Congresses as Topic ; Head ; surgery ; Neck ; surgery ; Otolaryngology ; Periodicals as Topic

Objective To describe the epidemiological characteristics and the control effect of hypertension in Liaoning area.Methods 8 452 Residents aged 15 and above 7 districts,Liaoning province,were selected with the multistage clustering sampling in 2002.Trained staff conducted the investigation on their economic status,gender,occupation,education,marriage,smoking,drinking,occupational physical activities and so on.Blood pressure,height,weight and waist circumstance were also measured.Results The blood pressure of all subjects was(126?22)/(79?12)mm Hg,with(127?11)/(80?11) mm Hg in urban residents and(125?21)/(78?12) mm Hg in rural residents,while(128?21)/(80?12)mm Hg in male and(125?23)/(78?11)mm Hg in female.The general prevalence of hypertension was 29.4%,and the general standardized rate of hypertension was 22.5%.The prevalent rate in city(32.3%) was higher than that in city(25.4%)(P

Objective To promote the cure rate of operation and to decrease the operative complications in patients with upper urinary tract stone Methods The data of 962 patients with upper urinary tract stone operatively treated in our department from 1975 to 2002 were reviewed and analyzed Results Residual stones were found in 109 out of 673 patients (11 3 %) Of the 109 cases, conservative treatment, nephrectomy and various methods of treatment were performed in 21, 12 and 76 cases, respectively Conclusion Strict control of operative complication, proper selection of the operation type and reasonable management of the complication are the important measures to improve the cure rate of upper urinary tract stone, to greatly decrease the occurrence of residual stones and to reduce the possibility of nephrectomy

OBJECTIVE: To explore the clinical efficacy of functional endoscopic sinus surgery (FESS) associated with radiofrequency ablation on chronic sinusitis. METHOD: Fifty-four patients with chronic sinusitis were divided randomly into two groups: the study group and the control group, The study group received FESS associated with inferior turbinate lateral fracture and radiofrequency ablation treatment, while the control group received FESS associated with inferior turbinate lateral fracture treatment. RESULT: The SNOT-20 score, Lund-Kennedy score, mucociliary clearance time and nasal airway resistance of the patients in the two groups after treatment were significantly improved than those before treatment (P < 0.05), and the sense of nasal congestion, headache and face pain, purulent rhinorrhea, postnasal drip, and other symptoms were also relieved. After treatment, the scores of SNOT-20 and the scores of Lund-Kennedy in the study group were significantly lower than those in the control group (P < 0.05), but no significant difference was found in mucociliary clearance time between the two groups after treatment. CONCLUSION FESS associated with radiofrequency ablation surgery is safe and effective for chronic sinusitis.
Catheter Ablation ; Chronic Disease ; Endoscopy ; Humans ; Mucociliary Clearance ; Rhinitis ; surgery ; Sinusitis ; surgery ; Turbinates ; surgery

Humans ; Liver Diseases ; drug therapy ; prevention & control ; Oleanolic Acid ; analogs & derivatives ; therapeutic use ; Phytotherapy ; Saponins ; therapeutic use

Objective To observe the inhibition effect of selective cyclooxygenase-2 inhibitor (celecoxib) on the experimental choroidal neovascularization (CNV).Methods Thirty 8-10 weeks old healthy male Brown-Norway(BN) rats were randomly divided into the control,laser and celecoxib group,with 10 rats in each group.At the dosage of 50 mg/kg,celecoxib was garaged twice per day.After 7 days,experimental CNV was induced by Krypon laser on laser group and celecoxib group.Fundus fluorescein angiography (FFA) was performed on days 3,7,14,21,30 after laser photocoagulation.On days 21 after photocoagulation,5 rats in each group were sacrificed and the relative thickness of CNV membranes,the expression of COX-2,vascular endothelial growth factor(VEGF) and matrix metalloproteinase-2 (MMP-2) Were studied by histopathologic or immunohistochemistry examination.Results On days 21 after photocoagulation,the incidence of CNV in the celecoxib group is significantly lower than that in the laser group (X~2=7.1068,P=0v0077);the relative thickness of the CNV membranes in the celecoxib group is reduced 41.38% compared to the laser group,the difference is statistically significant (t=16.7600,P=0.0000).COX-2,VEGF and MMP-2 expression in the CNV membrane of celecoxib group were significantly lower than in control group (t=5.7100,5.8400,8.0200;P=0.0000);the COX-2,VEGF and MMP-2 expressions in choroid and retina of control group were weak.Conclusion Prophylactic celecoxib can reduce the expression of VEGF and MMP-2 by inhibiting COX-2,and prevent the CNV induced by laser photocoagulation.

?Objective: To study the effects of endogenous bone morphogenic protein 2(BMP 2) and 6(BMP 6) in rat facial nerve after injury. Methods: Facial nerve trunk was cut and then anastomosed in 30 adult male Sprague Dawley rats,another 6 rats without operation were used as the controls. Every 6 rats were killed 6 ,72 h,1, 2 and 4 weeks respectively after operation and nerve specimens were immunohistochemically examined for BMP 2 and BMP 6 expression. Result:In the control nerve the gray level of BMP 2 and BMP 6 were 210.89?8.21 and 232.03?9.25 respectively. 6, 72 h,1, 2 and 4 weeks after operation the gray level of BMP 2 were 242.83?11.01,240.67?7.91,234.46?5.28,232.12?7.27 and 220.71 ?10.19;that of BMP 6 210.75?5.19,204.08?10.85,198,91?8.58,186.37?4.11 and 184.62? 8.45 ,respectively. Conclusion: BMP 2 may play a role in the early irritable actions when facial nerve was injured. However, BMP 6 might have functions in the regeneration of facial nerve during later period after injury.

Objective: To construct a high effective eukaryotic expre ss ing vector containing mcpr1 gene. Methods: mcpr1 gene w as amplified by PCR from the plasmid T-easy/ mcpr1, then PCR product was in serted into eukaryotic expressing vector pcDNA3.1/V5-His B. The positive recomb inant was identified by PCR analysis, HindIII and BamHI restriction analysis and Sequence analysis. Results: A 400 bp DNA fragment was amplified from the recombinant. Sequence analysis and restriction digest demonstrated tha t the mcpr1 gene was successfully inserted into pcDNA3.1/V5-His B plasmid. Conclusion: The eukaryotic expressed vector pcDNA3.1/V5-His B/ mcpr1 has been successfully reconstructed.

Xiao Zhi Ling Injection is a Chinese herbal aqueous solution of praeparatum which is mainly made of gallnut and alum, it can make a " strengthening body resistance " treatment in polytype tumors, mainly through promoting apoptosis of tumor cells, destructing tumor cells, inhibiting tumor growth, enhan-cing immunity of organism and so on, the clinical effect is certain, with the development of theory and tech-nology in tumor molecular biology, it has become the core of future research that how to further explore Xiao-Zhi-Ling injection to promote tumor cell apoptosis by impacting on related genes, and its lucubrate inevitably provide new hope in gene therapy of cancer.