1.Clinical and pathological analysis of autopsy-confirmed invasive fungal disease in elderly patients
Yanming LI ; Xuefeng ZHONG ; Yang JU ; Fang FANG ; Tieying SUN
Chinese Journal of Geriatrics 2015;34(3):270-273
Objective To compare and analyze clinical and pathological data of autopsyconfirmed invasive fungal disease (IFD) in elderly patients in order to achieve a better understanding of the clinical and pathological characteristics of IFD.Methods A total of 18 cases of IFD were diagnosed by autopsy from 1984 to 2014 at Beijing Hospital.Clinical and pathological data of IFD,including risk factors,clinical manifestation,X-ray and pathological characteristics,were analyzed retrospectively.Results The 18 cases were all male wvith an average age of (83.7±7.2) years and each patient had at least one risk factor for IFD.Of them,14 patients (77.8%) suffered malignancies of various origins.With respect to the pathogens,Mucor (6 cases) was the most common one,followed by Aspergilla (4 cases),Mycotoruloides (4 cases) and Cryptococci (2 cases).The lung was the most frequently implicated organ wvith 13 cases (72.2%),followed by the gastrointestinal tract.Vascular erosion was an important pathological characteristic of fungal infection,whose presentations included vasculitis,hemorrhage and embolism in tissues and organs.14 patients died from fungal infection-related causes,of which.massive hemorrhage as a result of vascular erosion by fungal infection was responsible for four patients' deaths.Conclusions Malignancies are an important risk factor for invasive fungal disease in elderly patients.Vascular erosion is a significant character of fungal infection.
2.Impact of Rehabilitation Training, Acupuncture-moxibustion Combined with Danshen Chuanxiongqin Acupoint Injection on the Patients with Shoulder-hand Syndrome after Cerebral Infarction
Junli GAO ; Xichi JU ; Dingan LI ; Jian ZHONG ; Mingxiu ZHANG
Progress in Modern Biomedicine 2017;17(27):5267-5270
Objective:To observe the impact of rehabilitation training,acupuncture-moxibustion combined with Danshen Chuanxiongqin acupoint injection on the patients with shoulder-hand syndrome (SHS) after cerebral infarction (CI).Methods:82 patients with SHS after CI from March 2014 to March 2016 in our hospital were randomly divided into the group A and the group B (n=41).Patients in the group A received comprehensive drug therapy,acupuncture and rehabilitation training,the group B was given Danshen Chuanxiongqin acupoint injection therapy based on the group A.Before and after treatment,the upper limb movement function score (FMA),digital pain score (NRS),the degree of swelling in the shoulder joint,shoulder joint of motion (ROM),and neural function defect scale (CNFDS),daily life activities ability (MBI) and quality of life scores (WHOQOL) of patients in two groups were compared and analyzed.Results:After treatment,the scores of NRS,shoulder swelling,upper extremity CNFDS were significantly higher than those before treatment,the ROM,while the upper extremity FMA,MBI and WHOQOL of both groups were significantly decreased (P<0.05),these index improved more significantly in group A than those of group B (P<0.05).Conclusion:Rehabilitation training,acupuncture-moxibustion combined with Danshen Chuanxiongqin acupoint injection was more effective in the treatment of SHS after cerebral infarction than rehabilitation training and acupuncture-moxibustion.
3.Thoughts of Clinic Practice Teaching for Pediatrics Undergraduates on Basic Hospital
Xinran CHENG ; Xiaojing LI ; Wenguang HU ; Ju WU ; Youquan ZHONG
Chinese Journal of Medical Education Research 2006;0(11):-
To explain how to ensure and improve the quality of the clinical practice teaching for the clinical institutes,we expatiate on the practical experience in the hospital from enhancing the practice teaching management,improving the teaching consciousness,meliorating the teaching environment and reforming the method.
4.Nosocomial Infections due to Staphylococcus aureus:Clinical Characteristics and Resistance Analysis
Li-Chun WANG ; Da-Jiang LI ; Zhong-Hua XIONG ; Xiao-Ju LV ; Bing-Jun LEI ;
Chinese Journal of Nosocomiology 2004;0(10):-
OBJECTIVE To investigate the risk factors,clinical characteristics and resistance of Staphylococcus aureus nosocomial infections so as to guide the treatment of S.aureus infection.METHODS To collect clinical materials of S.aureus nosocomial infection and analyze risk factors and clinical characteristics and detect sensitivity of isolated strains to antibacterial agents.RESULTS Severe underlying diseases existed among 73 cases of S.aureus nosocomial infections,82.19 percent of patients had received invasive interventions.Lower respiratory tract was the most common infective site.Seventy-nine strains of S.aureus were isolated,including 66 meticillin-resistant S.aureus(MRSA) and 13 meticillin-sensitive S.aureus(MSSA).S.aureus showed general resistance to many kinds of antibiotic drugs.The resistant rates of MRSA were much higher than those of MSSA(P
6.Infantile rhabdomyofibrosarcoma.
Hong-feng TANG ; Tian-lin WANG ; Wei-zhong GU ; Long LIN ; Min-ju LI
Chinese Journal of Pathology 2005;34(9):607-608
Actins
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metabolism
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Back
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Desmin
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metabolism
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Diagnosis, Differential
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Fibrosarcoma
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pathology
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Humans
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Infant
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Male
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Neoplasm Recurrence, Local
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Reoperation
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Rhabdomyosarcoma
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drug therapy
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pathology
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surgery
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Vimentin
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metabolism
7.Risk Factors of Central Venous Catheter Related Sepsis in Total Parenteral Nutrition: Analysis of Logistic Regression
Shu-Shan FAN ; Zhao-Ju LV ; Shou-Guo ZHAO ; Jian-Zhong CHEN ; Xia LI ; Jin ZHANG ;
Chinese Journal of Nosocomiology 1994;0(01):-
OBJECTIVE To analyze risk factors in order to provide scientific gist in diagnosis and treatment of central venous catheter related sepsis(CRS) in patients with total parenteral nutrition(TPN). METHODS To make comparison of the 57 cases of CRS with 423 cases of non-CRS during 1998-2002.First,monovariable chi-square test and then non-condition Logistic regression analysis of the markedly different factors in SPSS10.0 were conducted. RESULTS The major risk factors might be infectious disease,duration of central venous catheter in,location of catheter, type of catheter and material of catheter,and serum protein
8.Effects of voriconazole on proliferation and morphology of Acanthamoeba cultivated in vitro
Yuehua WANG ; Xiaohong JU ; Xiuhong ZHONG ; Qiang LI ; Yanmei SUN ; Xiaoming JIANG
Journal of Jilin University(Medicine Edition) 2017;43(3):518-521
Objective:To explore the effects of voriconazole on the proliferation and morphology of Acanthamoeba cultivated in vitro,and to clarify the killing effects of voriconazole against the trophozoites and cysts of Acanthamoeba.Methods:The Acanthamoeba polyphaga at logarithmic phase were selected and divided into control group and experiment groups(2.5 and 25.0 mg·L-1).The Acanthamoeba in each group was collected at 24,48,72,and 96 h after drug administration,respectively.Then the concentrations of Acanthamoeba were calculated and the proliferation curves were drawn;inverted microscope was used to observe the morphology,activity and adherence of Acanthamoeba;the ultrastructures of Acanthamoeba were observed under electron microscope.Results:Compared with control group,the numbers of Acanthamoeba polyphaga in experiment groups were significantly decreased(P<0.01).The morphology of Acanthamoeba changed significantly under inverted microscope,and the shape of Acanthamoeba transformed from the trophozoites with irregular spiny filopodia to circular cysts.Even a large number of cell debris was observed.Different degrees of damage and even necrosis of Acanthamoeba in experiment groups were found under electron micro scope.Conclusion:Certain concentration of voriconazole can effectively inhibit the proliferation of Acanthamoeba and change the morphology and ultrastructure and kill the trophozoites and cysts of Acanthamoeba cultivated in vitro.
9.X-ray diagnostic site selectivity studies of skeletal fluorosis
Heng-xiang, LI ; Xue-song, WANG ; Pei-zhong, CHEN ; Jie, GAO ; Ju-mei, HUANG
Chinese Journal of Endemiology 2013;32(5):565-568
Objective To study the X-ray signs of forearm and leg in skeletal fluorosis and its diagnostic value,aim at finding the easy examination parts.Methods One thousand four hundred and forty subjects were examined using developed shield,darkroom and other portable dedicated device combined with a small X-ray machine.A total of 384 cases were diagnosed skeletal fluorosis.All patients were divided into different groups and the time,degree and range of X-ray to the forearm and calf elbow,knee,and long bone were compared.Results The X-ray change in the forearm elbow was earlier than that of the leg knee,and trabecular bone change was the earliest indicator,197 cases and 157 cases,respectively,and the difference was statistically significant (x2 =28.006,P < 0.01).Membrane ossification of forearm backbone was earlier than that of the leg,and most of them were degree Ⅰ photos,213 cases and 126 cases respectively.The difference was statistically significant (x2 =17.626,P < 0.01).The direction of the interosseous membrane ossification was from the forearm radius to the ulna,then to the fibula and tibia,and was accompanied by changes in the aggravation of forearm.A variety of indicators were observed,especially the membrane ossification in bone and joint trabecular bone and the long bone was the most active,and the forearm was more sensitive,obviously than that of the calf.Conclusion In the X-ray screening or detection of endemic fluorosis,the forearm radiography is a simple,economical,and effective diagnostic method.
10.An investigation of dental fluorosis of children aged 8 - 12 in Wushan and Fengjie counties of Chongqing
Ju, YAN ; Zhao-hui, ZHONG ; Ying-xiong, WANG ; Xing-jian, LUO ; Wei, YAN ; Li-hong, MU
Chinese Journal of Endemiology 2012;31(4):423-425
ObjectiveTo investigate the prevalence and distribution characteristics of dental fluorosis of children aged 8 - 12 in Wushan and Fengjie counties of Chongqing and to provide a scientific basis for prevention and control of the disease.MethodsTwenty townships(towns) in Fengjie county and 18 in Wushan county were selected as survey points by random cluster sampling in 2010.Dental fluorosis of all the children aged 8 - 12 was examined with Dean index.The detection rate of children's dental fluorosis,defect rate and dental fluorosis index were compared between the two counties.Results Totally 38 209 children aged 8 - 12 were investigated.The total detection rate of dental fluorosis was 43.09%( 16 466/38 209) in the two counties.The detection rates of dental fluorosis in Wushan and Fengjie were 48.98% (9397/19 186)and 37.16%(7069/19 023),respectively,and the difference was statistically significant(x2 =544.03,P < 0.01 ).Total detection rates of dental fluorosis of the five age groups(8,9,10,11,and 12-year-old age groups) were 32.52%(2157/6632),40.07%(2672/6668),43.67%(3420/7831 ),46.01% (3861/8391) and 50.14% (4356/8687),respectively,and the difference was statistically significant (x2 =510.50,P < 0.01),Dental fluorosis indexes in Wushan and Fengjie were 0.713 and 0.485,respectively.Defect rates of dental fluorosis in Wushan and Fengjie were 4.05% (777/19 186) and 1.57%(298/19 023),respectively.Conclusions The total detection rate of dental fluorosis of the two counties is still high,which gradually increases with age.Wushan is still an endemic area of dental fluorosis,and Fengjie is at the edge of the