Objective To investigate the effect of irinotecan hydrochloride combined with cisplatin on B-cell lymphoma-2 (Bcl-2) and metastasis-associated in colon cancer-1 (MACC1) protein expressions in cervical epithelial tissue of cervical cancer patients.Methods 100 patients with cervical cancer from January 2010 to January 2013 in Department of Obstetrics and Gynecology of Shangrao City People's Hospital were selected as objects.All patients were treated with irinotecan hydrochloride and cisplatin for combination chemotherapy.The clinical effect and the protein expressions of Bcl-2 and MACC1 of cervical epithelial tissue were compared pre-and post-chemotherapy.Results The total efficiency was 75.0%(75/100) after cervical cancer patients were given irinotecan hydrochloride combined with cisplatin chemotherapy program.The expressions and high expression rates of Bcl-2 and MACC1 post-chemotherapy were significantly lower than that pre-chemotherapy(P<0.05) .In clinically effective group, the high expression rates of Bcl-2 and MACC1 post-chemotherapy significantly reduced than pre-treatment (P<0.05), and in clinical invalid group, the difference of the high expression rates of Bcl-2 and MACC1 had no statistically significant.Conclusion After combination chemotherapy with irinotecan hydrochloride and cisplatin on cervical cancer, the expression of Bcl-2 and MACC1 in cervical epithelial tissue significantly reduce, and the clinical efficacy is aignificant.

Adult ; Chronic Disease ; Female ; Humans ; Kidney Transplantation ; adverse effects ; Male ; Middle Aged ; Nasal Polyps ; etiology ; Postoperative Complications ; Sinusitis ; etiology

Acute Kidney Injury ; blood ; diagnosis ; etiology ; Child, Preschool ; Humans ; Hyperuricemia ; blood ; complications ; Kidney ; pathology ; Magnetic Resonance Imaging ; Male ; Uric Acid ; blood

Objective To discuss the selection of approaches for CT-guided percutaneous biopsy of thoracic and lumbar spine. Methods One hundred and forty-one cases of thoracic (70 cases) or lumbar (71 cases) vertebral undiagnosed lesions underwent CT-guided percutaneous biopsy. Appropriate needle approaches were designed according to different locations of lesions in the vertebra, including 63 cases of paravertebral path, 45 cases of transpedicular path, 11 cases of transcostovertebral path, and 22 cases of other paths. Results Out of the 141 cases, a definite diagnosis was obtained in 128 cases. The diagnostic accuracy of biopsy was 90.8%. No complications occurred. Conclusions The needle approach for CT-guided percutaneous biopsy of the thoracic and lumbar spine should be selected according to different locations of lesions, which should be based on principles of safety, enough specimen, and minimally invasive to patients.

Objective To analyze the selection of puncture needles in CT-guided percutaneous biopsy in musculoskeletal system diseases.Methods Three hundred and sixty-four undiagnosed lesions of musculoskeletal system underwent CT-guided percutaneous biopsy from January 1996 to March 2005.Proper selection of different puncture needles,including biopsy gun,bone biopsy needle,or both,was made according to different locations and characteristics of the lesions.Results Among 255 lytic lesions,the biopsy gun alone was used in 47 cases and both biopsy gun and bone biopsy needle were used in 208 cases.Among 73 mixed lesions,the bone biopsy needle alone was used in 49 cases,biopsy gun alone in 14 cases,and both in 10 cases.The bone biopsy needle was used in all 36 sclerotic lesions.Enough specimens were obtained in all the cases,and no complications occurred.A correct biopsy diagnosis was made in 334 cases,the diagnostic accuracy of biopsy being 91.8%(334/364). Conclusions The puncture needles for CT-guided percutaneous biopsy of the musculoskeletal system lesions should be selected according to different locations and characteristics of lesions.For sclerotic lesions or lesions containing relatively more sclerotic contents,the bone biopsy needle should be used.For lytic lesions,the biopsy gun should be used.And the combined use of both bone needle and biopsy gun should be utilized for mixed lesions.

Objective To assess the clinical value of color doppler sonography in the evaluation of effects of uterine artery embolization(UAE) for the treatment of uterine fibroid.Methods Twentythree patients with symptomatic uterine fibroid were given transvaginal color Doppler sonography before and 1~7 days,1~3 months and 6~12 months after the UAE.Measurements of the uterus,myomas,and resistance index(RI) of the uterine artery were obtained. Results Out of 21 patients examined at 1~7 days after UAE,the uterus volume increased by a mean of 10% in 7 patients(4%~63%) and decreased by a mean of 21% in 14 patients(1%~67%) with the dominant myoma decreased by 24% in size(1%~56%).In 21 patients examined at 1~3 months after embolization,the uterus and dominant myoma decreased in size by 53%(24%~82%) and 47%(6%~88%),respectively.In 19 patients examined at 6~12 months,the uterus and myoma decreased in size by 66%(5%~91%) and 71%(32%~99%),respectively.Vessels inside and surrounding the myoma remarkably diminished or completely disappeared after embolization.No statistically significant changes in uterine artery RI were noted before and after UAE(F=0.47,P=0.70).Symptomatic improvements were achieved in 87% of patients(20/23) at 1 year after UAE. Conclusions UAE for the treatment of symptomatic uterine fibroid is safe and effective.Color Doppler sonography can evaluate the effect of UAE by means of measuring the volume of the uterus and myoma and the hemodynamic changes of the uterine artery before and after embolization.

Objective To explore the clinical diagnositic code(CDC)in ovarian endometrial cysts (OEC).Methods 218 cases of pelvic masses were investigated by use of symptoms,signs,B mode sonography and CA125.172 cases were diagnosed with OEC out of 218 cases,While 46 cases were ruled out by combination exploratory laparotomy and laparoscopy.Meanwhile we compared it with revisional american fertility society(r-AVS)including diagnosis and staging.Results The operation results of 218 cases were compared with the results of CDC and its Diagnositic Sensitiveness;Specificness;Positive predictive value;Negative predictive value;Diagnositic accordance rate as well as Diagnositic index of CDC were 96.4%,79.6%.93.0%,90.0%,91.7% and 73.4% respectively(χ2=127.818,P＜0.001).Further more,172 cases of OEC which diagnosed with CDC were further subdivided into three stages as 1,2,3 according to its score,mild;moderate;heavy and this stage category were compared with the category of AFS(Ⅰ-Ⅱ,Ⅲ,Ⅳ),the Diagnositic accordance rate of two categories were 95.6%,95.6% and 83.0% respectively,No significant difference were found in Var.mitis and medium-sized(χ2=0,P＞0.05).but the Medium-sized and Gravis tape was significance(χ2=4.472,P＜0.05).Conclusion CDC has a better coincidence with operation in the diagnosis of OEC which can be used in the non-traumatic diagnosis and staging of OEC in clinic.

As an essential part of all kinds of medical relations,the physician-patient relationship should be developed following the unceasing progress of medical modes.Patients were provided with the respect for their legal rights,dignity,freedom and personality with humanistic treatment and nursing care.With ethical and moral principles,such as patient first principle,body and mind unified principle,confidentiality principle,impartial treatment principle,optimization principle,medical informed consent principle,coordination principle and the principle of striving for perfection,patients' psychological state was taken into full consideration during perioperative period.Humanistic care is embodied by humanistic treatment and nursing care during perioperative period,and patients are provided with sympathy,encouragement and psychotherapy.The physician-patient relationship is improved and a harmonious medical atmosphere enhanced through humanistic caring.

Modernization of theories of traditional Chinese medicine (TCM) is a key issue for the development of Chinese medicine. As TCM concepts are too vague and lack precise definition, it is difficult to test those theories by modern technologies. Methods of TCM classification are not accepted by Western medicine so far. Because of the diversity and complexity of Chinese herbal medicines, the molecules of Chinese herbal medicines are difficult to be separated, and efficacy is difficult to be verified and classified by biological and chemical methods. In order to verify the scientificity of TCM classification, molecular properties can be studied by their spectrum, and be combined with latent semantic analysis technology and weighting method which are widely used in the Internet search engine. 48 Chinese herbal medicines belonging to four kinds of Chinese herbal medicines:nourishing yin, tonifying yang, invigorating qi, and enriching blood, are analyzed through NIRS, and the results are almost the same as the TCM classification.

Objective To evaluate the relationship between serum bilirubin and carotid atberosclerosis in aged patients with hypertension.Methods 141 aged patients with hypertension were detected by ultrasound were divided into in- creased IMT group,atberoma group and narrow luminal diameter group.Their serum bilirubin levels were measured and compared.Results Those with lower serum total bilirubin,Serum direct bilirubin and serum indirect bilirubin showed more severe carotid atherosclerosis.There was significant statistical difference between threeg roups (P