Nitric oxide (NO) is a vascular endothelium-derived relaxing factor.NO inhalation therapy is widely used in the field of neonatology.When NO acts as selective pulmonary vasodilation,it can reduce pulmonary arterial pressure and improve oxygenation.When NO serves as a major regulator of cerebral vasomotor factor,it may have physiological and pathological impact in cerebral ischemia-reperfusion injury.So NO has a wide range of applications in persistent pulmonary hypertension of the newborn,bronchopulmonary dysplasia,hypoxia ischemic encephalopathy.With the recently in-depth study of NO,its biological role has more and more clinical attention in the field of neonatology and has broad valid prospects.However,NO has some side effects which still have some controversial aspects of the application in premature,especially in very low birth weight children.The article focused on the mechanism and clinical applications of NO in the neonatal disease.

Objective To investigate the clinical effect of integrated care model in improving the quality of life and enthusiasm of treatment in patients with cardiovascular diseases. Methods 60 patients in department of cardiology adopting integrated care from September 2008 to April 2011 were chosen as the observation group.60 patients with ordinary care were set as the control group.The quality of life and the situation for enthusiasm of treatment were taken for statistical analysis. Results Patients with good quality of life in the observation group was 39 cases (65.00％),more than 21 cases (35.00％) in the control group.Patients obtaining effective treatment result in the observation group was 48 cases (80.00％) and 15 cases (25.00％) in the control group,there was significant difference.It was statistical significant.Adherence to medication,reasonable diet,adequate exercise and proper understanding of disease status in the observation group were significantly better than the control group. Conclusions Application of integrated care models in nursing of disease and life of patients with cardiovascular diseases can improve the quality of life and enthusiasm of treatment of patients,which is better than general model of care.

There are multiple genes involved in the progress of evolution in breast cancer.Recent study showed that Twist gene may play key role in promoting tumor growth,invasion and metastasis through the epithelial-mesenchymal transition (EMT).Other studies also demonstrated that Twist gene expression maybe associated with patient outcomes and guiding clinical tailored therapies.

To explore the stability of impact assay for determination of microorganism in indoor air, the comparisons of continued sampling times of 2-minute and 4-minute for monitoring on microorganism of indoor air were carried out with JWL- Ⅱ B multifunctiom air microorganison monitor in 11 hotels, public places of entertainment, barbar shops and beauty shops. The results showed that, under a same environmental condition, there was no significant differences between the data obtained by 2-minute monitoring and 4-minute monitoring (t=1.854, P＞0.05).It indicated that impact assay presented very good stability in detecting the microorganism of indoor air within certaindetecting duration.

Objective To analyze the mechanism of hemiparalysis children,cerebral vessels' physiological feature of children, pathological change and therapeutic efficacy after light craniocerebral trauma. Methods To analyze clinical manifestation,imageology data,therapy and therapeutic efficacy of 32 hemiparalysis children patients after light craniocerebral trauma. Results Mon-basal ganglia cerebrel infarction was discovered in all children,and cure rate of broadening blood vessel therapy was 84% in a week after trauma. Conclusion Blood vessel spasm and thrombosis happened after light craniocerebral trauma to artery of cerebral hemorrhage that erupt perpendicularly from arteria cerebri media and had incomplete tunica intima development. Nonage broadening blood vessel therapy could gain well curative effect.

Objective To discuss the correlation between the expressions of high mobility group protein box 1(HMGB1),VEGF-C/D and lymph node metastasis in colon cancer.Methods Forty-five colon cancer samples were stained by immunohistochemical method for VEGF-C/D,HMGB1.The correlations of VEGF-C/D,HMGB1 expressions and lymph node metastasis were analyzed statistically.Results Positive HMGB1 expression was in 33 specimens,lymph node metastasis was in 27 specimens with 23 specimens of positive HMGB1 and non-lymph node metastasis was in 18 specimens with 10 specimens of positive HMGB1.Positive VEGF-C expression was in 27 specimens with 20 in lymph node metastasis.The expression of HMGB1 was consistent with VEGF-C expression,and HMGB1 and VEGF-C expressions were closely correlated with lymph node metastasis,but not with age,sex,cellular differentiation.Conclusion HMGB1 and VEGF-C expression may become predictor to the prognosis of colon cancer patients.

Objective To understand cerebral edema and development procedure of different time windows.Methods To analyze their prognosis through image document and operation findings of 52 cerebral trauma patients which were confirmed cerebral edema by CT and operation.Results he light cerebral oedema patients have a better prognosis,10 patients died and 1 patient became a plant man in 11 malignant brain dilatation patients.Conclusion The infernal circle of high brain pressure-cerebral ischemia,cerebral anoxia-cerebral edema result in cerebral edema-brain dilatation-malignant brain dilatation after cerebral trauma which leads to unremitting aggravated pathogenefic condition.So effective means should be used to interrupt the unremitting heightening ICP.

Medical lnformed Consent(MIC) is a new rule in health care practice.It is required in the Guideline of Medical Record ,which is enacted by National Ministry of Health.Our hospital puts ephasis on Medical Informed Consent Document,modify and apply it into clinical practice by improving understanding.

Objective To explore the treatment measures of gastric mucosal damage caused by gastric acid and ischemia after cerebral trauma. Methods 0 ～5 ℃ colded 5% Sodium Bicarboante solution 250 ml were infused into stomach through nasal gastric tube once and remained at least 30 minutes. Results The total effective rate was 100%. Among them,22 cases(73% )bleeding was stopped by once infusion,8 cases died(27% ) ,but the causes of . the death had no direct relation with IGU. Conclusions The result of the method was definite, satisfied, economical and easy to perform and without sideeffects. It should be the best choice for treating IGU.

A total of 23 new cancer medicines or indication expansions were approved by the U. S. Food and Drug Administration in 2012. Among these, 12 are new molecular entities (NMEs)--new chemical or biological drugs approved for the first time for oncologic use--and 10 of these NMEs are molecular targeted agents. Among the 10 targeted agents, 4 are anti-angiogenesis agents and 2 are Bcr-Abl pathway inhibitors, targeting well established targets validated by previously approved agents such as bevacizumab (Avastin) or imatinib (Gleevec). Despite this progress, several questions remain: Do these newly approved agents provide sufficient treatment options to manage the broad spectrum of cancers we deal with in the clinic? Where will the next wave of new cancer drugs come from? Where should R&D efforts be invested to continue improve cancer treatment and management, especially for tumor types uniquely prevalent in China? This editorial and the review articles in this special issue of Chinese Journal of Cancer provide an in depth review of the progress and challenges in developing targeted cancer therapies, as well as an outlook of new research areas where near term breakthroughs are expected to overcome some of these challenges.
Angiogenesis Inhibitors ; therapeutic use ; Antineoplastic Agents ; therapeutic use ; China ; Drug Delivery Systems ; Drug Discovery ; Humans ; Immunotherapy ; Molecular Targeted Therapy ; Neoplasms ; therapy