Hyperhomocysteinemia is one of the independent risk factors of cerebrovascular diseases. Methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation often results in the increase of plasma homocysteine levels, but the relationship between the genetic polymorphism of MTHFR and cerebrovascular diseases is not significant.

Objective To observe the curative effects of the combined therapy of Folic acid,Vitamin(Vit) B6 and Vit B12 in youth stroke associated with hyperhomocysteinemia.Methods 150 youth stroke patients with hyperhomocysteinemia were randomly devided into low dose Folic acid,Vit B6 and Vit B12 treatment group(low dose group);high dose Folic acid,Vit B6 and Vit B12 treatment group(high dose group) and control group,50 cases in each group.Low dose group was taken by the treatments of Folic acid 2.5 mg/d,Vit B6 10 mg/d,Vit B12 0.5 mg/d;high dose group was taken by the treatments of Folic acid 5 mg/d,Vit B6 30 mg/d,Vit B12 1.5 mg/d;control group was not taken by the treatments of Folic acid,Vit B6 and Vit B12.The plasma homocysteine(Hcy)concentration was detected before and after treatment.The level of plasma Hcy 0.05).No obvious side effect was found in the three groups.Conclusions It is effective in the combined therapy of Folic acid,Vit B6 and Vit B12 in youth stroke associated with hyperhomocysteinemia.The effectiv rates are same by the low dose and high dose drug.The therapy is free from side effect.

Objective To investigate the effect of Xuesetong Dripping Pills combined with alprostadil intervention on serum brain natriuretic peptide in elderly patients with chronic congestive heart failure.Methods In 74 patients with chronic congestive heart failure, were randomly divided into observation group and control group, 37 cases in each group.Control group received conventional method.The observation group received Xuesetong Dripping Pills combined with alprostadil on the basis of conventional therapy.Compared the efficacy, the heart function level, walking test and level of serum brain natriuretic peptide between two groups after 15 days’ treatment.Results The total efficiency of observation group was 94.59%, which was higher than 75.68% in the control group, the difference was statistically significant(P<0.05).After treatment, the heart function level improvement in the observation group was better than the control group, the difference was statistically significant(P<0.05).After treatment, 6 min walking test in the observation group(316.4 ±20.7) m, was better than the control group(303.5 ±28.1) m, the difference was statistically significant(P<0.05).The level of serum brain natriuretic peptide in the observation group(608.9 ±158.1)ng/L, was lower than that of the control group(792.7 ±179.4) ng/L, the difference was statistically significant ( P <0.05 ) .Conclusion Xuesetong Dripping Pills combined with alprostadil has good curative effect in the treatment of chronic congestive heart failure,can relieve the abnormal increase of serum brain natriuretic peptide, improve blood circulation and heart function.

Objective To investigate the relationship of nitric oxide with nitric oxide synthase system in fetal rat kidney and the mechanism of renal injury after acute intrauterine ischemia(hypoxia)/reperfusion ischemia(hypoxia)/reperfusion. Methods Wistar rats of 21 gestational days were selected and divided into seven groups according to the different ischemia(hypoxia)/reperfusion time. The level of nitric oxide and the expression of nitric oxide synthase system were detected by biochemistry, immunohistochemistry and RT PCR. Results The NO level was decreased gradually with extension of ischemia, which was significantly different from sham group ( P

To summarize the experience about the preoperative and postoperative nursing of 11 cases with neurogenic bladder treated by sacral neuromodulation. The main nursing interventions of this procedure involved accurate recording of voiding diaries and postvoid residual, effective psychological nursing and health education of related disease information, standard videourodynamic examination. 11 patients acquired more or less benefit after the screening test and were discharged successfully, among them 2 cases had the permanent implantation of the stimulation device.

Adolescent ; Adult ; Female ; Humans ; Male ; Methanol ; poisoning ; Occupational Diseases ; chemically induced ; diagnosis ; therapy ; Poisoning ; diagnosis ; therapy

OBJECTIVE To analyze the incidence of the bifurcation of the facial nerve in mastoid segment and to give the anatomic information for mastoid surgery. METHODS From March 2005 to April 2006, there were 112 patients undergoing the decompress operations which the range included the mastoid segment. The bifurcation of the mastoid segment was recorded and compared with the preoperational High-resolution Computed tomography (HRCT) scans. RESULTS There were 5 cases with the nerve bifurcation. The incidence was 4.5 %. Four of those 5 cases were diagnosed preoperatively by HRCT scans (the accurate rate was 80 %). CONCLUSION Bifurcation of the mastoid segment was not rare. Otologic surgeon should pay attention to this anatomic variation to avoid injuring the branch of the facial nerve. HRCT scans were useful to find this abnormality.

Objective To analyze the skeletal structure features of temporomandibular joint (TMJ) by using cone beam computed tomography (CBCT) in patients with sleep bruxism. Methods CBCT scanning was performed in the intercuspal position in 30 patients with sleep bruxism (sleep bruxism group) and 30 health adults (normal group). The reconstruction of TMJ images were analysed by Invivo5 software. Measurements of horizontal section include antero-posterior diameter, medial-lateral diameter and axial angel. Measurements of sagittal section include acetabulum depth, aricular eminence inclination, anterior space, superior space and posterior space. Measurements of coronal section include force angle. Results There were no significant differences in both sides of TMJ between sleep bruxism group and normal group(P>0.05). Compared with control group, there were significant differences in antero-posterior diameter, medial-lateral diameter, acetabulum depth, anterior space and force angle in sleep bruxism group (P<0.05). There were decreased antero posterior diameter, me?dial-lateral diameter and increased acetabulum depth, anterior space and force angle in sleep bruxism group than those of control group. Conclusion The bilateral bone stuctures of TMJ are basically symmetry in patients with sleep bruxism. There is no significant change in condylar position in acetabulum , but there is a trend of absorbtion of anterior space and de?crease of condyle in patients with sleep bruxism.

ObjectiveThe investigate the action of self-care in geriatric type 2 diabetes patients.Methods96 geriatric type 2 patients were investigated through questionnaire. Results47 patients determined their blood sugar once or twice a week. 68 cases took medicine strictly.56 cases were good on alimentary control. 52 patients did exercise more than 1.5 h every day. The patients below 75 age old understood more about diabetes than that upward of 75.ConclusionTo improve the level of self-care on geriatric type 2 patients, the health care education must be done.

AIM:To study the effect of remifentanil on monophasic action potential and transmural dispersion of repolarization (TDR) in the 3-layer myocardium of isolated rabbit hearts .METHODS:Adult rabbits (n=18, 2.0 ~2.5 kg) were used to isolate the hearts for preparing Langendorff perfusion model .The hearts were randomly divided into 3 groups after perfusion with K-H solution for 15 min: the perfusion in control group ( C group ) continued for 60 min; the hearts in remifentanil group ( R group ) were perfused with 12 μg/L remifentanil K-H solution for 60 min; the hearts in remifentanil+aminophylline group ( RA group ) were given 60-min perfusion of 12 μg/L K-H remifentanil +30 mg/L aminophylline .The HR and 3 layers of myocardial monophasic action potential ( MAP) in the left ventricular anterior wall were recorded at time points after balanced infusion for 15 min ( T0 ) , and continued perfusion for 15 min ( T1 ) , 30 min ( T2 ) and 60 min ( T3 ) .The monophasic action potential duration of repolarization at 90%( MAPD90 ) and the transmural dispersion of repolarization (TDR) were calculated.The early afterdepolarization, delay afterdepolarization and arrhythmia were also observed.RESULTS:In R group, slower HR and prolonger MAPD90 and TDR at T1 ~T3 were observed as com-pared with those at T0(P<0.05).R group showed slower HR and longer MAPD 90 and TDR than C group and RA group (P<0.05).CONCLUSION:Remifentanil slows the HR, extends the MAPD90 and increases the TDR, thus being prone to induce reentry.Aminophylline makes HR faster and MAPD90 shorter, thereby reducing the TDR.