Microglia(MG)is recognized as the main immune effector in central nervous system injury and disease.MG can regulate the tumorigenesis and development of brain metastases tumor(BMT)by different ways.Studing the roles and mechanisms of MG in BMT will provide new insights into the prevention and treatment of BMT.

Cytokines play an important role in the genesis and development of tumor.Antitumor mechanisms of some cytokines are clearly testified.Currently,the main cytokines used in tumor clinical treatments are interferons,interleukins and tumor necrosis factors.For the lack of specificity,there are too many side effects for some patients to continue.So the application range of cytokines in tumor clinical treatment is limited.The most important measures to develop cytokines therapy are improving the stability of curative effect and reducing side effects.

Objective To study the efficacy and safety of laparoscopic high ligation of indirect inguinal hernia in children. Methods From February 2006 to February 2008,totally 260 children with indirect inguinal hernia underwent laparoscopic high ligation in our hospital.Two trocars were used to ligate the inner circle.Results The procedure was completed successfully in all of the cases.The mean operation time was 22 minutes(range,15-45 minutes).A 2-to 23-month follow-up(mean 11.6 months) was achieved in 259 of the patients.During the period,no patient showed incisional hernia,iatrogenic cryptorchidism or atrophy of the testicles,or intestinal adhesion.One patient showed recurrent hernia in 5 months after the surgery(0.4%). ConclusionLaparoscopic high ligation of indirect inguinal hernia is a minimally invasive,effective,and safe procedure for children.

objective: To study the stress distribution of abutment dentin of mandibular complete overdenture based on post core abutment(COBPA). Methods: 3 D FEM was employed to investigate the stress distribution of abutment dentin of mandibular COBPA and natural abutment(NA) on standard model, the data were compared. Results: In the same loading condition, stress concentration was observed at the root end area of dentin in both COBPA and NA. When post core was applied decreased stress distribution area and increased stress value were found aroud tooth neck, decreased stress concentration was found at root end. Conclusion: In COBPA and NA the stress may be transferred to the root end along the axis. Apart from retention, post core can transfer and buffer the stress, change the way of stress transfer, and may result in cervical fracture.

Adult ; China ; Female ; Humans ; Occupational Health Services ; Women's Health Services ; Young Adult

Fast pyrolysis experiments of corn stalk were performed to investigate the optimal pyrolysis conditions of temperature and bed material for maximum bio-oil production under flue gas atmosphere. Under the optimized pyrolysis conditions, furfural residue, xylose residue and kelp seaweed were pyrolyzed to examine their yield distributions of products, and the physical characteristics of bio-oil were studied. The best flow rate of the flue gas at selected temperature is obtained, and the pyrolysis temperature at 500 degrees C and dolomite as bed material could give a maximum bio-oil yield. The highest bio-oil yield of 43.3% (W/W) was achieved from corn stalk under the optimal conditions. Two main fractions were recovered from the stratified bio-oils: light oils and heavy oils. The physical properties of heavy oils from all feedstocks varied little. The calorific values of heavy oils were much higher than that of light oils. The pyrolysis gas could be used as a gaseous fuel due to a relatively high calorific value of 6.5-8.5 MJ/m3.
Biofuels ; Biomass ; Bioreactors ; Furaldehyde ; chemistry ; Hot Temperature ; Kelp ; Temperature ; Xylose ; chemistry ; Zea mays

Objective To investigate changes of serum levels of interleukin(IL)-4,-6,-8 and tumor necrosis factor-?(TNF-?),and probe their clinical significance in children with Henoch-Schonlein purpura(HSP)/ HenochSchonlein purpura nephritis(HSPN).Methods Serum levels of IL-4,-6,-8 and TNF-? of 45 children with HSP/HSPN and 43 healthy children were examined by enzyme linked immunosorbent assay(ELISA),changes and correlation between the aforementioned cytokines in children with HSP /HSPN were analyzed.Results 1.Serum levels of IL-4,-6,-8 and TNF-? of children with HSP were higher than those of control group(P0.05);The serum level of TNF-? was positively correlated to the serum levels of IL-6,-8 of patients with HSP(r=0.670 P

Objective:To study the stress distribution of periodontal supporting tissues of mandibular complete overdenture based on post-core abutment. Methods:3-D finite element method (FEM) was employed to investigate the stress distribution of periodontal supporting tissues of mandibular complete overdenture based on post-core abutment, the stress values of periodontal membrane and lamina dura were calculated and compared with those of natural abutment. Results:The values of stress in distal area of abutment were larger than that in medial area. Post-core reduced periodontal membrane stress value in distal area of abutment cervix dentin, as well as that in apical zone, increased the stress value in distal periodontal membrane of the middle part of root, raised the stress value of distal lamina dura of abutment cervix dentin, while reduced the stress value below the cervix dentin. Conclusion:Abutment tends to incline distally. Post-core can influence stress distribution of periodontal membrane and lamina dura and reduce the stress value on root-end.

Objective To investigate the value of high-frequency ultrasound in diagnosis of thyroid carcinoma by comparative analysis of high-frequency ultrasound and spiral CT imaging results. Methods The imaging results of patients with thyroid carcinoma proved by postoperative pathology or biopsy results were reviewed.High-frequency ultrasound and spiral CT were used to examine the 35 patients in The Tumor Hospital of Harbin Medical University between 2007 and 2009. Results Diagnosis of thyroid carcinoma by application of Highfrequency ultrasound were 27 cases, diagnosis rate was 77.1%(27/35);by spiral CT were 25 cases, diagnosis rate was 71.4% (25/35);comparison of the two methods showed no significant difference (x2= 0.3, P ＞ 0.05). Combined application of high-frequency ultrasound and spiral CT diagnosed 33 patients with thyroid carcinoma, diagnosis rate was 94.3%(33/35), which was significantly higher than that of high-frequency ultrasound alone or that of spiral CT alone(compared with high-frequency ultrasound, x2 = 4.2, P ＜ 0.05;and spiral CT, x2 = 6.4, P ＜ 0.05). Conclusion Combined application of high-frequency ultrasound and spiral CT can improve the diagnosis rate of thyroid carcinoma.