1.Clinical and Genetic Studies on Giant Axonal Neuropathy
Journal of Applied Clinical Pediatrics 2006;0(15):-
A in GAN gene cause the phenotype of GAN in the proband.The girl′s parents are heterozygotes of the disease without symptoms.There may be other mode of inheritance in family 2.
2.Research advance in the etiology of West syndrome.
Chinese Journal of Contemporary Pediatrics 2010;12(2):159-161
1-Alkyl-2-acetylglycerophosphocholine Esterase
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genetics
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Chromosome Aberrations
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Humans
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Infant
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Infant, Newborn
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Ion Channels
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physiology
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Melanocyte-Stimulating Hormones
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genetics
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Microtubule-Associated Proteins
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genetics
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Mutation
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Neurons
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physiology
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Neuropeptides
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genetics
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Spasms, Infantile
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etiology
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genetics
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Tumor Suppressor Proteins
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genetics
4.Expert's Comment.
Chinese Journal of Pediatrics 2011;49(8):616-617
Female
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Humans
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Male
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Sepsis
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complications
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Wernicke Encephalopathy
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diagnosis
5.Changes of IL-18 and sFas/sFasL in Sera From Patients with SLE
Xiangxiong ZHENG ; Ping LI ; Shiwen ZOU
Journal of Chinese Physician 2001;0(02):-
Objective To investigate the relationship between IL-18 and apoptosis in patients with SLE by using testing the changes of IL-18 and soluble Fas/soluble Fas ligand in sera from the patients.Methods 58 patients with SLE were divided into three groups according to their SLEDAI score;sera from 58 patients,and 30 normal controls were tested for IL-18 and sFas/sFasL using ELISA assay.Results The level of IL-18 and sFas in sera from SLE patients was significantly higher than that of normal controls(P0 05).Besides,the increased level of IL-18 was correlated well with the increased level of sFas (?=0 496,P0 5).Conclusion The increased level of IL-18 may result in the elevation of serum sFas/sFasL in patients with SLE.They may play important roles in the pathogenesis of SLE.
6.Rippling muscle disease in children.
Chinese Journal of Pediatrics 2005;43(2):156-158
7.Clinical study on spinal cord injury without radiologic abnormality in children.
Yun WU ; Li-ping ZOU ; Fang FANG
Chinese Journal of Pediatrics 2006;44(2):144-145
Adolescent
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Child
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Child, Preschool
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Diagnosis, Differential
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Female
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Follow-Up Studies
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Humans
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Infant
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Magnetic Resonance Imaging
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Male
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Retrospective Studies
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Spinal Cord
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pathology
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Spinal Cord Injuries
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diagnosis
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diagnostic imaging
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etiology
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pathology
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Spine
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diagnostic imaging
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Tomography, X-Ray Computed
8.Effects of FLAG regimen and IA regimen for acute myeloblastic leukaemia cells on P-glycoprotein-positive and P-glycoprotein-negative
Quan LI ; Jian ZHANG ; Ping ZOU
Journal of Leukemia & Lymphoma 2009;18(2):69-71
Objective To explore in vitro effects and the mechanism for FLAG regimen compared with IA regimen in P-glycoprotein-positive and -negative acute myeloblastic leukemia(AML) cell lines. Methods The expression of P-glycoprotein in K562 and K562/A02 cells were analyzed by flow cytometry. The effects of FLAG and IA on the proliferation of K562 and K562/A02 cells were detected by MTT assay. The Ara-CTP and Ara-C levels in those cells were measured by HPLC,the gene expression of hENT1 in K562 and K562/A02 cells was detected by real-time PCR. Results The positive rates of P- glycoprotein were (1.32±0.24)% in K562 cell and (97.66±3.77)% in K562/A02 cell, respectively. The expression of P- glycoprotein had no change after treated with FLAG or IA. The cytotoxicity to K562 of IA was better than FLAG [(84.41±9.33) % v.s (73.17±13.20)%, P<0.05], and the cytotoxicity to K562/A02 of FLAG was better than IA [(70.55±11.32)% v.s (48.46±12.81)%, P<0.01]. Ara-C and Ara-CTP accumulation and hENT1 expression in AML cells treated with FLAG were higher than that treated with IA. Conclusion P-glycoprotein-positive AML cells are more sensitive to FLAG regimen than IA regimen. The biochemical modulation of Ara-CTP and Ara-C may be the major mechanism.
9.A candidate tumor suppressor gene RIZ1
Xiaojian ZHU ; Qiubai LI ; Ping ZOU
Journal of International Oncology 2012;39(1):3-6
The retinoblastoma-protein-interacting zinc finger proteinl (RIZ1),a methyltransferase,contains the characteristic PR zinc finger domain.RIZ1 can methylate H3K9 of the histone,acted as a transcription suppression factor of cancers.Increasing numbers of human cancers are reported to hold decreased or absent RIZ1 expression,which is closely related to the progression of cancer.RIZ1 is defined as a candidate anti-oncogene.The mechanisms of the suppression involved in both oncocytogenetics and epigenetic changes.
10.Case no. 107--Onset with fever, drowsiness and convulsion.
Tong-li HAN ; Li-ping ZOU ; Lin LUO
Chinese Journal of Pediatrics 2003;41(3):234-235
Child, Preschool
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Diagnosis, Differential
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Female
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Fever
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diagnosis
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Humans
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Seizures
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diagnosis
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Sleep Stages