Systemic lupus erythematosus (SLE) is a kind of complex autoimmune connective tissue disease involving multi-organ and multiple systems.And the cardiovascular complication is a major cause of mortality in SLE patients.The diagnosis and evaluation depend on imaging.As a non-invasive,simplicity and repeatability method,echocardiography plays a vital role in evaluating heart structure and function.The application of echocardiography in the SLE with cardiovascular complications were reviewed in this article.

AIM:To prepare O/W microemulsion formulation containing sinomenine and investigate the effect of different penetration enhancers on transermal delivery character of microemulsion in vitro. METHODS: The microemulsions were prepared and characterized using Zetasize potential/particle size analysis instrument.The stability tests were performed to evaluate the sinomenine microemulsions.Franz diffusion cell was adopted as the apparatus for in vitro transdermal test.Excised Wistar-rat abdomen skin was pretreated with penetration enhancers,such as menthol,borneol and isopropyl myristate. RESULTS: The average droplet size of the microemulsion was about(31.3 nm.)A high permeation rate of(32.238?1.13)?g/cm~(2)?h was showed in vitro.Ail the enhancers showed significant enhancement effect on the transdermal behavior of sinomenine microemulsion.2% borneol had the strongest effect in all. CONCLUSION: These results indicate that the studied microemulsion system with high permeation rate may be a promising vehicle for the transdermal delivery of sinomenine.Menthol,borneol and isopropyl myristate were found to be the proper penetration enhancers in the transdermal preparation.

Cervical cancer is one of the most common and deadliest cancers in females worldwide. Despite the treatment methods of surgery, radiotherapy and chemotherapy are maturing, the prognosis of patients with recurrent, advanced or metastatic cervical cancer remains poor. Molecular targeted therapy provides new hope for these patients. This review focuses on the advances in agents targeting vascular endothelial growth factor pathway, epidermal growth factor receptor, mammalian target of rapamycin, histone deacetylases and cyclooxygenase-2 in cervical cancer.

ObjectiveTo investigate osteopontin (OPN) level in pulmonary tuberculosis and its clinical significance.MethodsThe level of serum OPN was determined in 80 pulmonary tuberculosis patients before anti-tuberculosis treatment[patients group,simple pulmonary tuberculosis with 60 cases (simple pulmonary tuberculosis group),pulmonary tuberculosis combined with tuberculous pleurisy with 20cases (pulmonary tuberculosis combined with tuberculous pleurisy group)],and compared with that of 30healthy persons (healthy control group) and 20 patients having received effective anti-tuberculosis treatment and followed-up for 6 months (followed-up group).At the same time,the clinical significance of OPN was studied by other commonly used clinical indicators of tuberculosis.ResultsThe level of serum OPN in patients group [(843.49 ±569.23) ng/L] was significantly higher than that in healthy control group [(352.50 ± 185.02) ng/L,P ＜0.05].The level of serum OPN after treatment in followed-up group were significantly decreased compared with those before treatment [(494.11 ±352.40) ng/L vs.(1106.60 ± 628.39) ng/L,P＜ 0.05 ] and there was no significant difference compared with those in healthy control group (P ＞ 0.05 ).The level of serum OPN in pulmonary tuberculosis combined with tuberculous pleurisy group [(1179.80 ±606.33) ng/L] was significantly higher than those in simple pulmonary tuberculosis group [(727.53 ±511.66) ng/L,P ＜0.05],and they were both higher than those in healthy control group [ ( 352.50 ± 185.02 ) ng/L,P ＜ 0.05 ].Therefore,for further additional subgroup analysis in simple pulmonary tuberculosis group,the level of serum OPN in patients with cavity[ ( 836.51 ± 549.80) ng/L ] was significantly higher than that without cavity [ (535.52 ± 375.95 ) ng/L,P ＜ 0.05 ],while the levels of serum OPN had no statistical difference between pulmonary lesion involved ＜ 3 leaf patients and ≥ 3 leaf patients,sputum mycobacterium tuberculosis positive patients and negative patients,mycoDot test results positive patients and negative patients,erythrocyte sedimentation rate elevated patients and normal patients,PPD strongly positive patients and non-strongly positive patients (P＞0.05).ConclusionsOPN activity is closely related with pulmonary tuberculosis.OPN can serve as a judge of pulmonary tuberculosis and the clinical indicators of disease outcome.The level of serum OPN and the severity of pulmonary tuberculosis have some correlations.

Objective To investigate apoptosis in acinar cells during posttransplant reperfusion, and the expression of Bcl 2, Bax, Fas Methods Pancreas transplantation was performed between male SD rats after 2 hours of cold ischemia Rats ( n =65) were divided at random into 7 groups: sham group, cold ischemia group (as controls), reperfused 1 h, 3 h, 6 h, 9 h, 12 h group The pathologic pancreatic tissue was observed by electron microscope; Apoptotic cells were stained by TUNEL technique; Expression of Bax、Bcl 2 and Fas protein in pancreatic tissue were detected by SABC immunohistochemical method Results Apoptotic cells were observed in early phase after pancreas transplantation The peak of apoptotic pancreas cells occurred 3 hours after reperfusion [AI ( 9 5? 2 9)%, P

OBJECTIVE:To evaluate the cost-effectiveness of 3 therapeutic schemes in the treatment of Parkinson's disease (PD). METHODS:A total of 94 PD cases were randomly assigned into 3 groups:Group A (Benserazide tablets +carbidopa and Levodopa controlled release tablets),Group B (Benserazide tablets+Carbidopa and Levodopa controlled release tablets+Selegiline tablets) and Group C (Benserazide tablets+Carbidopa and Levodopa controlled release tablets+Entacapone tablets). After treatment for 8 weeks,the cost-effectiveness analysis were conducted for all the 3 groups. RESULTS:For Group A,B and C,the costs were 448.78,803.89,1 559.89 yuan,respectively; the total effective rates were 56.67%,83.33% and 85.71%,respectively; the cost-effectiveness ratios were 791.92,964.71,1 819.96,respectively. The incremental cost-effectiveness ratios of Group B and C were 1 332.00 and 3 826.14,respectively as against Group A. CONCLUSION:Group B is preferable for PD among the 3 groups.

Professor LI Guo-heng is one of famous TCM old doctors in our country.He is the main outstanding inheritor of Wei Shi Traumatology.He is skill in internal and external use of Chinese herb,manipulation and body guidance technique.He is good at treating injury congestion syndrome,Jin Chu Cao,Gu Cuo Feng with Wei Shi Traumatology.Combining differentiation syndrome with differentiation diseases,and using Chinese herb and manipulation,which has a good clinical efficacy.

BACKGROUND: The pathogenesis of alcoholic avascular necrosis remains unclear. OBJECTIVE: To introduce the physiological structure and pathologic changes induced by alcohol of the microenvironment of femoral head, and to review the research status of the influence of alcohol on the microenvironment of femoral head. METHODS: A computer-based online research of PubMed database for clinical and basic studyies concerning the effect alcohol on the microenvironment of femoral head published from 1990 to 2016. The pathological changes of alcoholic osteonecrosis of the femoral head were overviewed. RESULTS AND CONCLUSION: There are various theories about the pathogenesis of alcoholic osteonecrosis of thefemoral head, but the essence is the disturbance of blood circulation in femoral head, and long-term decrease in the nutrients and oxygen supplying of bone leading to bone degeneration and necrosis. Large-dose intake of alcohol will induce the imbalance of oxidation and anti-oxidation system, which dose harm to the microenvironment of femoral head. The change of oxygen supplying accelerates the necrosis of femoral head, the weakened differentiation of bone marrow mesenchymal stem cells into osteoblasts and the disturbance of bone resorption-formation imbalance finally result in the necrosis and collapse of femoral head. It is expected to provide a new therapeutic strategy for delaying or preventing the early femoral head necrosis by controlling the microenvironment of femoral head.

Objective To analyze the effect of cluster nutrition intervention and psychological intervention combined with compound Kushen injection on postoperative patients with esophageal cancer. Methods 80 patients with esophageal cancer who underwent postoperative radiotherapy and chemotherapy were divided into two groups. The control group was treated with chemotherapy alone. The observation group was treated with compound bitter ginseng injection and cluster nutrition intervention. Psychological intervention therapy. The total effective rate, the nutritional index before and after treatment, the SF-36 quality of life score and the complication rate were compared. Results The total effective rate and the post-treatment nutritional value of the observation group were higher than those of the control group. After treatment, the SF-36 scale was higher than the control group, the incidence of adverse reactions was lower than that of the control group(P<0.05). Conclusion The combination of intensive nutrition, psychological intervention and compound Sophora flavescens injection can improve the nutritional status, improve the curative effect, reduce the adverse reaction and improve the quality of life of patients with esophageal cancer after radiotherapy and chemotherapy.

Vitamin K deficiency is a common problem in neonates and infants,vitamin K deficiency bleeding can be life threatening.There is still a high incidence of vitamin K deficiency even if the prevention by retrospective analysis a large number of the global data.In recent years,with the increase of premature infants,incidence is higher than before,China is the same trend.There is no recognized prevention and treatment measures,and less related research data.Therefore,to carry out related investigation,to provide the basis for clinical prevention and treatment are an urgent task.