Objective To study the effect of treating fatty liever with Tiaozhisugan decoction combined with simvastatin. Methods A total of 60 cases with fatty liver were randomly recruited into a control group and a treatment group.The control group was treated with simvastatin, vitamin E, and pioglitazone, while the treatment group was additionally treated with Tiaozhisugan decoction on that basis. Results The total effective rate was 93.9% and 79.6% in the treatment group and the control group respectively, the difference showing statistical difference (χ2=2.586, P＜0.01 ) .Conclusion It was effective to treat fatty liver with Tiaozhisugan decoction combined with simvastatin.

Acupuncture Points ; Acupuncture Therapy ; instrumentation ; methods ; Child ; Child, Preschool ; Enuresis ; physiopathology ; therapy ; Female ; Humans ; Male ; Treatment Outcome

BACKGROUND:Studies have shown that emodin protects against intestinal ischemia-reperfusion injury by inhibiting the release of inflammatory factors. OBJECTIVE:To investigate the effect of emodin on renal ischemia/reperfusion injury after bone marrow mesenchymal stem cel transplantation. METHODS:Forty Sprague-Dawley rats were randomized into five groups (n=8 per group):sham group, model group (renal ischemia/reperfusion injury group), bone marrow mesenchymal stem cel group (cel transplantation group), low-dose emodin group, high-dose emodin group. Rats in the latter four groups were pretreated with or without different concentrations (30 and 60 mg/kg) of emodin for 7 days, and then were subjected to clamping bilateral renal pedicles for 45 minutes, fol owed by injection of 1 mL bone marrow mesenchymal stem cel suspension. Six hours after reperfusion, the pathological changes of renal tissues were examined by hematoxylin-eosin staining;the mRNA levels of tumor necrosis factorα, interleukin-6, interleukin-18, TLR2 and TLR4 detected by real-time fluorescence quantitative PCR;and the protein expression of COX-2, ICAM-1 and iNOS determined by western blot. RESULTS AND CONCLUSION:Compared with the sham group, rats in the model group showed obvious features of severe acute tubular damage and inflammatory cel infiltration. In the cel transplantation group, tubular epitheliael cel s were partial y lost with some inflammatory cel s infiltrated in the renal interstitium. In the emodin groups, the tubular lumen was practical y intact with little renal interstitial inflammatory cel s. Compared with the sham group, a significant increase in the mRNA levels of tumor necrosis factorα, interleukin-6, interleukin-18, TLR2 and TLR4 as wel as in the protein levels of COX-2, ICAM-1 and iNOS was found in the model group (both P<0.05). However, bone marrow mesenchymal stem cel transplantation attenuated this ischemia/reperfusion-induced increase in the expression of the above-mentioned factors (P<0.05). Furthermore, the effects of bone marrow mesenchymal stem cel transplantation were further augmented by pretreatment with emodin in a dose-dependent manner. These findings suggest that emodin can enhance the protective effects of bone marrow mesenchymal stem cel s on renal ischemia/reperfusion injury.

Objective To observe the clinical effects of treating chronic type B hepatitis with Gankang Granule combined with poly I-C and immune ribonucleic acid. Methods A total of 100 cases of chronic type B hepatitis were randomly recruited into a control group and a treatment group, 50 cases in each group. The control group was treated with poly I-C and immune ribonucleic acid, while the treatment group was treated with Gankang Granule on the basis of the control group. Results Symptoms in both groups were improved. 23 eases in the treatment group showed negative value of HBeAg,contrasting to 13 cases in the control group. 38 cases in the treatment group turned to be negative value of HBV- DNA, higher than the number of 23 cases in the control group. The treatment group demonstrated a significantly better therapeutic results than the control group (χ2 value was 6.267 and 6.345 respectively, both P＜0.05). Conclusion Gankang Granule combined with poly I-C and immune ribonucleic acid can obviously improve hepatic functions and symptoms of chronic type B hepatitis,shorten the course of disease, and increase the rate of negative value of HBeAg and HBV- DNA.

Adult ; Female ; Foreign Bodies ; surgery ; Humans ; Neck ; Oropharynx ; surgery

BACKGROUND: Hypoxia-inducible factor 1α may mediate mammalian cells to adapt hypoxia environment.OBJECTIVE: To observe high altitude hypoxia on the ultrastructure of the lung tissue of hypoxia-inducible factor 1α expression.METHODS: Sprague-Dawley rats underwent high altitude hypoxia intervention for 1, 2, 3 and 30 days. Control group was set. Four high altitude hypoxia groups consisted of Golmud, Qinghai at the altitude of 2 700 m from 5-m above sea level of Xi'an consuming 1 day, Tanggula region at 5 000 m above sea level consuming 2 days, and Tibet Nagqu at 4 500 m above sea level consuming 3 and 30 days, respectively.RESULTS AND CONCLUSION: Light and electron microscopy showed that acute high altitude hypoxia 2 day group presented apparent high altitude pulmonary edema, while the 30 day group of acute high altitude hypoxia of high altitude pulmonary edema was significantly reduced, but hypoxia-inducible factor 1α mRNA expression was significantly increased (P < 0.01). Results demonstrate that hypoxia-inducible factor 1α mRNA expression increase in lung tissues after hypoxic acclimatization can help ameliorate high altitude pulmonary edema.

The status and progression of therapy for recurrent nasopharyngeal carcinoma are expounded, including radio-therapy, surgery, chemotherapy and targeted therapy, etc. Radiotherapy is the most important mode that three-dimensional conformal radiation therapy and intensity modulation radiation therapy are strongly recommended in order to reduce the impairment of normal tissue. Surgical therapy is reasonable for the early stage patients who relapse less than a year from the initial treatment with surgical indication. Conventional radiotherapy with or without brachytherapy is recommended for those who relapse more than one year without surgical indication. Radiotherapy combining with chemotherapy, targeted therapy and sensitizer is proposed for the patients with local advanced stage by re-staging.

46 rabbits were divided into two groups. HRP was injected into one of the 7 segments of spinal cord (T_(11,12)、L_(1,2)、S(2～4)) unilaterally in 42 adult rabbits in the experimental group. HRP was also injected into the vein of the ear (2 cases) and cerebrospinal fluid (2 cases) as the control group. The hypothalamus were cut at 40 ?m. The sections were incubated with BDHC and OD by Mesulam's 8th and Edward's procedures. Labeled cell were found in the medial basal hypothalamus (MBH), ventromedial nucleus (VM), paraventricular nucleus (PV), dorsomedial nucleus (DM), posterior nucleus (PN), supraoptic nucleus (SN), lateral nucleus (LN), anterior nucleus (AN), perifornical nucleus and zona incerta in all cases. The PV was most heavily labeled. The LN, PN and DM were less so. Some labeled cells were found in the MBH, VM and AN. A few labeled cells were present in the SN. Labeled terminal and preterminal axons were found in the dorsolateral margin of the PV and in the LN、PN and MBH.Labeled terminals of the hypothalamus, which were discovered in this study, has not mentioned in the literature available to us. This study demonstrated reciprocal projection between the hypothalamus and the segments of the spinal cord innervating pelvic organs.

Three pentacyclic triterpenoids were isolated from the leaves of Cyclocarya paliarus Iljinsk. On the basis of chemical evidences and spectral data, they were identified as: 2?-hydroxyursolic acid (Ⅰ), 3-oxo-2?，23-dihydroxyolean-12-en-28-oic acid (Ⅱ)and arjunolic acid (Ⅲ). Ⅱis a new compound,named cyclocaric acid B. I and Ⅲ were obtained from this plant for the first time