1.Progress in clinicopathologic study on uterine smooth muscle tumor of uncertain malignant potential.
Chinese Journal of Pathology 2011;40(8):573-576
Cyclin-Dependent Kinase Inhibitor p16
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metabolism
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Female
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Genes, p16
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Genes, p53
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Humans
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Hysterectomy
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methods
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Ki-67 Antigen
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metabolism
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Leiomyoma
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genetics
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metabolism
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pathology
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surgery
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Leiomyosarcoma
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genetics
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metabolism
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pathology
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surgery
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Prognosis
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Smooth Muscle Tumor
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genetics
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metabolism
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pathology
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surgery
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Tumor Suppressor Protein p53
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metabolism
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Uterine Neoplasms
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genetics
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metabolism
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pathology
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surgery
2.Research progress on pharmacogenomics of antiretroviral drugs
Chinese Pharmacological Bulletin 2014;(7):889-892,893
AIDS has become a global disease,and a variety of drugs are used in the treatment of AIDS ,but the interindividual variabilities in efficacy and toxicity remain important limitations for the use of these drugs.Studies have shown genetic polymor-phism is the main reason for interindividual variabilities of drug reaction.In recent years,scholars focused on the pharmacog-enomics of anti-AIDS drugs and found that genetic polymor-phisms,in large part,determine the interindividual variabilities of the responese of these drugs.This paper reviews the research progress on pharmacogenomics of the four types of anti-AIDS drugs commonly used in China,including nucleoside reverse transcriptase inhibitors (NRTIs),non-nucleoside reverse tran-scriptase inhibitors (NNRTIs),protease inhibitors (PIs)and integrase inhibitors (raltegravir).
4.Biological characteristics of artificial bones
Bingnian CHENG ; Zhi LI ; Hongfang WANG ; Juan LI
Journal of Jilin University(Medicine Edition) 2006;0(04):-
Objective To synthesize a novel polymer POMs-CS/nano-HAP and study its biocompatibility and safety.Methods The biocompatibility was evaluated through the experiments including acute systemic toxicity test,pyrogen,intracutaneous test.Results The crystals of POMs-CS/nano-HAP were equal on sizes, which average diameter was 20 nm and length was 100 nm.By comparing,the polymer were better than those reported,which were closer to the natural bone.The material had no toxicity,no irritation to skin.(Conclusion The) POMs-CS/nano-HAP artificial bone possesses excellent biocompatibility.
5.Application of Tn5 Transposon Mutagenesis Technology in Molecular and Genetic Researches of Gram-negative Bacteria
Hong-Juan NIAN ; Li-Mei CHEN ; Kun-Zhi LI ;
China Biotechnology 2006;0(12):-
With development of wide-host-range vector systems,Tn5 transposon and its derivative vectors have been widely applied to genetic research of gram-negative bacteria.The applications of Tn5 transposon mutagenesis technology to genetic researches of bacteria were briefly discussed,including researches on biological control mechanisms of biocontrol bacteria,identification of bacterial essential genes,discovering virulence genes of bacterial pathogens,characterization of metabolism regulatory genes and genetic improvements of bacteria.
7.The most promising strategy targeted against cancer stem cells.
Zhi-xiong LIN ; Li-juan YANG ; Shi-ming ZHEN
Chinese Medical Journal 2011;124(24):4303-4303
8.Effect of Hedysarum Polybotys Saccharide on Insulin Resisance of Experimental NIDDM Rats
Zhi-Sheng JIN ; Juan-E LI ; Dong-Peng ZHANG ;
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(05):-
Objective To investigate the effect of Hedysarum Polybotys saccharide(HPS)on insulin resistance rats.Methods The model of type 2 diabetic-insulin resistance rat was successfully made by STZ and high caloric diet.Then the rats were intervene by Metformin(MT)and HPS.Results Compared with the model group,the level of blood glucose,INS and CP were lowered,ISI were improved and FFA were restrained by HPS.Conc(?)sion HPS can reduce the insulin resistance in multiple ways.
9.The Teaching Fashion of Microbiology in Occupation Technique College
Juan-Li WANG ; Yi-Qiang WANG ; Zhi-Mei WU ;
Microbiology 1992;0(02):-
In order to cultivate advanced person with ability,we should teach students some theoretics and more practical skill during microbiology teaching. after we using the measures “examining on theoretics and practical skill that must be mastering in the lesson”. Students had been more interested in microbiology,and advanced of knowledge. So “examining on theoretics and practical skill that must be mastering in the lesson” is better method in teaching of Microbiology in Occupation technique college.
10.Ecological Significance and Processes in Research of the Viable but Nonculturable State in Bacteria
Xiu-Juan WANG ; Lin ZHU ; Zhong-Zhi CHEN ; Yu LI ;
Microbiology 2008;0(12):-
The viable but noncuturable (VBNC) state is a survival strategy when bacteria are exposed to en- vironment stress. The VBNC state is part of the life cycle of non-differentiating bacteria, and it has a far-reaching impact on traditional bacteriology. Cells in the VBNC state fail to grow on the routine bacterio- logical media, here its significance in human health and environment science are detailed. Cells entering the VBNC state exhibit dwarfing and a number of metabolic changes in respiration rates and macromolecular synthesis. This paper summarized the variations in DNA and protein comparing to the culturable cells. We also discussed the ability of cells to resuscitate from the VBNC state and return to an actively metabolizing and culturable form. Some new methods for monitoring the VBNC state were listed. Finally the future was suggested.