Objective To explore the changes and clinical significance of iron metabolism indexes such as serum ferritin (sFn),serum transferritin (sTf),serum transferritin receptor (sTfR) in patients with hematologic malignant disease before and after treatment.Methods Fifty-nine patients with hematologic malignant disease were enrolled.We measured the blood routine,bone marrow routine and iron bound of bone marrow cells and sFn、sTf、sTfR before and after treatment.The control group was 43 healthy Volunteers.Result Before treatment the level of patients sFn increased obviously,which was higher than that of control significantly (P ＜ 0.05).After chemotherapy,the level of sFn in remission group decreased obviously,which was still higher than that of normal control.sFn expression in non-remission group was not different from that before therapy or normal control (P ＞ 0.05).The level of sTf was lower than that of control significantly pretreatment and aftertreatment (P ＜ 0.05).While there was no different between remission group and nonremission group after chemotherapy (P ＞ 0.05).The level of sTfR in non-remission group after chemotherapy was higher than that of control.Correlation analysis showed that there was positive correlation between the serum level of sFn and the original and naive bone marrow cells (r =0.347).And there was negative correlation between sFn and hemoglobin (r =-0.207).But there was no significant correlation between sFn and bone marrow iron.Conclusions It is possible to predict treatment response and prognosis in hematologic malignant disease by the decrease of sFn after chemotherapy.But sTf and sTfR are not good indexes to predict treatment response in a short time.Prevalence of anemia among patients with tumor was not only because of iron deficiency.So iron supplementation should be cautious.

Objective To study the chemical constituents in ethanol extract from the carpophore of Xanthoceras sorbifolia and explore a new potential part.Methods The constituents were isolated by macroporous resin and silica gel column chromatography and their structures were elucidated by the phisi-cochemical properties and spectral evidence.Results Compounds Ⅰ-Ⅵ wre obtained and their structures were identified as 21-angeloyl-24-hydroxy-R1-barrigenol(Ⅰ),23-hydroxybetulinic acid(Ⅱ),3?,23-dihydroxy-lup-20(29) en-28-oic acid-3-caffeate(Ⅲ),22,23-dehydroxy-?-chondrillasterone(Ⅳ),3-oxotirucalla-7,24-dien-21-oic(Ⅴ),and ?-spinasterol-3-O-?-D-glucopyranoside(Ⅵ),respectively.Conclusion Compound Ⅰ is a new natural product and compounds Ⅱ-Ⅳ are isolated from the plants of Xanthoceras Bunge for the first time.

Excellent teaching team is basic guarantee of top-quality course construction. In order to improve the teaching team construction in dermatology,a lot of work has been done on the team construction,professional degree of medicine,quality construction,etc. As a results,the quality of dermatology teaching team has been greatly improved in the Department of Dermatology of West China Hospital,Sichuan University,which is the basis for the following top-quality course construction.

Objective To develop a double-wavelength HPLC method for the simultaneous determination of neogambogic acid,gambogic acid,( +)-catechin and L-epicatechin in Litong pill. Methods The quantitative analysis was carried out on C18 column(250 mm×4.6 mm,5 μm).A linear elution of methanol-acetonitrile(4: 1)and 0.2% phosphoric acid solution was adopted at the flow rate of 1.1 mL·min-1 ,with the detection wavelength set at 360 nm for neogambogic acid and gambogic acid,and at 280 nm for(+)-catechin and L-epicatechin. Results The linear ranges of neogambogic acid,gambogic acid,(+)-catechin and L-epicatechin were 5.85-117.00 μg·mL-1(r= 0.999 5),8.95-179.00 μg·mL-1(r= 0.999 8),6.90-138.00 μg·mL-1(r= 0.999 7),and 5.30-106.00 μg·mL-1(r = 0.999 9),respectively.The average recoveries were 97.82%(RSD= 1.21%),98.72%(RSD = 1.30%),96.96%(RSD = 0.84%)and 99.26%( RSD = 1.46%)for neogambogic acid, gambogic acid,(+)-catechin and L-epicatechin,respectively. Conclusion The method is simple,accurate,reproducible and may be used for the simultaneous determination of neogambogic acid,gambogic acid,(+)-catechin and L-epicatechin in Litong pill.

Objective To investigate the clinical application of low dose chest CT examination with PACS/RIS-HIS-Health screening system.Methods 6038 subjects underwent chest low-dose CT examination were retrospectively analyzed in this study. With or without PACS/RIS-HIS-Health screening system,the physical examination workload per day,average examination duration and waiting duration were retrospectively calculated and compared,respectively.Results At the same working hours,the low dose chest CT screening workload was sharply increased from 73.87 to 127.4 per day (t=11.526,P<0.001).The mean CT examina-tion duration was decreased from 2.58 to 1.8 minutes per subject (t=8.443,P<0.001).30 percent of waiting duration were saved approximately (t=6.951,P<0.001).All the related management departments could do statistics and analyze the data online with high efficiency via the screening system.Conclusion PACS/RIS-HIS-Health screening system can optimize the workflow and im-prove the work efficiency of chest low-dose CT screening.

Six taxane diterpenoids were isolated from the stem bark of Tax us cuspidata Sieb. et Zucc.. On the basis of physical and chemical properties and spectra analysis,they were identified as 2'-de sacetoxyaustrospicatine(Ⅰ). taxol(Ⅱ),cephalomannine (Ⅲ), 2-deacetoxyl taxinine J (Ⅳ),taxinine B(Ⅴ) and 10-deacetyl-7-0-?-Dxylosyl-taxol (Ⅵ).

Purpose To observe the ultrasonographic features of periventricular-intraventricular hemorrhage (PIVH) in preterm infants, to evaluate the value of cranial ultrasound for early diagnosis of PIVH. Materials and Methods 555 cases of premature children underwent bedside cranial ultrasound examination, characteristics of their ultrasound images were retrospectively analyzed and categorized with Papile grading, gradeⅢandⅣPIVH were defined as severe bleeding. Results 125 PIVH cases (22.52%) were detected by ultrasound, of which 111 cases (88.8%) were Papile gradeⅠ, manifested as hyperechoic group localized in the rear and below lateral ventricle anterior horn and in the sulcus of hypothalamic caudate nucleuscaudate;7 cases (5.6%) were Papile gradeⅡ, manifested as increased echogenicity, irregular widen or isolated mass shadow of the choroid plexus within the triangle zone and posterior horn of the lateral ventricle;7 cases (5.6%) were Papile gradeⅢ, manifested as hyperechoic group within the lateral ventricle with ventricular dilatation. 7 cases (1.26%) were severe PIVH. Overall incidence rates of PIVH in premature children whose gestational age was <32 weeks and ≥ 32 weeks were 45.05% and 16.89% respectively; overall incidence rates of PIVH for preterm infants whose birth weight were <1500 g and ≥ 1500 g were 44.16% and 19.04%, overall incidence of PIVH of preterm infants with gestational age<32 weeks and birth weight<1500 g was significantly higher than their contemporaries with gestational age≥32 weeks and birth weight ≥1500 g, and the differences were statistically significant (χ2=40.334, 23.978; P<0.01). Conclusion Incidence of PIVH becomes higher when the gestational age of preterm child is smaller and the birth weight is lower. Performing routine cranial ultrasound examination for preterm infants is important for early diagnosis of PIVH and Papile grading, thus will instruct the clinical intervention in early stage.

Rhinitis,sinusitis,nasal polyps and bronchial asthma are common respiratory diseases,and they have some similarities in etiology,pathogenesis,histopathology and pathophysiology.Many patients suffer from these diseases in succession,or at the same time.Many domestic and international clinical and fundamental studies have aroused widespread concern about the relevance of these diseases,with the correlations between nasal polyps-sinusitis and asthma that attribute to much attention.However,the relevance of extent on the study of these diseases,as well as diagnosis,treatment,and concept is not very clear yet.The main target of this article is to discuss the above issues and remind our clinicians to pay more attention to understand the comprehensive relationships of rhinitis,sinusitis,nasal polyps and bronchial asthma,and provide references for the strategy of rational and effective treatment options.

Objective: To study the effect of low-dose dopamine on splanchnic DO_2/VO_2.in rabbit SMAO shock Method:Twenty rabbits were randomly devided into two groups:group A with dopamine,group B as control group. In group A dopamlne was infused at a rate of 5?g?kg~(-1)?min~(-1). SMAO shock model was induced in both groups. Cardiac output index(Cl),portal venous blood flow index (QpvI),mean arterial pressure (MAP),arterial. artiaI and portal venous blood gas analysis.arterial and portal venous serum lactate concentrations(ALT,PLT), total oxygen delivery/oxygen consumption (TDO_2/TVO_2), splanchnic oxygen delivery/oxygen consumption (SDO_2/SVO_2). oxygen extraction ratio(O_2ER) were measured respectively. Result: QpvI, SDO_2,SVO_2 were higher in group A than those of group B (P0.05). CI,MAP, TDO_2/TVO_2 decreased. TO_2ER and SO_2ER increased in both of groups during shock, but without significant differences between both groups. Conclusion: Low-dose dopamine has beneficial effects by increasing portal venous blood perfusion and improving splanchnic oxygenation during SMAO shock in rabbits. but no effects on systemic oxygenation of shock.