Medicine, Chinese Traditional

Medicine, Chinese Traditional

Purpose To evaluate ultrasonography in diagnosis of high recurrence risk gastrointestinal stromal tumors (GIST) by retrospective studying the ultrasound (US) imaging features of GITS. Materials and Methods US features of 72 GIST cases confirmed histopathologically were retrospectively studied. The tumor size, shape, boundary, echogenicity and blood flow of GITS were observed and compared with the results of histopathology. Results Of all the 72 tumors, 34 were originated in the stomach, 14 in the intestine, 2 in the colon, 8 in the rectum, 9 in the mesentery, 1 in the posterior peritoneum, 1 in the omentum and 3 huge masses of non definite origin. There were 7 cases with very low recurrence risk, 14 cases with low risk, 11 cases with intermediate risk and 40 cases with high risk. High recurrence risk group showed no statistical difference in heterogeneous hypoechoes and blood flow (P>0.05), but showed significantly higher rates in following US features:size larger than 5.0 cm, irregular shape, obscure boundary and cyst-solid echogenecity (P<0.001), which showed the sensitivity of 95.0% (32/40), 72.5% (29/40), 25.0% (10/40), and 55.0% (22/40), respectively; and the specificity of 59.4% (19/32), 81.3% (26/32), 90.6% (29/32), and 87.5% (28/32), respectively. Conclusion US can serve as a mean of screening GIST. The recurrence risk can be evaluated based on the tumor size, shape, boundary and echogenecity to guide clinical decisions and prognosis evaluation.

Patients who have received coronary artery interventional therapy exhibit visible anxiety and depression, which is closely related to prognosis and life quality. Therefore, for coronary artery stent patients,exception of anticoagulation and antihyperlipedemic drugs, psychological support, cognition therapy and distorted behavior rectification should be applied. The medication of anti-anxiety or depression is of great importance in ameliorate mental state, relieve mental load, as well as enhance prognosis of patients.

Objective To understand the effect of environment variables on anxiety in the soldiers at high altitude.Methods A total of 267 soldiers at high altitude were investigated with the self-rating anxiety scale,the environmental scale and Eysenck personality questionnaire.Results Compared with norm(29.78±0.46),the soldiers at high altitude had higher sore of anxiety(37.22±6.64;t=17.92,P＜0.01).One-way ANOVA and independent.samples t test showed that the anxiety(38.37±5.93,36.65±6.951,36.75±6.88)of military people at high altitude had not evidently difference in different altitude(≥3587.5m,3587.5～2767.9m,≤2767.9m).Parental culture.length of military service(F=3.25,P＜0.05)and neuroticism(R=0.52,P＜0.01)had evidently effect on the depression of soldiers.Conclusion The occurrence of anxiety in the soldiers at high altitude has a higher level.Parental culture.1ength of military service and neuroticism had predictive value for depression.

A large number of epidemiological studies have indicated that periodontal disease and ischemic stroke have a certain correlation, which may be its independent risk factor, but the exact mechanism is not fully understood. This article reviews the epidemiological studies of periodontal disease and ischemic stroke as well as its possible mechanism of action.

OBJECTIVE:To study the compatible stability of doxofylline for injection with cefoperazone sodium/sulbactam sodium for Injection. METHODS:The contents of 2 constituents in the mixed solution stored at (25?1)℃ within 6 hours were determined by dual ultraviolet wavelength spectrophotometry,and the appearance and pH value of the mixture were compared with those before mixing. RESULTS:There was no significant change in the content of doxofylline after mixing,while the contents of cefoperazone sodium and sulbactam sodium showed a slight reduction. No significant change was noted for other indexes. CONCLUSION:Doxofylline injection is compatible with cefoperazone sodium and sulbactam sodium for injection in 0.9% sodium chloride injection at 25℃ within 4 hours' mixing.

Objective To investigate the immunoregulatory effects of immunonutrient ?-3 polyunsaturated fatty acid (PUFA) and its applications in organ transplantation. Methods Relevant literatures of recent years were reviewed. Results The immunoregulatory effects of ?-3 PUFA can inhibit proliferation and activation of the immunocompetent cells including T cell and B cell, reduce cytokine production, modulate immunologic response, improve graft function, pro-long survival, reduce episodes of rejection, and lessen adverse reactions of immunosuppressor.Conclusion ?-3 PUFA should have wide applications in organ transplantation due to its immunoregulatory effects. However, this research should be further studied.

Objective:To detect the expression of 5-LOX and observe its inhibitory effect in humane pancreatic cancer cell.Methods:5-LOX mRNA and protein expression were analyzed by RT-PCR and immunocytochemical staining as well as images analyzing system,and the effect of MK886 was tested.Results:MK886 effectively down-regulated the expression of 5-LOX mRNA.Immunocytochemical staining and images analysis confirmed that the expression 5-LOX protein in cell treated with MK886 was lower than untreated control cell.Conclusion:Inhibitor of 5-LOX can effectively prevent the target mRNA into protein product,thus block or weaken the expression of 5-LOX.

Objective To research the tissue structure changes of vessels wall in the patients with liver cirrhotic portal hypertension and to investigate the role of inducible nitric oxide synthase (iNOS) in development process of liver cirrhosis.Methods The left portal vein,left hepatic artery and left hepatic vein (n=27) were collected from the patients with liver transplantation as the case group and the corresponding vessels of traumatic hepatectomy were collected as control group (n=15).HE staining and Masson staining were performed respectively.The hepatic arteries were stained with elastic fibers and immunized with anti-human iNOS polyclonal antibody.Results Compared with the control group,the portal vein intima and tunica media in the case group were thickened,the smooth muscle cells of tunica media were hyperplasia and hypertrophy,partial smooth muscle cells protruded into the intima;the irregular proliferation of hepatic arterial intima,arterial luminal stenosis,internal elastic membrane flatten,and even fracture,the tunica media smooth muscle hyperplasia to the intima were also observed;no obvious structural changes were observed in the hepatic vein wall.The higher expression of iNOS was found in the cytoplasm of hepatic artery smooth muscle cells (P<0.01).Conclusion The walls of liver artery and portal vein in the patients with liver cirrhosis would secondarily develop the tissue structure reconstruction,which is the results of human body′s own compensatory mechanism,the higher expression of iNOS accelerats the occurrence and development of the tissue structure reconstruction.