Helicobacter pylori(Hp)is one of the most frequently seen pathogenic bacteria in human beings. Hp infection is closely related to the occurrence and development of chronic gastritis,peptic ulcer and gastric cancer. Therefore,eradication of Hp is very important for the prevention and treatment of such diseases. This article reviewed the progress in research on therapeutic regimen for Hp eradication.

Background: Helicobacter pylori (Hp) infection is associated with a variety of gastrointestinal diseases.Studies have shown that Hp eradication rate may be affected by the disease type and stage of disease progression.Aims: To investigate the influence of endoscopic ulcer stage on Hp eradication rate.Methods: A total of 423 peptic ulcer (PU) patients with Hp infection from January 2015 to July 2016 at the People's Hospital of Xinjiang Uygur Autonomous Region were enrolled.Of them,133 were gastric ulcer (GU) and 255 were duodenal ulcer (DU).A 14-day bismuth quadruple therapy was given for Hp eradication,and the eradication rates were analyzed with the endoscopic ulcer stage.Univariate analysis was conducted to identify factors influencing the eradication rate.Results: There was no significant difference in Hp eradication rates between GU and DU groups (82.7％ vs.83.9％,P>0.05).The eradication rates according to endoscopic ulcer stage were significantly different in GU group (active stage vs.inactive stage: 89.0％ vs.75.0％,P＜0.05);but in DU group,the eradication rate in active stage was similar to that in inactive stage (85.6％ vs.83.0％,P>0.05).Univariate analysis revealed that ulcer stage was correlated with the success rate of eradication;the eradication rate in active stage was significantly higher than that in inactive stage (87.8％ vs.80.3％,P＜0.05).Conclusions: Endoscopic ulcer stage is correlated with the Hp eradication rate in PU,especially GU patients.Hp eradication therapy performed in patients with active PU could yield a higher eradication rate.

Humans ; Osteogenesis, Distraction ; instrumentation

Objective To investigate the effect of SM on aquaporin-1(AQP-1) expression in rats with acute lung injury(ALI) induced by lipopolysaccharide(LPS). Method 48 SD rats were randomly divided into normal group,ALI 7-day group,ALI 8-hour group,SM prevention group,SM 7-day treatment group,and SM 8-hour treatment group,8 rats per group. At 8 hours and 7 days after treatment,lung wet to dry weight ratio,lung pathology,electron microscope,AQP-1 immunohistochemistry,and AQP-1 Western blotting were performed. The situation of hemorheology and serum level of PaO2 and Endothelin-1(ET-1) were also detected. Results The model group rats all appeared ALI symptom. Compared with the 7-day ALI group,the degree of lung edema statement alleviated in SM 7-day treatment group. But the expression difference of AQP-1 was not significant between the two groups(P

Objective To investigate the metabolism characteristics and CD34 variance of SD rats models with type 2 diabetes renal injury with high grease feeding and low-dose STZ injection. Methods 60 male SD rats with 4-week old were randomized into two groups:10 in the control group feeding with normal forage,50 in the DM group feeding with high grease forage,which consist of 10% lard,10% glucose,1% cholesterol,2% yolk powder,and 1% sodium cholate adding into the normal feeds. Intravenous injection of STZ after feeding 4 weeks (35 mg/kg). All the rats were tested with OGTT after 10 days and 30 days injection of STZ. Serum insulin was measured by radioimmunoassay (RIA) and immunohistochemistry staining was adopted to observe the positive expression of renal CD34 molecular. Results FBG of rats with diabetes and renal injury was significantly higher than that in the control group (P

Objective To sdudy the effects of Melatonin(MT)on cognition and tau hyperphosphorylation in hippocampus of Alzheimer's disease(AD)model rats.Methods A?25-35 was injected into the hippocampus to make AD model rat.MT was injected intraperitoneully into rats of MT group 7 days before and 19 days after modeling.Normal saline(NS)was injected intraperitoneully into rats of AD group after modeling.The cognition was tested by Morris water maze.The pathological changes of hippocampus was observed by Bielschowsky staining and the tau hyperphosphorylation was detected by immunohistochemistry staining.The results were compared with normal control group.Results In MT group,the results of Morris water maze were significant better than those in AD group(all P

Using the field sampling and indoor soil cultivation methods, the dynamic of ginseng rhizosphere soil microbial activity and biomass with three cultivated ages was studied to provide a theory basis for illustrating mechanism of continuous cropping obstacles of ginseng. The results showed that ginseng rhizosphere soil microbial activity and biomass accumulation were inhibited observably by growing time. The soil respiration, soil cellulose decomposition and soil nitrification of ginseng rhizosphere soil microorganism were inhibited significantly (P <0.05), in contrast to the control soil uncultivated ginseng (R0). And the inhibition was gradual augmentation with the number of growing years. The soil microbial activity of 3a ginseng soil (R3) was the lowest, and its activity of soil respiration, soil cellulose decomposition, soil ammonification and soil nitrification was lower than that in R0 with 56.31%, 86.71% and 90. 53% , respectively. The soil ammonification of ginseng rhizosphere soil microbial was significantly promoted compared with R0. The promotion was improved during the early growing time, while the promotion was decreased with the number of growing years. The soil ammonification of R1, R2 and R3 were lower than that in R0 with 32.43%, 80.54% and 66.64% separately. The SMB-C and SMB-N in ginseng rhizosphere soil had a decreased tendency with the number of growing years. The SMB-C difference among 3 cultivated ages was significant, while the SMB-N was not. The SMB of R3 was the lowest. Compared with R0, the SMB-C and the SMB-N were significantly reduced 77.30% and 69.36%. It was considered by integrated analysis that the leading factor of continuous cropping obstacle in ginseng was the changes of the rhizosphere soil microbial species, number and activity as well as the micro-ecological imbalance of rhizosphere soil caused by the accumulation of ginseng rhizosphere secretions.
Agriculture ; Ammonium Compounds ; metabolism ; Bacteria ; growth & development ; Biomass ; Cellulose ; metabolism ; Nitrification ; Panax ; growth & development ; microbiology ; Plant Roots ; growth & development ; microbiology ; Rhizosphere ; Soil ; chemistry ; Soil Microbiology ; Time Factors

Adult ; Humans ; Male ; Occupational Diseases ; Pulmonary Aspergillosis

Objective To evaluate the diagnostic accuracy of ultrasound miniature probe(UMP)examination in tumor invasion(T staging) and local lymphatic node metastasis(N staging) for colorectal carcinoma. Methods Preoperative UMP examinations(12 MHz) were performed on 53 patients with colorectal carcinoma undergoing surgeries.The diagnosis accuracy of UMP examination in T and N staging was determined by comparison of the results of operation exploration and histopathologic findings. Results The accuracy in T staging for colorectal carcinoma was 86% with UMP examination,and that for early stage colorectal carcinoma was 100%.The accuracy,sensitivity and specificity in N staging for colorectal carcinoma were 81%,77%,and 84%,respectively with UMP examination. Conclusion UMP examination works well in determining T stage of colorectal carcinoma,especially for early stage colorectal carcinoma and those with tumor stenosis.

Pg.The adherence activity of periodontal pathogens to HA was enhanced by Ss and Av.When cultivated with Sm,the adherence activity of Pg was reduced.Periodontal pathogens had no effect on the adherence activity of Sm and Av,and Ss excepted. Conclusion The adherence activity of periodontal pathogens is lower than that of cariogenic bacteria.Periodontal pathogens can utilize early-attached bacteria to become those predominant bacteria in periodontal ecosystem.