Environmental Exposure ; prevention & control ; Environmental Monitoring ; Humans ; Occupational Health Services ; organization & administration

Objective To investigate the effect of sodium arsenite combined with cigarette smoke solution on NF-?B in rat lymphocytes. Methods Rat lymphocytes were divided into 4 groups: the arsenite treatment group, the CSS treatment group, the arsenite and CSS treatment group, and the control group. Electrophoretic mobility shift assays was used to detect levels of NF-?B DNA binding. Western blot was used to detect protein expression of I?B?. Results Levels of NF-?B DNA binding in the CSS treatment group and the arsenite treatment group were significantly increased (P

Ginseng is a typical adaptogen which has resistance to various stresses. This effect is related to the hypothalamic-pituitary-adrenal (HPA) axis. As the main active ingredients, saponin has the similar structure to steroids. The regulation characteristics of ginseng saponin on the HPA axis are narrated from the aspects of total saponin and saponin monomers in this paper after the introduction of adaptation definition and HPA axis regulation mechanisms. Pharmacological effects of ginseng saponin and the regulation effect of HPA axis are summarized finally.
Adaptation, Physiological ; Adrenocorticotropic Hormone ; secretion ; Animals ; Corticosterone ; secretion ; Ginsenosides ; isolation & purification ; pharmacology ; Humans ; Hypothalamo-Hypophyseal System ; drug effects ; secretion ; Panax ; chemistry ; Pituitary-Adrenal System ; drug effects ; secretion

Objective To investigate the clinic effect of trans-artery intrahepatic transplantation of porcine islet in type 1 diabetic patients. Methods Four patients with type 1 diabetes were perfused newborn porcine islets through the hepatic artery.Fasting blood glucose(FBS), postprandial blood glucose (PBS), HBA1,dose of insulin and function of liver and kidney were measured before and after the transplantation.Results The levels of FBS,PBS and HBA1 were 7 4～13 5mmol/L,7 8～18 6mmol/L and 7 8～12 0mmol/L respectively before the transplantation. During one and half years after transplantation, the levels of FBS,PBS and HBA1 were 3 3～7 1mmol/L,6 0～8 8mmol/L and 6 4～7 6mmol/L respectively with notably reduced dosage of insulin(32～58%).The function of liver and kidney of the patients remained normal.Conclusions Trans-artery intrahepatic transplantation of porcine islet is effective and safe for type 1diabetic treatment.

Objective To explore surgical treatment through posterior approach to reduce the fracture and dislocation complicated with longitudinal ligaments and intervertebral disc rupture in the thoracic or lumbar spine. Methods Eighteen cases suffered from the fracture and dislocation complicated with longitudinal ligaments and intervertebral disc rupture in the thoracic or lumbar spine between January 2001 and May 2004, retrospectively were reviewed all the patients are male, aged from 19 to 58 years old (average 38 years). All the patients are paraplegia. The involved vertebrae are T11 to L 3. All the lateral X-ray films showed the fractured vertebra taking on wedged shape. The posterior vertebral body-height was decreased in six patients. The fractured vertebra lost its height by 1/4 to 3/4 of normal height. The upper vertebral dislocation extent was from 25% to 100%. Two cases complicated with lateral displacement. All the patients were operated on within posttraumatic 10 days. One of the two posterior surgical techniques was used for a given patient: 1) One technique is implantation of pedicle-screws in upper and lower vertebrae just adjacent to fractured vertebra. 2) Another technique is implantation of pedicle-screws both in fractured vertebra and its adjacent upper and lower vertebrae. Results All the patients were followed up 3 months to 3 years (average 18 months). 8 cases were treated with two-vertebrae 4 pedicle-screws implantation technique, the height of fractured vertebral body was not improved in 5 cases, partially improved in 3 cases. The dislocation of the upper vertebra adjacent to fractured vertebra was partially improved in 6 case, not changed in 1 case, got worse in 1 case. 10 cases were treated with three-vertebrae 6 pedicle-screws implantation technique, the height of fractured vertebral body was all improved by 80% to 100%. The dislocation of the upper vertebra was corrected completely in all the ten cases. Conclusion The procedure of three-vertebrae 6 pedicle-screws implantation is practical, effective and useful for treatment of the fracture and dislocation comlicated with longitudinal ligaments and intervertebral disc rupture in the thoracic or lumbar spine.

Objective To retrospectively analyze the correlation between uterine fibroid and ovarian blood supply, and to discuss the visualization of ovarian artery and uterine ovarian branch in uterine arterial embolization. Methods A total of 363 patients with clinically-confirmed uterine fibroid were enrolled in this study. Uterine arterial embolization was carried out in all patients. The visualization of ovarian artery and uterine ovarian branch during angiography was recorded. After the procedure the changes of uterine fibroid and ovarian functions were followed up. The results were statistically analyzed. Results The blood supply of uterine fibroid could be divided into three types: unilateral artery as the main source of blood supply (34.16%), bilateral balanced blood supply (43.80%) and unilateral uterine artery (22.04%). The visualization rate of uterine ovarian branch in bilateral balanced blood supply type was significantly higher than that of other two types (P<0.05). The visualization rate of ovarian artery at the side which was lack of blood vessels was higher than that at the opposite side (P< 0.05). Transient ovary functional impairment was observed in patients with visualization of uterine ovarian branch, which restored to normal in three months. No significant difference in the reduction of the tumor mass existed between each other among the different blood supply types. Conclusion The blood supply types of uterine fibroids have a parallel relationship with the ovarian blood supply from ovarian artery and/or uterine ovarian branch. Special attention should be paid to the uterine arterial embolization of the side that is lack of blood vessels, and it is needed to carefully observe the embolization extent, the flow velocity, etc. during the performance of embolization so as to avoid ovarian function impairment.

BACKGROUND:Spiral acetabular prosthesis has good stability during total hip arthroplasty.
OBJECTIVE:To observe the early therapeutic effect of Zweymüler spiral acetabular prosthesis in total hip arthroplasty for patients with developmental dysplasia of the hip.
METHODS:Totaly 38 patients (48 hips) with developmental dysplasia of the hip received total hip arthroplasty with Zweymüler spiral acetabular prosthesis from January 2011 to June 2013 were selected. The clinical effect was observed after the operation.
RESULTS AND CONCLUSION: A total of 38 patients were folowed up for 21-46 months (averagely 42.3 months). One case suffered from deep venous thrombosis. Harris scores and Charnely scores apparently increased after surgery compared with that before surgery. The mean length of the osteotomy was 2.42±0.48 cm, and the mean extended length of the affected limb was 4.58±1.15 cm. X-ray films showed that there was no disunion of the osteotomy, no subsidence and loosening of prosthesis. The position of the acetabulum was suitable. The healing time of bone graft was 3-11 months (averagely 5.3 months). The coverage of the acetabular component was 92.5%, with a good initial stability, and the excelent rate of the operation was 90%. The satisfaction rate of patients was 84%. These results indicate that the Zweymüler spiral acetabular prosthesis has the advantages of reasonable design, good initial stability, low loosening rate and high satisfaction degree. However, the number of cases of this study was relatively smal, the folow-up time was short, and only the short-term effect was evaluated. Thus, the midterm and long-term effects need to be observed by the folow-up evaluation.

Objective To explore the psychological behavior features between different sexual children with oppositional defiant disorder(ODD).Methods The subjects were sampled from grade 1 to 5 in a primary school in Ji-nan,Shandong Province.According to the diagnosed criteria,42 pupils were diagnosed ODD,which was the study group,and 556 pupils without ODD became the control group.The pupils and their families were investigated and as-sessed by using Achenbach Child Behavior Checklist (CBCL).Results According to CBCL,there was extremely sig-nificantly higher score of depression,obsessive -compulsive,hyperactive,aggressive,interpersonal behaviors in ODD boys [(5.00 ±3.73)scores,(4.88 ±3.65)scores,(5.21 ±3.49)scores,(1 0.1 0 ±6.85)scores,(2.88 ±1 .99) scores]than those in healthy control group [(1 .65 ±2.61 )scores,(1 .91 ±2.65)scores,(2.46 ±2.63)scores, (3.95 ±4.52)scores,(1 .34 ±1 .61 )scores](t =4.31 ,3.90,4.76,4.33,4.40;P =0.000,0.000,0.001 ,0.000, 0.000).There was significantly higher score of symptoms of somatization,indiscipline,schizoid -like behaviors in ODD boys with [(2.38 ±2.50)scores,(2.63 ±2.70)scores,(3.1 7 ±2.35)scores]than those in healthy control group [(0.85 ±1 .63)scores,(0.1 3 ±1 .76)scores,(1 .51 ±1 .72)scores](t =2.94,2.85,3.37;P =0.007,0.009, 0.002).There was extremely significantly higher score of depression,communication disorder behaviors in ODD girls [(5.44 ±4.1 2)scores,(3.1 1 ±2.93)scores]than those in healthy control group with [(2.50 ±3.34)scores, (1 .36 ±2.08)scores](t =3.57,3.38;P =0.000,0.001 ).A significantly higher score of hyperactive,aggression, cruelty behaviors in ODD girls [(4.67 ±4.41 )scores,(9.33 ±7.82)scores,(1 .1 7 ±1 .79)scores]than those in healthy control group [(1 .87 ±2.38)scores,(3.1 9 ±4.08)scores,(0.24 ±0.66)scores](t =2.67,3.30,2.1 8;P =0.01 6,0.004,0.043).Conclusions According to CBCL,there were more psychological behavior problems in ODD children than healthy children.A significantly higher difference was found in different gender.

Objective To explore the influencing factors of the pregnant women with preeclampsia in blood pressure,glucose and lipid metabolism to hypertension after delivery.Methods One hundred patients of preeclampsias in Obstetrics and Gynecology Department of Maternal and Child Care Sservice Centre of Weinan from April 2012 to May 2014 were selected as the observation group.One hundred maternal-health at the same period were selected as the control group.All observed objects were followed up from May 2014 to May 2015.The general situation,sugar metabolism,lipid metabolism were recorded when in group and folllowed up.The general situation,sugar metabolism,lipid metabolism in prenatal were contrasted in two groups of prenatal and postpartum.Influence factors for hypertension of preeclampsia in pregnant women after childbirth were analyzed.Results Family history of hypertension,history of long-term use of contraceptives,prenatal body mass index(BMI),postpartum BMI,systolic prenatal,antenatal diastolic in the observation group were higher than that in the control group.The differences were statistically significant (P＜ 0.05).The fasting glucose (FPG),fasting insulin antenatal,prenatal insulin resistance index,total cholesterol(TC),triglycerides (TG),low-density lipoprotein cholesterol (LDL-C) of prenatal and postpartum in the observation group were (4.51 ±0.48) mmol/L and (5.21±1.08) mmol/L,(10.11±3.88) mU/L and (9.68±4.97) mU/L,(1.64±0.65) and (2.34±1.48),(6.21±0.98) mmol/L and (5.14±0.51) mmol/L,(3.51±1.35) mmol/L and (1.41 ±0.79) mmol/L,(3.31±0.97) mmol/L and (2.69±0.56) mmol/L,higher than that in the control group ((4.12±0.51) mmol/L and (4.76±0.97) mmol/L,(8.19±2.99) mU/L and (7.25±3.96) mU/L,(1.47 ±0.42) and (1.79±0.79),(5.91± 1.01) mmol/L and (4.99±0.39) mmol/L,(2.96±0.87) mmol/L and (0.86±0.78) mmol/L,(3.01 ± 1.01) mmol/L and (2.46±0.47) mmol/L),the differences were statistically significant(t=5.238,3.690,2.069,2.005,3.225,2.015,2.917,3.600,3.089,2.200,4.661,2.961;P＜0.05).Prenatal and postpartum BMI (OR =1.356,95％ CI 1.012-2.102;OR =1.378,95％ CI 1.034-2.609),fasting blood glucose level of prenatal(OR=1.753,95％CI 2.307-59.257) and postnatal fasting insulin levels(OR =1.351,95％ CI 1.810-112.267),the difference of systolic pressure of prenatal and postnatal(OR=1.247,95％CI 1.208-108.323),the difference between prenatal and postnatal triglycerides (OR =1.119,95％ CI 4.540-77.559),the difference of insulin resistance index (OR =1.529,95％ CI 1.828-92.844) and the difference between high-density lipoprotein cholesterol hypertension (OR =2.547,95％CI 1.763-110.693) were the risk factors that can cause preeclampsia occurs hypertension after childbirth (P ＜0.05).Conclusion Preeclampsia with high blood pressure,abnormal glucose metabolism and lipid metabolism are the risk factors that can cause preeclampsia occurs hypertension after childbirth.

Objective To evaluate the clinical results of expansive cervical laminoplasty by anterior and posterior cervical decompression in the treatment of Cervical Spondylosis Myelopathy with developmental cervical stenosis.Methods Retrospective analyze 32 patients of cervical spondylosis myelopathy treated with expansive cervical laminoplasty by anterior and posterior cervical decompression from Mar 1995 to Aug 2000 years, there were 21 males and 11 females, developmental cervical stenosis (DCS) with cervical intervertebral disc protrusion in 25 cases, with the ossification of cervical posterior longitudinal ligament (OPLL) in 7 cases. Neural functionality (JOA Scoring System), cervical axial symptoms, and pre-and post-surgery dynamic cervical spine lateral x-ray films and cervical vertebra MRI were evaluated. Results 32 cases had been followed up for an average of 24.3 months, with an average age 58.9 years (range 38-72). The average rate of improvement of the third and sixth in month postoperative,the first and third postoperative year was 58.1%,65.9%,69.1% and 68.4% respectively;the excellent and good was 71.9%,81.3%,78.1%,77.3% respectivery. Cervical axial symptoms were reduced. Instability of the cervical spine were not found and decompression was confirmed on MRI. Conclusion Expansive cervical laminoplasty by anterior and posterior cervical decompression in the treatement of cervical spondylosis myelopathy with developmental cervical stenosis have good efficacy and it is a stable operative method.