Objective To investigate the feasibility and safety of laparoscopic myomectomy in patients with large uterine myoma and the tumor located at special sites. Methods A retrospective study of 142 patients underwent laparoscopic myomectomy was done.In the patients,all the myomas were ≥10 cm in diameter;located at the cervix,uterus posterior wall near to the isthmic uteri,or broad ligament.The procedure was completed according to the volume and location of the tumors.For large myomas,the muscle layer was resected to remove the tumor,after removing the major part of the lesion(cut into pieces before moving out),the rest small parts were cut completely.Ligation was used for large tumors with sufficient blood supply in the surface or subserous myomas.For the myomas located in the broad ligament,the ligament was opened to pull out the tumor,and then the tumor was cut into pieces and resected at the root. Results The procedure was completed by laparoscopy in all of the patients,except in one who received laparoscopy-assisted resection.The removed tumors weighed 44 to 1903 g.The operation time ranged from 30 to 175 minutes.Intraoperative blood loss was 10 to 800 ml.No serious complications occurred.Among the cases,follow-up was available in 68 patients for 2 years.During the period,ultrasonography showed recurrent myoma in 2 patients. Conclusions With the improvement of the skills of laparoscopic myomectomy,indications for the laparoscopic operation can be widened.