Objective To investigate the therapeutic effects of the losartan combined with atorvastatin on patients with diabetic nephropathy (DN).Methods 122 patients with DN were randomly divided into two groups,61 cases in the control group were received conventional therapy and added the losartan,61 cases in the observation group were treated by atorvastatin on the basis of the control group.The treatment time was 12weeks for each group.After 12 weeks,the systolic blood pressure (SBP),diastolic blood pressure (DBP),triglycerides (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C),fasting blood glucose (FBG),urinary albumin excretion rate (UAER),serum creatinine (Scr),and glycosylated hemoglobin (HbAIc) were measured.Results The total effective rate was 93.44％ in the observation group,and 75.41％ in the control group,with a statistically significant difference between two groups (x2 =7.54,P ＜ 0.01).After 12 weeks,the SBP and DBP were all changed more than before,DBP decreased more significantly (SBP:t =16.25,17.34,P ＜0.01 ;DBP:t =18.10,17.04,P ＜0.01); FBG,UAER,and HbAlc in the control group were significantly reduced (P ＜ 0.05) ; the TG,TC,LDL,-C HDL,-CFBG,UAER,Scr,and HbAlc of the observed group were significantly reduced more,too.TG,TC,UAER,and Scr of the observed group were significantly lower than the control group (P ＜ 0.05).Conclusions The losartan combined with atorvastatin that were used to treat patients with DN can reduce the urine albumin and protect the renal function.

The importance of designing experiments in the reform of experimental teaching was expounded.The achievements of reformation and exploration in the selection of experimental items,the improvement of teaching methods,the advancement of teachers' levels and the examination of students' grades in researching and designing experiments in pharmaceutical analysis were summarized comprehensively.

Objective To analyze the correlative factors of prognosis of neonatal stress-induced ulcer bleeding.Methods Fifty-four cases of NICU admitted stress-induced ulcer bleeding newborns were divided into mild group and severe group according to bleeding endurance,transfusion requirement,and clinical turnover.Compared with gender,gestational age,birth weight,and score for neonatal acute physiology(SNAP) Ⅱ and score for neonatal acute physiologyⅡ perinatal extension(SNAP-PE) Ⅱ of two groups.Results Based on the output of SPSS statistical package,the SNAP Ⅱand SNAP-PE Ⅱ had a significant deviation between two subgroups((?~2=)15.207,10.311 all P

Objective To explore the effect of employee assistance program on male nurses' professional values and professional identity.Methods Fifty male nurses participated in the program by group counseling and individual counseling.The professional values scale (NPVS-R) and the occupational identity scale were used to investigate the changes in their professional values and occupational identity before and after the intervention.Result After intervention,the occupational values and occupational identity of male nurses were significantly better than before intervention (P＜0.01).Conclusion The employee assistance program for male nurses can promote the formation of positive professional values and professional identity sense.

OBJECTIVE: To make a more scientific and transparent decision in new drug pricing and reimbursement. METHODS: A hierarchy structure model was established based on analytic hierarchy process with an imagined antidepressant drug as an example; the priority weights were calculated, and the multiple factors influencing pricing and reimbursement decision were evaluated synthetically to derive the synthetic evaluation results. RESULTS & CONCLUSIONS: The model can quantify part of the qualitative factors and provide reliable bases for drug pricing and reimbursement; although there are many factors and methodology issues need to be discussed when analytic hierarchy process is applied in reality, the method is realistic and feasible in drug pricing and reimbursement.

Objective:To investigate the demands for cardiac rehabilitation information in patients with coronary atherosclerotic heart disease (CHD) and influential factors.Methods:Information demands for cardiac rehabilitation in CHD patients were surveyed by questionnaire and the influential factors were analyzed by one-way ANOVA and multi-factor analysis of variance.Results:The score of demands for cardiac rehabilitation information in CHD patients was 3.86±0.53.Among them,the most urgent top 5 items were:drug knowledge,diagnosis and treatment,basic knowledge of the heart,emergency and safety and nutrition knowledge.The top 3-demand modes were:communication with medical workers,movies or videos to take home,and lectures.The score of demands for cardiac rehabilitation information was different in different age groups.The highest score was in the patients with age less than 60.There were different demands in different characteristic groups.Conclusion:The most urgent need and mode are drug knowledge and communication with medical workers,respectively.With the age increase,the demands for patients' cardiac rehabilitation information decrease.An individualized health education strategy should be developed according to the characteristics of CHD patients.

Objective To explore therapeutic efficacy of endoscopic biliary stent placement in the management of bile leakage following hepatobiliary surgery.Methods 11 cases of bile leakage following hepatobiliary surgery were reviewed retrospectively from January 2001 to December 2005.New clinical classifications of bile leakage were proposed: type I,leakage from cystic duct;type II,leakage from extrahepatic bile duct(diameter of leakage less than 1/3 diameter of biliary duct was type IIA;more than 1/3 was type IIB);type III,leakage from intrahepatic bile duct(leakage from intrahepatic bile duct cecum was type IIIA;leakage from intrahepatic bile duct under draining hepatic segments was type IIIB;above draining hepatic segments was type IIIC);type IV,leakage from Luschka duct.Results In 11 cases,there were 6 cases of type I,2 cases of type IIA,1 case of type IIIA,and 2 cases of type IIIB.4 cases were placed only stents,and Oddi sphincterotomy combined with stent placement were performed in 7 cases.Stents were taken out at 3 weeks(6 cases),1 month(2 cases),2 weeks(1 case),6 months(1 case) and 9 months(1 case) postoperatively.Abdominal pain was relieved in 11 cases after endoscopic treatment,with disappearance of biliary drainage from abdominal cavity and subsidence of jaundice.1 case was followed up for 6 months,and other 10 cases were followed up for 1-3 years,with no recurrence of abdominal pain,fever,jaundice and seroperitoneum,and hemobilirubin became normal.Conclusions Endoscopic biliary stent placement is one of effective therapeutic procedures in the management of most bile leakage following hepatobiliary surgery.New classification of bile leakage may be taken as a guide to select therapeutic procedures.

Objective:For the further studies on the physical foundation of medicinal effi cacy of decoction of Fructus Schisandrae,to study its constituents absorbed into blood of rats after oral administration.Methods:Serum pharmacochemistry of Chinese medicine was used,based on the established high performance liquid chromatography analytical method of plasma effective constituents,to identify the constituents originated from the preparation and their metabolites in the serum by comparing fi ngerprint in vitro with that in vivo.Results:Five constituents have been detected in the blood,they were compound 1,2,3,4,5.Conclusion:Compound ⅣandⅤexist originally in Fructus Schisandrae decoction(including schisandrin),compound 1,2and 3 might be the metabolites of original constituents.

Radiotherapy is the primary treatment for nasopharyngeal carcinoma, and the disease control rate and survival time are able to be greatly improved by enhancing the radiosensitivity. Via mechanisms such as binding to target genes mRNA 3'untranslated region (3'UTR), microRNA (miRNA) inhibits translation, which therefore regulates transcription of target genes and thus affect target protein expression. Recent research showed that miRNAs play significant roles in improvement of radiosensitivity in nasopharyngeal carcinoma. This article reviews mechanism of miRNA action to strengthen radiosensitivity of nasopharyngeal carcinoma and the future of clinical practice of miRNA in this disease.
3' Untranslated Regions ; Carcinoma ; Humans ; MicroRNAs ; pharmacology ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms ; drug therapy ; radiotherapy ; RNA, Messenger ; Radiation Tolerance ; Radiation-Sensitizing Agents

China ; Head and Neck Neoplasms ; surgery ; Humans ; Minimally Invasive Surgical Procedures