OBJECTIVE:To provide reference for clinical safe administration and drug instruction revision through analyzing 552 cases of ADR/ADE induced by Sodium aescinate for injection. METHODS:Using“aescinate”and“ADR”as search words,re-trieved from CBM,CNKI,VIP and Wanfang database,47 literatures were included according to inclusion and exclusion criteria. The data was extracted and analyzed statistically. The drug instructions of twelve domestic pharmaceutical enterprises were analyzed statistically. RESULTS:The ADR/ADEs may involve multiple organs and systems,the most common reactions were venous irritant reactions as phlebitis,venous injury,etc. The drug instruction lacked some parts of information. CONCLUSIONS:Great impor-tance should be attaches to ADR/ADEs caused by Sodium aescinate for injection,and improvement of the drug instruction to en-sure the safety of drug use in the clinic.

BACKGROUND:Titanium-niobium al oy holds high biomechanical strength and low elastic modulus that is close to the human cortical bone, so it has been extensively used as implant materials of dental, orthopedics and artificial hip joints. OBJECTIVE:To observe the biomechanical strength and cytocompatibility of porous titanium-niobium al oys with different porosities. METHODS:Porous titanium-niobium al oys with the porosity of 40%and 70%were prepared using powder metal urgy technology. Afterwards, the pore size, elasticity modulus and compressive strength of the two al oys were detected. Then the rabbit bone marrow mesenchymal stem cel s were seeded onto the 40%and 70%porous titanium-niobium al oys, and cel adhesion and proliferation were observed at 3, 24 and 72 hours after inoculation, respectively. RESULTS AND CONCLUSION:Pore size of porous titanium-niobium al oys with rough surface was 200-500μm, and both main pore size was 350 and 400μm, and there was three-dimensional connectivity between the pores;in the 70%group, honeycombed pores were partly fractured, and connected mutual y;pores distributed unevenly and there was little communication between the pores in the 40%group. In addition, both groups had high compressive strength and low elastic modulus, but there was no difference between the two groups. Furthermore, both two al oys promoted cel adhesion, and the number of cel adhesion in the 70%group was significantly higher than that in the 40%group (P<0.05), and extracel ular matrix could be found in the 70%group. These results show that porous titanium-niobium al oy with the porosity of 70%is significantly conducive to cel adhesion.

Objective To explore the value of biopsy of lymph nodes alongside of internal jugular vein in surgery for papillary thyroid carcinoma(PTC) patients at CN 0 stage.Methods Clinical data of 103 PTC patients with operation at CN 0 stage were retrospectively analyzed.The lymph node ratio alongside of internal jugular vein was counted,and factors,such as gender,age,tumor size,capsular foreign invasion were analyzed.Results Of all 103 cases of papillary thyroid carcinoma at CN 0 stage,32 cases had lymph node metastasis alongside of internal jugular vein(31.1％).Meanwhile 31 cases had the thyroid capsule invasion,and 21 cases had lymph node metastasis alongside of internal jugular vein(67.7％).The rest 72 cases had no the thyroid capsule invasion,and 11 cases had lymph node metastasis alongside of internal jugular vein(15.3％),the difference was statistically significance(x2 =27.85,P ＜ 0.05).Conclusion Routine biopsy of lymph nodes alongside of internal jugular vein is necessary of papillary thyroid carcinoma patients at CN 0 stage.Whether the thyroid capsule is invased which is important factors affecting lymph node metastasis alongside of internal jugular vein.

Objective:To investigate the clinical characteristics, diagnosis, and treatment of primary pancreatic lymphoma (PPL). Methods:Clinical data of six PPL cases diagnosed and treated in the Tianjin Medical University Cancer Hospital were retrospectively analyzed. Results:In all cases, the primary clinical manifestations were abdominal pain, jaundice, and weight loss. The tumor marker level, including CA19-9, of all the cases was within the normal range, with five of the cases misdiagnosed as pancreatic cancer and one misdiagnosed as stomach cancer. In three cases, the pancreatic mass was located at the head of the pancreas, whereas in the other three, the mass was located at the body or tail. Pancreaticoduodenectomy was conducted in one case, laparotomy and biopsy in three cases, and B ultrasound-guided biopsy in the other two cases. All cases were diagnosed as PLL (B cell type non-Hodgkin's lymphoma). Ex-cept for one patient who left the hospital after surgery, the other five underwent chemotherapy. In addition to the death in one case be-cause of postoperative gastrointestinal bleeding, the survival times were 133, 73, 35, 12, and 10 months in the remaining cases. Conclu-sion:PPL is extremely rare in clinical practice, and the treatment methods and prognosis for the disease significantly differ from those for pancreatic cancer. PPL is easily misdiagnosed in clinical practice, which results in unnecessary treatment measures.

AIM:To established a method for determining geniposide and baicalin in four preparations cantaining Fructus gardeniae and Radix Scutellariae by HPLC.METHODS:The separation was performed on Lichrospher C_ 18 column;using water-phosphoric acid(53∶0.2)and acetonitrile as a mobile phase,gradient elution.The detection wavelength was 240 nm.The flow rate was at 1.0 mL/min.The column temperature was at room temperature.RESULTS:The linear range of geniposide was in the range of 1.9-76 ?g/mL,r=0.999 9,the average recovery was 101.3%.The linear range of baicalin was 10.58-423 ?g/mL,r=0.999 9,the average recovery was 100.6%.CONCLUSION:This method is rapid,sensitive and accurate.It indicates that geniposide and bai-calin in traditional Chinese medicine preparations can be determinated simultaneously,and the method can be used for quality control.

Objective Surgical treatment is the first choice for treatment in pituitary adenomas except for prolactinomas?In part of patients after operation would occur hypopituitarism,which with acute adrenal crisis is the most serious, and chronic adrenal insufficiency is different degree affects the patient's quality of life?Therefore,it is very important to accurately assess the hypothalamic pituitary adrenal( HPA) axis in patients with pituitary adenoma?But there is still a lack of reliable methods for evaluating adrenal axis?We reviewed the harm of adrenal insufficiency,HPA axis evaluation method of the new progress and postoperative glucocorticoid replacement treatment of new ideas, cleared the importance of reassessment and regular follow?up and the development of individual programs.

Objective: To study the relationship between the level of hyaluronic acid(HA) in peritoneal fluid in patients with gastric cancer and the invasion or diffusion of the cancer. Methods: The concentration of peritoneal fluid hyaluronic acid (PFHA) was determined by RIA in 48 patients with gastric cancer prior to and after operation. The PFHA from 23 non carcinoma patients were taken as control. The peritoneal fluid was obtained by the implantable Infuse Port. Results: The average PFHA level of gastric cancer group[(913.01?170.69) ?g/?g] was significantly higher than that of the non carcinoma control [(362.39?168.82) ?g/?g]. The PFHA concentration were significantly higher in groups of pTNM Ⅲ+Ⅳ [(1 094.42?127.65) ?g/?g] than that in groups of pTNM Ⅰ+Ⅱ [(814.03?232.22) ?g/?g]. The PFHA level in the radical resection group was significantly reduced a month after operation, and there were no significantly changes in patients received palliative resection. Conclusion: These findings suggest that the elevation of PFHA may be related to the peritoneal invasion and diffusion potential of gastric cancer. The PFHA level shows a decreasing tendency in patients received radical resection.

Objective To investigate the efforts of CD4+ CD25+ regulatory T (Treg) cell adjustment of Treg cells proportion in peripheral blood of patients with gastric cancer before or after surgery.Methods The peripheral blood samples were collected from 10 healthy volunteers,58 gastric cancer patients 2 days before and 7 days after operation.The proportion of Treg cells in peripheral blood were detected by flow cytometry.Results CD4+ CD25+ Treg cell in peripheral blood of patients with gastric cancer increased significantly compared with that of healthy control group (1.1±0.4) ％ / (1.5±0.5) ％ (P ＜ 0.05),and further increased after operation (1.5±0.55) ％ / (1.9±0.8) ％ (P ＜ 0.01).Conclusion The anti-tumor activity in gastric cancer patients is inhibited and surgery may be involved immune defection to decrease this effort.

Objective To evaluate the effects of Lipo prostaglandin E1(Lipo-PGE1) on the lower limb blood vessel in diabetic patients.Methods The study was performed in 36 patients with diabetes related lower limb vascular disease.Before and after Lipo-PGE1 treatment for 28 days,vascular diameter and blood flow velocity of femoral artery,popliteal artery,posterior tibial artery and dorsal pedal artery were measured by Doppler ultrasonography examination.Results After the treatment with Lipo-PGE1,the vascular diameters of femoral artery,popliteal artery,posterior tibial artery and dorsal pedal artery were dilated;and there were significant differences in posterior tibial artery and dorsal pedal artery.After the treatment with Lipo-PGE1,blood flow velocity of femoral artery,popliteal artery,posterior tibial artery and dorsal pedal artery were increased,however,there were no significantly statistical differences.After the treatment with Lipo-PGE1,all the patients feel well.Painless walking distance and maximal walking distance of 18 patients with intermittent claudication were increased.Conclusion Lipo-PGE1 causes a significant improvement of diabetes related lower limb vascular disease.Furthermore,the results demonstrated the major effects on posterior tibial artery and dorsal pedal artery.Lipo-PGE1 can dilate the smaller artery,which is important and helpful for patients to improve symptoms and signs.

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