Objective:To design and implement equipment malfunctions online service system by using information technology, and to solve the defect of the traditional repair works, which makes traditional off-line repair service way transfer to online service mode, in order to improve the service quality of backup support.Methods: The actual situation of the hospital has been considered in this system. This system is developed by choosing ThinkPHP framework and jQuery technology, and it has set up four user management modes of administrator management, total audit management, department audit management, and common user management. Also the system has many functions: order with the repair personnel, the repair service, the repair progress review, and service statistics, etc.Results:This system effectively improves the work efficiency and management level, and it has a very good application prospect.Conclusion: Through the use of medical information system, the construction of hospital informatization will be promoted, and the clinical will also be better serviced.

Objective The purpose of the present study was to evaluate the effect of combined irbesartan and amiodarone to maintain sinus rhythm in patients with rheumatic heart disease after valve replacement. Methods One hundred and sixteen patients of rheumatic heart disease after valve replacement operation complicated with persistent atrial fibrillation were randomized to amiodarone monotherapy (n=55) or irbesartan plus amiodarone group(n=61). Electrical cardioversion was administered 2 weeks after of pharmaceutical treatment. Patients were followed up for 18 months. Left atrial diameter was measured at before and 6, 12, 18 months after treatment. Results After 12 months, the left atrial diameter in amiodarone monotherapy group was significantly greater than irbesartan plus amiodarone combined group (P

Objective:To explore the clinical presentations and symptom distribution in adults with attention-deficit/hyperactivity disorder(ADHD) among non-alcohol substance use disorder population,and to prove the effectiveness of adult ADHD diagnosis.Methods:Thirty adults with ADHD and thirty non-ADHD controls were selected from Beijing Compulsory Detoxification Center,matched with sex,age,and education.Data collection included the following:(1)Self-report measures of developmental history,employment history,social history and ADHD clinical symptoms.(2)Psychiatric interview using structured assessments included the Clinical Diagonsitic Interview Scale(CDIS)for Diagnostic and Statistical Manual of Mental Disorders(DSM-IV).(3)Evaluation for cognitive function with the Wechsler Adult Intelligence Scale-Revised Chinese(WAIS-RC).Results:(1)The clinical core symptoms(such as attention deficit,restlessness,and impulsive symptoms)among adulthood ADHD were similar to childhood ADHD except for some hyperactivity symptoms.(2)The symptoms of attention deficit,restlessness and impulsiveness were more frequently in both of adulthood and childhood ADHD than non-ADHD controls(P

The methylation of CpG island in promoter region of E-cad gene which usually leads to inactivation of E-cad gene is closely related to the occurrence, development, invasion, metastasis and prognosis of a variety of gastrointestinal cancer, such as esophageal carcinoma, gastric carcinoma, hepatocellular carcinoma,cholangiocellular carcinoma, carcinoma of gallbladder, pancreatic carcinoma and colorectal cancer. Further study would probably guide the early diagnosis, gene therapy, prophylaxis and predicting recurrence of tumor metastasis of gastrointestinal cancer.

Objective:To identify the expression of egfp-hri fusion on NIH3T3 cells which is carried by recombinant retrovirus. Methods:The egfp-hri fusion gene was integrated intoNIH3T3 cells by the infection of recombinant viral supernatant from the G418 resistent PA317 cells transfected stably with the plasmid of pLNCX-EGFP-C1-hri. The expression effect of egfp-hri fusion was visualized under the fluorescent microscope, while the expression levels of egfp-hri fusion protein by Western blot. Results:The observation from fluorescent microscope showed the green fluorescent was obviously observed in the cytoplasm , western-blotting showed the expression level of egfp-hri fusion gene increased by 83%and 81%, as compared with those uninfected cells and in the cells infected with empty vector, respectively. Conclusion:The infected NIH3T3 cells can express egfp-hri fusion protein successfully.

OBJECTIVE:To observe the efficacy of capecitabine combined with cisplatin in the treatment of advanced gastric cancer and its effect on invasion and metastasis of gastric cancer. METHODS:94 patients with advanced gastric cancer were ran-domly divided into control group(47 cases)and observation group(47 cases). Control group received 65-75 mg/m2 Docetaxel injec-tion,d1,continuous intravenous infusion of 2 h+15-20 mg/m2 Cisplatin for injection,d1-5,continuous intravenous infusion of 2 h in the dark. Observation group received 1 000 mg/m2 Capecitabine tablet,orally,twice a day+Cisplatin for injection(the same us-age and dosage with control group). 3-week was regarded as a treatment course,and it lasted 3 courses. Clinical efficacy,matrix metalloproteinase-2(MMP-2)and MMP-9 levels were observed,6 and 12 months survival rate and incidence of adverse reactions were followed-up. RESULTS:There was no significant difference in the total effective rate in 2 groups(P>0.05). Grade 1-2 liver dysfunction,thrombocytopenia,and the incidence of nausea and vomiting in observation group were significantly lower than con-trol group,6 and 12 months survival rates were significantly higher than control group,the differences were statistically significant (P<0.05). Before treatment,There was no significant difference in MMP-2 and MMP-9 levels in 2 groups(P>0.05). After treat-ment,MMP-2 and MMP-9 levels in 2 groups were significantly lower than before,and observation group was lower than control group,the differences were statistically significant(P<0.05). CONCLUSIONS:The efficacy of capecitabine combined with cispla-tin is similar to docetaxel combined with cisplatin in the treatment of advanced gastric cancer,but docetaxel combined with cisplat-in is superior in terms of reducing MMP-2 and MMP-9 and safety.

Heme oxygenase(HO) is a rate-limiting enzyme that catalyzes heme degradation.It catabolizes heme into 3 products: carbon monoxide(CO),free iron and bilirubin,which play an important role in keeping the steady state of the organism.In recent years,some studies show that the promotion of HO-1 expression can reduce ischemia-reperfusion injury of an organ transplant and regulate the transplantation immunological rejection.It has an important application prospect in liver transplantation.

Purpose:To evaluate the effect of preoperativ e chemotherapy or brachtherapy and radical hysterectomy on stage Ⅰb-Ⅱb locally advanced cervical cancer with high risk factors. Methods:preoperative chemotherapy or radiotherapy followed by r adical hysterectomy compared to radical hysterectomy alone in stage Ⅰb-Ⅱb cer vical cancer with higher risk factors(bulky,lower grade,small cell cancer or ade nocarcinoma). Results:①Pelvic lymphnode metastases rate was significantly decreased in the neoadjuvant chemotherapy arm compared with surgery alone(P 0.05). Conclusions:Preoperative chemotherapy followed by surgery is e ffective and superior to surgery alone in stage Ⅰb-Ⅱb cervical cancer with high risk factors.It might be able to reduce tumor volume and eliminate effectiv ely disease in lymphnodes and possibly micrometastases.It may be beneficial in improving quality of life of patients by decreasing the need for postoperative r adiotherapy. Response to chemotherapy may be a prognostic factor.Preoperative br achytherapy showed no significant advantage in eliminating lymphnodes matastases as compared to surgery alone.

0.05). IH scores of 15-PGDH in chorion of placenta and fetal membranes in PL were 1.5?0.6,2.3?0.8, respectively, in TL were 2.6?0.8,3.0?0.7, respectively, and in control group were 4.4?1.1, 4.1?1.2,respectively. IH scores in PL and TL were obviously lower than those in control group(P

For hundreds of years, scientists have been inspired by the regeneration phenomena in nature. Thanks to the development in the research tools for molecular biology, our understanding of the underlying molecular mechanisms involved in regeneration has been greatly deepened. Besides the increasing knowledge obtained from the studies on the molecular mechanisms of amphibian regeneration, accumulating evidence has proved that mammals may also have regenerative property, and the repair mechanisms should be conserved cross the species. Therefore, better clinical therapies are expected with the elucidation of regeneration mechanisms. Through introduction of the recent progress in amphibian appendage and mammalian regeneration, we expect the readers to have the fundamental understanding in this promising field.