen or single antibody detection could cause the missed detection of HCV infection in hemodial‐ysis patients .For the specimens of positive RNA ,the joint detection had the highest detection rate (P<0 .05) ,the antigen level in the antigen positive specimens was positively correlated with the RNA copy number in the corresponding specimens (r=0 .85 ,P<0 .05) ,while the antibody level in the antibody positive specimens had no statistical difference between the RNA positive group and the RNA negative group(P>0 .05) .Conclusion The joint detection of HCV antigen antibody can effectively increase the detection rate of hepatitis C infection in hemodialysis patients .At the same time the HCV core antigen detection also can be used as one of monitoring indicators for the HCV re -infection in the patients with antibody positive .

[Objective] A randomized control ed trial of traditional Chinese medicine recipe Gujing Tang treatment of premature ejaculation was studied. [Methods] The subjects: 60 patients with premature ejaculation form department of andrologic outpatient, the patients were randomly divided into two groups, Integrated TCM-WM Groups and paroxetine Groups. 30 cases in each group. The Integrated TCM-WM Groups were given Gujing Tang , with paroxetine 10mg, oral, Qd at the same time; The paroxetine groups were given paroxetine 10mg, oral, Qd. Both groups were treated for 3 months. Ejaculation status was evaluated at the timepoint:before treatment, 3 months after treatment,and fol ow-up evaluation of six months after treatment. Evalu-ate parameter including Intravaginal ejaculation latency(IELT) and score of sexual function and Chinese patients with premature ejaculation evaluation -5 (CIPE-5). [Results] After 3 months, both groups were significantly improved, and Integrated TCM-WM Groups improved more significantly. After 6 months of fol ow-up, IELT, motion times and CIPE-5 score of Integrated TCM-WM Groups decreased slightly, but stil had significant difference com-pared to before treatment, and this parameter of Paroxetine groups was returned to the level of baseline, and had no significant difference compared with baseline. [Conclusion] Traditional Chinese medicine Recipe Gujing Tang combined with paroxetine, could not only have rapid onset, enhance patient confidence, improve the psychological state, but also improve the long-term efficacy and avoid recurrent disease after treatment, therefore can achieve ef-fective treatment of premature ejaculation.

Objective To report 2 cases of acute rejection following small intestin vivotransplantation and to disscuss the diagnostic significance of endoscopy and mucosal biopsy.Methods Endoscopic observation and mucosal biopsies of the graft through the terminal ileum enterostomy were carried out. Results Acute rejection was diagnosed in two patients with human small intestin vivotransplantation in good time.Endoscopic and the pathologic manifestations of the graft during acute rejection were discribed.Conclusion Endoscopy and the pathologic examination of endoscopically guided mucosal biopsy specimens are the most reliable method for diagnosing acute rejection following small intestin transplantation.

In addition to kill tumor cells through direct cytotoxicity, the immunomodulatory activity is another facet of chemotherapy. The major molecular mechanisms of immunogenicity of cytotoxic drugs are elimination of CD_4~+ CD_(25)~+ regulatory T cells or Myeloid-Derived Suppressor Cells, and sensitization of tumor cells to immune effectors through modulation of death receptor expression. These studies provide scientific evidence for combinatorial treatments including vaccines and Traditional Chinese Medicine for cancer therapy.

Objective To observe the effect of Huanyuan Injection on TNF－ α 、 sIL－ 2R in patients with acute Intracranial hemorrhage.Method Sixty patients were randomly selected and divided into two groups.TNF－ α 、 sIL－ 2R in the blood of the patients were observed before and after therapy with Huanyuan Injection.Result Increasing level of TNF－ α 、 sIL－ 2R could be detected,at the same time,Huayuan Injection could react on the differentiation.Conclusion The effect of Hyanyuan Injection on the levels of TNF－ α 、 sIL－ 2R may show some insight on its therapeutic mechanism for acute hemorrhage stroke.

Cardiomyopathy, Dilated ; genetics ; Lamin Type A ; genetics

Objective] The article analyzed the application of qi transformation for diagnosis and treatment in clinic from four aspects: theory, method, formula and herbs. [Methods] Wang Kungen is instructor of the fourth,fifth project of academic experience inheriting the old Chinese medicine experts. Director Wang believes that the Qi transformation is the fundamental of everythings,including the humanbody.To analyze the relationship between qi transformation and theory-method-formula-herbs in clinical TCM based on the study of Huangdi Neijing and textual works of famous Chinese physicians. [Result]Qi transformation is the foundation of life, therefore the foundation of health. Abnormal Qi transformation leads to process and development of diseases, so the key to the treatment is to achieve the condition of“seizing the mechanism of disease and keeping qi in harmony”through all methods, rather than holding on to specific treatments like acupuncture and herbs. [Conclusion]Qi transformation is not only an important content of TCM theory system, but also the key point of treatment in clinic, and the core clinical theory of Director Wang.