Objective To observe the correlation between active vitamin D3 level and sarcopenia development in elderly patients in plateau regions and the changes in the correlation factors for sarcopenia under the invention of active vitamin D3 (Calcitriol,Cal),and to observe whether Cal could improve the muscle function.Methods 90 patients were assigned to the normal control (Con) arm,and 120 patients with sarcopenia were assigned to the sarcopenia (Sar) arm to receive different oral doses of Cal as intervention (0.25 ug/d for low dose group including 60 patients and 0.25ug bid for high dose group including 60 patients) Before and after the intervention,levels of 1,25-(OH)2D3 and the inflammatory factors TNF-α,IL-6,IL-10,and hs-CRP were detected using ELISA;HOMA-IR,BMI,and ASMI were calculated;and walking speed and grip strength were measured to observe the correlation between 1,25-(OH) 2D3 level and sarcopenia,the changes in these indicators from before to after intervention,and the efficacy and safety of oral Cal for sarcopenia.Results Prior to intervention,compared with the Con arm,1,25-(OH)2D3 level,IL-10 level,ASMI,walking speed and grip strength were significantly reduced (P＜0.01),and HOMA-IR,IL-6,TNF-α and hs-CRP were significantly elevated (P＜0.01) in both dose groups;intervention with Cal produced significant increases in 1,25-(OH)2D3 and IL-10 levels,significantly improved walking speed and grip strength (P ＜0.05),significant decreases in HOMA-IR,IL-6,TNF-α,and hs-CRP (P＜0.05),which were more marked with higher dose,but no significant changes in ASMI.From before to after intervention,there were no significant changes in BMI or hepatic/renal function,blood calcium,or blood phosphorus in either group.Conclusions The development of sarcopenia is associated with reduced 1,25-(OH)2D3 level.Cal can lower the inflammatory factors IL-6,TNF-α,and hs-CRP,and elevate IL-10,providing anti-inflammatory and immunoregulatory actions;improve muscle function and strength;and improve insulin resistance.BMI is irrelevant to the management of sarcopenia.Cal is safe at the oral dose up to 0.5 tμg/d.

Study the development of the surgery methods for breast cancer according to the biological characteristics of breast cancer. Reviewing the operations for 25years and the relative literature, I put forward the principle for choosing the methods of the surgery. The improving radical treatment for breast cancer is the first choice to hospitals. It will take time for them to keep the breasts by means of complex treatment. The surgery of breast cancer emphasize individuation, humanization, lowering hurt and justification. The complex treatment mainly by means of surgery has an effective cure in the long run.

Objective To investigate the effect of 1,6-diphosphate(FDP)on neonatal hypoxic-ischemic encephalopathy(HIE)combined with myocardial damage.Methods 62 cases of HIE in newborn with myocardial damage were randomly divided into two groups:32 cases of the treatment group and 30 cases of the control group.Control group were giren conventional treatment and the treatment group were giren FDP 250mg /(kg?d)by intravenous drip for 10 days for 1 course of treatment.Each case was tested serum creatine kinase(CK)and isoenzyme(CK-MB)within hospitalization 12 hours and after treatment.The two groups were observed with clinical symptoms and signs disappeared,the ECG changes and CK,CK-MB changes.Results Clinical signs and symptoms of treatment group disappeared soon,and serum CK,CK-MB returned to normal rate is high compared with the control group significantly.Conclusion Exogenous FDP has a certain therapeutic effect on moderate to severe HIE with myocardial damage,contributes to recovery of heart and brain function.

Objective To explore the reason and the degree of dysphoric mood of family members of children with scoliosis, and then make out some countermeasures to ameliorate these dysphoric mood. Methods Divided 64 family members of children with scoliosis into the observation group and the control group randomly. Using nursing intervention in the observation group and none in the control group. Evaluated the mood of 2 groups by the end of research by using the Zung Self-judged scale and the questionnaire. Results Different causes have induced different degree of dysphoric mood of family members of children with scoliosis. After using the nursing intervention, there were significant difference between the 2 groups in dysphoric mood, P

Objective To evaluate the accuracy of the index of consciousness (IoC) in monitoring the depth of anesthesia with sevoflurane inhalation in children,by comparing it with the bispectral index (BIS).Methods Forty-two ASA physical status Ⅰ or Ⅱ children,aged 8-12 yr,scheduled for elective abdominal surgery under general anesthesia,were studied.Anesthesia was induced with sevoflurane inhalation.The patients were endotracheally intubated.The concentration of sevoflurane was then adjusted to maintain the end-tidal concentration of sevoflurane (CETSev) at 1.6％,2.1％,2.6％,3.1％,3.6％,4.1％ and 4.6％ for5 min.The IoC and BIS values were recorded simultaneously.Results When CETSev ＜ 3.1％,CETSev was negatively correlated with IoC and BIS values,and the correlation coefficients between CETSev and IoC and BIS values were-0.927 (r1) and -0.869 (r2),respectively (P ＜ 0.01).When 3.1％ ≤ CETSev ≤ 4.6 ％,CET Sev was negatively correlated with IoC and BIS values,and the correlation coefficients between CETSev and IoC and BIS values were-0.808 (r3,P＜ 0.01) and-0.430 (r4,P ＜ 0.05),respectively.Comparison of the absolute value of correlation coefficients:there was no significant difference between r1,r2 and r3 (P ＞ 0.05) ; r1,r2 and r3 were significantly larger than r4 (P ＜ 0.01).Conclusion IoC can accurately reflect the depth of anesthesia with sevoflurane inhalation in children and when 3.1％ ≤ CET Sev ≤ 4.6 ％,the accuracy of IoC in monitoring the depth of anesthesia is superior to that of BIS.

ObjectiveTo investigate the perioperative nursing experience in patients with renal cell carcinoma treated by cryoablation.Method The clinical data of 34 patients with renal cell carcinoma treated by cryoablation were retrospectively analyzed to summarize the perioperative nursing strategies.Results All the patients lived through the operations.The complications after the surgery occurred in 7 cases,with bleeding in 4 cases,urinary fistula in 1 case and wound infections in 2 cases.All the complications were cured by active treatment.After following up for 6 months,all the tumors showed liquefaction and necrosis and no one relapse. Conclusion Active and effective nursing intervention is the key point for the success of cryoablation.

Topic selection is the first step of writing nursing research papers. The novelty of topic selection is listed as an important indicator of paper review, which plays a key role in the recruitment of papers. How to choose a topic and choose a good one is not only the concern of all authors, but also the difficulty of thesis writing. This paper mainly introduces the source and common problems of nursing research papers, aiming to help nurses to write research papers.

BACKGROUND: In traditional Chinese medicine, both deficiency as primary and excess as secondary and deficiency of qi and blood stasis are common symptoms in dialectical logy of atherosclerosis (AS). Therefore, qi-benefiting drugs are the main component of qi-benefiting and blood-activating intervention. However, the best dose relationship between qi-benefiting and blood-activating drugs needs to be further studied.OBJECTIVE: To observe the effect of qi-benefiting and blood-activating intervention on the expression of aortic vascular cell adhesion molecule-1mRNA (VCAM-1mRNA) in AS models and analyze dose-effect relationship between astragalus and sanchi.DESIGN: Randomized control animal study.SETTING: Shanxi Medical University.MATERIALS: The experiment was carried out in the Shanxi Medical University in April 2005. A total of 60 healthy male Wistar rats were selected in this study. The main reagents were quercetin (Shaanxi Huike Plant Co., Ltd., batch number:20041112), saponins of panax notoginseng (PNS, Kunming Yagechen Pharmaceutical Co., Ltd., batch number:20050118) and ligustrazine (Yuxin Guoji Longyuan Pharmaceutical Co., Ltd., batch number: 20041204).METHODS: Model establishment: Wistar rats were administrated AS feeds (including 10% yolk powder, 5% lard, 0.5% bile salt and 85% basic feed) for 3 months. Grouping and administration: At threedays after suitability feeding, 8 rats were randomly selected, regarded as the normal control group and given general feeds, and other 52 rats were fed with AS feeds. Three months later, 4 rats were randomly selected for the measurements of lipid and aortic tissue. And then, the models were established successfully. In addition, 48 rats were randomly divided into 6 groups. ① Astragalus treatment group: Rats were perfused with 0.1 g/(kg·d) quercetin. ② Sanchi treatment group: Rats were perfused with 0.1 g/(kg·d)PNS. ③ 2∶1 of astragalus/sanchi treatment group: Rats were perfused with 0.1 g/(kg·d) quercetin and 0.05 g/(kg·d) PNS.④ 3∶1 of astragalus/sanchi treatment group: Rats were perfused with 0.15 g/(kg·d) quercetin and 0.05 g/(kg·d) PNS. ⑤Ligustrazine treatment group: Rats were perfused with 0.2 g/(kg ·d) ligustrazine (Yuxin Guoji Longyuan Pharmaceutical Co., Ltd.). ⑥ Normal control group: Rats were fed with general feeds. ⑦ Model group: Rats were fed with general feeds after successful model estalishement. Thirty days after administration, relative expression of VCAM-1mRNA inaorta was measured with reverse transcription polymerase chain reaction (RT-PCR) technique; moreover, 2 mL venous blood was collected from tail to measure the levels of serum total cholesterol (TC), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C).MAIN OUTCOME MEASURES: ① Relative expression of VCAM-1mRNA in aorta; ② level of lipid.RESULTS: Among 60 male Wistar rats, three rats in the treatment group died because of perfusion and two rats in the model group died due to accident; therefore, a total of 51 rats were involved in the final analysis. ① High-lipid diet could promote the formation of AS models. Level of lipid was higher in the model group than that in the normal control group (P＜ 0.05), and leves of serum TC, TG and LDL-C were lower in the interventions group than those in the model group (P ＜0.05). ② Expression of VCAM-1mRNA was not found in the normal control group. Expression of VCAM-1mRNA was lower in the intervention groups than that in the model group. Expression of VCAM-1mRNA (0.42±0.02) was the lowest in 3∶1 of astragalus/sanchi treatment group, and there were significant differences as compared with other intervention groups (P ＜ 0.05).CONCLUSION: Astragalus and sanchi, a main component of qi-benefiting and blood-activating herbs, can down-regulate the level of lipid and resist AS; meanwhile, the combination of them is superior to the single application; in addition, with the increasing deal of qi-benefiting drugs, the function against AS is strengthened.

Objective To build relationship model of personality, life style and mental health for medical students. Methods 869 medical students were surveyed with Eysenk Personality Questionnaire, Symptom Check List 90(SCL-90), common condition questionnaire, to describe the situation of medical students mental health and personality, and a relationship model was set up by structural equation modeling. Results The situation of mental health for medical students was well. Male students showed significantly higher lie than female students. The only children showed significant higher lie than those having siblings. Neuroticism, life style, lie, sleep time everyday, boarding and lodging in middle school, friends, only child, degree of parents attention had significant direct influence on mental health (β =0.508, 0.136, 0.100, 0.082, 0.076, -0.057, 0.057, 0.051 ). Neuroticism, friends and sleep time everyday affected mental health in an indirect way through life style (β = 0.044, - 0. 008, 0.007). Only child affected mental health in an indirect way through boarding and lodging in middle school (β = -0.026). Lie affected mental health in an indirect way through neuroticism (β =0. 195). Conclusion The important effects of personality, life style on mental health are further supported in this study.

Hyperglycemia has direct and indirect impact on the occurrence and develop-ment of stroke. At present, hyperglycemia is considered as an independent risk factor for stroke. Hyperglycemia directly involves in cellular and vascular injury through activating polyol pathway, forming advanced glycosylation end product, activating protein kinase C and the hexosamine pathway. Moreover, hyperglycemia involves in vascular injury through the indirectly pathway such as lipid metabolism, glycosylated hemoglobin and insulin. Controlling hyperglycemia may effectively reduce the incidence of stroke and improve the prognosis in patients with stroke.