s:Primary chronic intestinal pseudo-obstruction (PCIPO)is a rare digestive syndrome characterized by derangement of gut propulsive motility which resembles mechanical obstruction, in the absence of any obstructive process. Treatment of intestinal pseudo-obstruction involves nutritional, pharmacological and surgical therapies, but it is often unsatisfactory and the long-term outcome is generally poor in the majority of cases. This article is aimed at reviewing the current knowledge on etiology, clinical features and management of patients affected by PCIPO.

One of the important missions of modern medical ethics is to strengthen the adjustment of medical ethics and advance the infiltration of medical ethics spirits to medical science to solve the basic ethical problems caused by ART.The adjustment of Medical ethics on ART are affected through ethical regulation,exampling, leading, educating etc.Medical Ethics Committee is an important form of realizing this kind of function,and it is also the evidence of the system of medical ethics. It has been an international practice to set up ethics committee in order to carry on ethics supervision for relevant medical course.The application and development in a healthy way of ART in our country is calling for the ethics committee of medical organizations to play effective role.

Objective To analyze the clinical application of misoprostol in the painless induced abortion analgesia.Methods 80 cases of painless induced abortion in pregnant women were selected as the subjects.They were randomly divided into two groups by the digital table method.The control group was not given drug before opera-tion,the observation group was given oral misoprostol before operation.The blood loss, operation time and adverse reaction rate of the two groups were observed and compared.Results In the control group,blood loss[(82.13 ± 8.76)mL],operation time[(15.64 ±4.43)min],and adverse reactions rate(30.00%) were higher than those in the observation group[(46.51 ±5.31)mL,(11.36 ±3.22)min,7.50%],the differences between the two groups were statistically significant(t=4.57,3.36,χ2 =6.65,all P<0.05).Conclusion Oral misoprostol before operation could reduce the amount of bleeding during operation,shorten the operation time.It was worth of popularizing.

Objective:To study the networks and ultrastructure of interstitial cells of Cajal(ICC) in rats' small intestine.Methods:Ten Sprague-Dawley rats were killed and fullthickness ileums of approximately 15 mm length were resected.Immunofluorescence which revealed ICC morphology and distribution in the gastrointestine was examined using a laser-scanning confocal microscope.Ultrastructures was evaluated by transmission electron microscopy.Results:There were 2 different subtypes of ICC in ileum which formed network and parallel distribution respectively.Ultrastructual analysis revealed no significant differences between the subtypes. Conclusion:The interstitial cells of Cajal have unique cell networks and ultrastructure character which were suitable with its functions.

Objective:To investigate whether the fish oil improves intestinal motility function during intra-abdominal sepsis and hypertension.Methods: 25 rats were divided into three groups.The rats were supplemented by gavage with: ①normal saline as control group(n=9);②fish oil(0.3%,n=8)and ③fish oil(0.6%,n=8)for 4 weeks before operation.The rats were killed on the 24th hour after operation.In vitro ileual smooth muscle contractions were recorded.Ileum sections were assessed pathologically.Immunopositivity of c-kit as markers of ICC-MY by confocal microscopy were evaluated.Results: In the bowel segment with NS,muscles showed a significant reduction in the frequency of contraction compared to that with FO.This change was associated with the changes of ICC-MY network.Conclusion:The intestinal motility may be protected by an enteral fish oil nutrition through attenuating injury of ICC-MY network.

Objective:To investigate whether an enteral fish oil immunonutrition during intra-abdominal sepsis and hypertension dose improve pulmonary function.Methods: We divided 25 rats into three groups.The rats were supplemented by gavage with:(Ⅰ)normal saline as control group(9);(Ⅱ)fish oil(0.3%,8) and(III)fish oil(0.6%,8).The cytokine levels were analyzed.The lungs were harvested,stained with hematoxylin-eosin,and analyzed. Results:Intra-abdominal sepsis and hypertension induced thickening of alveolar walls and inflammatory reaction.Fish oil decreased expression of pro-inflammatory cytokines(TNF-? and IL-1?),inhibitted infiltration of MPO positive cells,and protected pulmonary structure.Conclusion: The lung may be protected by an enteral fish oil nutrition through attenuating inflammatory reaction.

Objective To observe the clinical effect of psychological intervention combined with alendronate and low molecular heparin calcium on the treatment of senile osteoporotic fracture. Methods From February 2014 to March 2017, clinical data of 82 elderly patients with osteoporotic fracture in the first people's hospital in Jiande were retrospectively analyzed. All the patients were randomly divided into the control group and the experimental group with 41 cases in each group. The control group patients were given alendronate sodium and low molecular heparin calcium; At this basis, the experimental group were received psychological nursing intervention. The effect in the two groups was compared. Results After treatment, bone mineral density (BMD) index and pain scores in the two groups were significantly improved. BMD and pain scores in the experimental group were significantly better than those in the control group (P<0.05). The total effective rate was 95.12% (39/41) and the complication rate was 17.07% (7/41) in the experimental group, while in the control group were respectively 70.73% (29/41), 36.59% (15/41), the differences were statistically significant (P<0.05). Conclusion Psychological intervention combined with alendronate sodium and low molecular heparin on the treatment of senile osteoporotic fracture has significant effect, can effectively improve the clinical symptoms of patients, reduce the incidence of complications, with clinical application value.

ObjectivesTo explore the clinical significant for change o f serum enzyme with ACVD.MethodsThe serum enzyme of 150 cases wi th ACVD were investigated.ResultsThe serum enzyme of 150 cases with ACVD were significantly higher than that of the control group (P

Ischemic preconditioning in limb renders skeletal muscle itself or remote tissue or organ being able to resistant a subsequent more sustained ischemic insult.Its clinical application is very potent,which protects important organ such as heart,lung,brain,intestine,stomach,liver,et al.The mechanism refers to nervous or humoral factors,local or system factors,potassium channels,adenosine receptor,opioid receptor,mitochondrium.

Early study have been proved that Monoaminergic receptor are playing an important role in the progress of depression.At present,other receptors have been discovered which involved in the pathogenesis and treatment of depression.This paper is attempted to review the new progress of investigation into glutamate receptors,corticotropin-releasing factor receptors,neurokinin receptors and adrenocorticosteroid receptors related with depression mechanism respectively.