Acquired Hyperostosis Syndrome ; therapy ; Combined Modality Therapy ; Humans ; Integrative Medicine ; Male ; Middle Aged

Purpose:To study the secretion and gene expression of Angiogenesis factors in the patients with CML and study the effect of Angiogenesis in the occurrence and development of CML. Methods:Concentration of VEGF in peripheral blood was determined by using ELISA. Myeloid tissue was extracted from all CML cases and ITP patients to detect MVD by using CD34 labelling. At the same time the level of VEGF,b-FGF were detected by using RT-PCR in both peripheral blood and myeloid cells.Results:Our results showed that the concentration of VEGF was obviously higher in the peripheral blood of CML patients(177.53?153.45 pg/ml) than in those of control group(73.12?19.82 pg/ml). The gene expression of VEGF and b-FGF were both higher than those of control group. The difference has statistical significance(P

0.01). The new caries did not occur in the test group. DMF index was higher in the controls than that in the tested subjects(P

Objective: To establish a determination method of chrysophanol in Kuiyanqing Xiangkouye . Methods:HPLC with DiamondTM C18 column(4.6?200mm,5?m)was used . Methanol: 0.1 %phosphoric acid(85:15)was used as mobile phase . The flow rate was 1.0mL/min . The detection wavelength was at 254nm . Results:The linearity of chrysophanol was in the range of 0.06462～1.03392 ?g . The recovery was 97.67 %and RSD was 1.37 %. Conclusion:This method is convenient and with a good resolution and can be used for the quality control of Kuiyanqing Xiangkouye .

Objective To explore the validity of simulative employment training course on enhancing the core competitiveness of university students.Method We investigate the students with simulative employment trainin, graduates and recruiters through interview, symposium and questionnaire survey. Results The comprehensive quality and occupational capacity of students that completed simulative employment training had been improved. In the simulative employment training course,98%students thought their interview skills had been promoted, 90%recruiters were satisfied with the students,95%graduates who had worked consider that the simulative employment training were helpful. Conclusions Simulative employment training is effective for enhancing the core competitiveness of university students.

The premembrane and envelope proteins (prM-E),which contains the mainly protective antigen related with virulence and tropism,are the primary structural protein of flavivirus.However,prM-E in ZIKV is rarely understood.We have analyzed the structure and biological effects of prM-E in ZIKV by bionformatics methods.The prM-E proteins virus-like particles of dengue virus was introduced in the present.Then,the prM-E proteins virus like particles of ZIKV was prospected.

Objective To provide basic and scientific data for diagnosis of Kashin-Beck disease (KBD) and development of children in the endemic disease region of Xinghai, Qinghai Province. Method In March 2012, the radiographs of right hand of 278 children aged 7 - 12 in KBD areas from Xinghai County, Qinghai Province were taken by X-ray, and then these phalange bones were measured with electronic digital vernier caliper. All data were analyzed with SPSS 17.0. Results The length of middle and end phalanges offingers of the forefinger, middle phalanges offinger of the middle finger and middle phalanges offinger of the pinky of girls aged 8 [(15.76 ± 1.39), (10.86 ± 1.06), (18.69 ± 1.46) and (12.26 ± 1.51) mm] were higher than those of boys [(14.71 ± 0.96), (10.24 ± 0.87), (17.76 ± 0.99) and (11.27 ± 1.42) mm], and the differences were statistically significant (t = 3.058, 2.174, 2.603, 2.346, all P< 0.05). The length of end phalanges offinger of the forefinger and middle phalanges offinger of the ring finger of girls aged 11 [(12.37 ± 0.86), (19.71 ± 1.32) mm] were higher than those of boys [(11.56 ± 1.01), (18.67 ± 2.03) mm] with significant differences (t = 2.938, 2.070, all P< 0.05). There was no significant difference of length of phalange bones between boys and girls at other age groups (all P>0.05). 7 year old age group, the width of phalange bones(proximal thumb, middle phalanges offingers of the forefinger, proximal and end phalanges offinger of the middle finger, proximal phalanges offinger of ring finger and middle phalanges offinger of the pinky) of boys was significantly thicker than girls (t = 2.291, 3.151, 3.131, 2.814, 2.235, 2.129, all P < 0.05). The 8 year old age group, the width of proximal phalanges offinger of ring finger of boys was significantly thicker than girls (t = 2.952, P< 0.05); 10 year old age group, the width of proximal phalanges offinger of the middle finger, proximal and middle phalanges offinger of ring finger of boys was significantly thicker than girls (t = 2.114, 3.829. 2.234, all P< 0.05); 11 year old age group, the width of middle phalanges offinger of forefinger and ring finger of boys was significantly thicker than girls (t = 3.219, 2.094, all P< 0.05); 12 year old age group, the width of end phalanges offinger of thumb and forefinger, proximal and end phalanges offinger of the pinky of boys was significantly thicker than girls (t=2.181, 3.973, 3.128, 2.237, all P<0.05);the rest and comparison, no statistically significant difference (P>0.05). Conclusion The development of phalange bones of children aged 7 - 12 is in accordance with the specific changes of development at different stages.

OBJECTIVE:To provide reference for the realization of normalization and standardization of quality control and management of Pharmacy intravenous admixture service(PIVAS). METHODS:The management and effectiveness of PIVAS quali-ty control in our hospital were introduced from aspects of the establishment of internal quality control system,the key indicators and effects of quality control. RESULTS:According to checking items from aspects of examining once in a month,on prescription checking,preparation,infection control,equipments,drugs,consumable materials,sanitation;holding 1 monthly quality control reviews;and analyzing unqualified indexes and existing security risks,the quality control of PIVAS had achieved good results. The qualified percentage of quality control index was increased from 84%(Jan. 2016)to 90%(Jun. 2016),error rate in the same peri-od was decreased from 0.579‰ to 0.099‰. CONCLUSIONS:Developing quality control of the implementation of detailed quality control key indexes for the whole process of intravenous infusion in PIVAS can effectively regulate the position working process,re-duce preparation error and ensure the quality of infusion preparation.

In recent years, many modern spectral databases for complex materials ( such as soil, feed, forensic evidence materials, pharmaceuticals and oils) have been established based on molecular spectroscopy (UV, infrared, near infrared, Raman and fluorescence) both at home and abroad, which are playing more and more important roles in the agricultural and industrial production and science research. Spectral searching method is one of the key technologies to make full use of the molecular spectral database. This paper reviewed the progress in the basic and modified algorithm, strategy and application of molecular spectral searching methods, and put forward the scientific and technological problems that need attention and further research.

Objective To evaluate the feasibility and therapeutic effect of kyphoplasty in treating severe osteoporotic vertebral compressive fractures. Methods Thirty-five patients (48 vertebral bodies) with severe osteoporotic compressive fractures were included. There were 33 females and 2 males with the mean age of 74.2 years. The average compressive rate of the affected vertebral bodies was 77.0%. The thoracolumbar vertebrae were treated with kyphoplasties. Percutaneous puncture direction was adjusted according to compressive rate and shape of the vertebral bodies. The inflatable bone tamp was inserted into the fractured vertebral body. The balloon was inflated with low pressure and dilate-relieve-dilate method was applied. The balloon was deflated and withdrawn, leaving a cavity within the vertebral body, which then fulfilled with visualized bone cement. Preoperative and postoperative symptom level, complications and radiographic findings were recorded. Results All 35 patients tolerated procedure well. The mean heights of the anterior, mid and posterior vertebral body had improved from (0.8±0.1) cm, (0.8±0.2) cm, (2.1 ±0.8) cm preoperatively to (1.2±0.3) cm, (1.3±0.2) cm, (2.3±1.0) cm respectively after operation (P ＜0.05). There was significance difference between preoperative and postoperative heights of the anterior and mid vertebral body. The mean kyphosis was improved from 28.2°±5.2° before operation to 19.1°±4.9° after operation. Conclusion Kyphoplasty is feasible and effective for severe osteoporotic vertebral compressive fractures.