The first-line chemotherapy with platinum-based regimens for 4 to 6 cycles is a standard care in advanced non-small cell lung cancer (NSCLC). However, for patients who got disease stabilization or maximal response after first line chemotherapy, how to choose safe and efficacy anticancer agents to extend first-line treatment and provide a better clinical benefit is deserving of more concerns currently. In this article,the clinical progress of the chemotherapy and molecular targeted agents as maintenance therapy for patients with advanced NSCLC is reviewed.

Atrioventricular septal defect (AVSD)is a frequently diagnosed congenital heart malformation affecting the atrioventricular valves and septa. Heart transcription factors play fundamental roles in atrioventricular valves development and atrioventricular septa formation. Now cardiac transcription factors ( GATA4, NKX2. 5,TBX5 ,ZIC3)have been identified to involve in the pathogenesis of AVSD in humans. Their abnormal expression or function change may cause atrioventricular valve and septa developmental anomalies. Here we review advances in the understanding of the relationship between these transcription factors and AVSD.

By analyzing the current situation of TCM science popularization, We found that internet is serving as the most influential and rapid developing media at present. Therefore, a through excavation and utilization of internet as a tool for TCM science popularization will not only expand TCM science popularization platform, enhance mass foundation, promote mass understanding and recognition of TCM, but also meet the need of TCM self-development.

OBJECTIVE:To study the protecting and therapeutic effect of compound Zigui capsule on climacteric syndrome and the mechanism of the action in rats,so that it may provide a theoretical basis for clinical treatment METHODS:The climacteric syndrome model was made by ovariectomy in rats and the effects of compound Zigui capsule on hemorheological parameters were observed RESULTS:Compound Zigui capsule could lower blood viscosity,plasma viscosity,blood reduced viscosity and red cell rigidity index It could also inhibit platelet adhesion CONCLUSION:Compound Zigui capsule has obvious preventive and therapeutic effects on rat's climacteric syndrome

Abscopal effect is for tumor therapy and control of tumor metastasis.it will produce consider-able eignifieance in clinical tumor therapy.The exactly mechanisms of this effect have not been recognized com-pletely so far,and researchers find this effect is associatod with immune system response,espeeiaHy the cell-me-diated immunity.The response of abscopal effect can activate antitumor immunologic response in vivo possibly through antigen releasing and presentation,activation of T cell and natural killer cell,the role of cytokine,in-flammatory reaction,apoptosis,and etc.

Objective:To compare the characteristics of allergic rhinitis animal models in two different animals(Guinea pigs and New Zealand rabbits) induced with various doses of toluene-2,4-Diisocyanate(TDI).Methods:Low dose and high dose of TDI olive oil solution was used as sensitizer to establish models of Guinea pigs and New Zealand rabbits.The typical symptoms and sings of Guinea pigs and New Zealand rabbits were respectively scored during modeling.After the last challenge,nasal mucosa of Guinea pigs and New Zealand rabbits were histopathologically examined and the level of histamine in nasal mucosa was measured by spectrofluorometer.The mortality rates and model success rates were record.Respiratory tracts of dead animals were dissected and histopathologically examined to find out the causes of their death.Results:Compared with control groups,all the Guinea pigs and New Zealand rabbits in model groups got typical symptoms and sings of allergic rhinitis.Histopathology examination of nasal mucosa showed eosinophile cells infiltrating obviously.The levels of histamine in nasal mucosa were highly increased(P

Objective To investigate the clinical efficiency and immune adjustment of oxymatrine capsule and acitretin in the treatment of psoriasis.Methods Eighty patients with psoriasis were randomly divided into treatment (T) and control (C) groups.The T group took orally oxymatrine one capsule (0.2g) three times a day and one acitretin (10 g) two times a day.The C group only took orally one acitretin (10 g) two times a day.The T and C groups were applied the same drug for external use.Moreover,another 40 normal volunteers were set as normal control group.The peripheral blood T cell subset CD3 +,CD4 +,CD8 +,CD4 +/CD8 + were detected in all the three groups (T,C,and normal) before and after treatment.Results The effective rate was 92.5％ in the T group,and 72.5％ in the C group with statistical significance (x2 =8.66,P ＜ 0.05).The symptom integral decline index of two groups before and after treatment has statistical significance (t =10.02,P ＜ 0.05).For the peripheral T cell subset CD3 +,CD4+,CD8 +,CD4 +/CD8 + in the T group,a significant difference was found between pretreatment and posttreatment [(57.13 ±8.14)％,(37.62 ±7.97)％,(33.01 ±2.97)％,(1.24 ±0.51)％ vs (60.09 ±11.53)％,(43.02±7.67)％,(25.63 ±4.24)％,(1.73 ±0.69)％,t =3.08 ～9.02,P ＜0.01].However,there was not any statistical significance between pretreatment and posttreatment in the C group (P ＞ 0.05).Conclusions The treatment of common psoriasis combined with oxymatrine capsule and acitretin had a good curative effect and it improved the imbalance of peripheral blood T cell subsets.

Objective To review and analyze the causes of infant malnutrition and its relation with the way of feed.Methods Infant malnutrition was analysed with the emphasis on pathogeny,the onset month of the birth, its complication and clinical reflection in 63 cases.Results Infant malnutrition occurred in the case with incorrect feeding way:feeding on low protein powdered milk or cereals untimely without considering the supplementary food. Malnutrition easily brought out other kinds of disease.Conclusion It is recommended that infants younger than 5 months should be fed on breast-milk.In case of no breast-milk or short,dairy products are introduced,especially in- fant formula,with adding supplementary food timely.If not so,infant malnutrition occurs.

Objective To simulate the blood flow features of the susceptible sites of atherosclerosis in vitro.The cell micro-patterning is to be obtained on the bottom of channel for the information about single cell or cell groups.Methods Poly-dimethylsiloxane(PDMS) flow channel and PDMS stamp were fabricated by soft lithography.Fibronectin pattern was formed on chamber bottom by micro-contact printing method and cells selectively attached on fibronectin pattern.Results The PDMS-patterned chamber that possessed favorable optical property and the PDMS stamps with different sizes were obtained.Cells attached on fibronectin pattern presented square array.Conclusion The fabricated methods are quick and simple.The chamber could be used for the advanced real-time investigation of cell mechanical behavior in vitro.