Objective To improve both the technique and the clinical application of CT-guided percutaneous aspiration biopsy for sacral lesions. Methods CT-guided percutaneous aspiration biopsy was performed in 21 patients with sacral lesions. By using Ackerman drilling needle, trigger type biopsy needle or Chiba needle, both bony and non-bony specimens were collected. Results The procedure was successfully done in all patients and the pathologic diagnosis was obtained in 95.2%. Failure occurred in one case as only necrotic tissue and blood clot were collected in biopsy. Conclusion As a simple, safe and reliable technique, CT-guided percutaneous aspiration biopsy is very helpful in making correct preoperative diagnosis, providing important preoperative reference for the surgeons.

The methylation of CpG island in promoter region of E-cad gene which usually leads to inactivation of E-cad gene is closely related to the occurrence, development, invasion, metastasis and prognosis of a variety of gastrointestinal cancer, such as esophageal carcinoma, gastric carcinoma, hepatocellular carcinoma,cholangiocellular carcinoma, carcinoma of gallbladder, pancreatic carcinoma and colorectal cancer. Further study would probably guide the early diagnosis, gene therapy, prophylaxis and predicting recurrence of tumor metastasis of gastrointestinal cancer.

Breast cancer is one of reproduction-endocrine related tumors, so the risk factors including environmental and genetic factors which can disrupt anabolism and function of estradiol may increase the risk of breast cancer. Persistent environmental endocrine disruptor chemical (EDCs) can disrupt anabolism and function of endogenous hormone and the degree of disruption may depend on genetic polymorphism. EDCs and metabolic enzyme genetic polymorphism were discussed in this paper. To study the risk factors of breast cancer, both of the environmental factors and the genetic factors should be included.

Objective To discuss the application of nursing care in CT-guided percutaneous biopsy of the pancreas.Methods The perioperative nursing measures were carried out in 21 patients receiving percutaneous biopsy of the pancreas under CT-guidance.Active,effective and comprehensive nursing procedures were adopted to closely cooperate with the whole process of percutaneous biopsy as far as possible.Results All the patients could actively cooperate with the physician during the whole process of percutaneous biopsy and the surgery was successfully completed in all patients.The technical success rate with only single puncture was 100%.No obvious complications occurred after the procedure.Conclusion In order to ensure that the patient will be able to cooperate with the CT-guided percutaneous biopsy of the pancreas,that the operation time can be shortened and that the postoperative complications can be avoided,perioperative nursing care is indispensable.

It is difficult to treat the internal carotid arterial (ICA) wall disease between C2 to C7 segment ( the definition of ICA by E. Bouthillier,1996) with present interventional radiological measurements , includling pseudoaneurysm, giant or wide neck aneurysm and complicated carotid cavernous fistula. Some literatures have reported a few cases treated with coronary covered stent (e.g. Jomed coronary stent, Symbiot coronary stent), with favorable results . However, these kinds of coronary covered stents are too rigid, with uneasinees to pass through in tortuous ICA, and often resulting in injury of vascular wall. The utility of covered stent in intracranial artery also caused controversies of exclusion of origins of arterial branches. We analyzed the functional anatomy of ICA and reviewed our experimental results and primarily clinical application on professional intracranial covered stent with special designed structure and delivery system for ICA, in order to explore the possibility of utility of covered stent in intracranial arteries.

Phenotypic conversion process of cells in blood vessels occurred after percutaneous transluminal angioplasty (PTA), which is similar to “recall” of angiogenesis. This article is an attempt in reviewing the major themes and more recent findings dealing with the phenotypic conversion and cellular source in three layers of arterial wall after PTA in the adult.

Objective To investigate effect of Splenic Aminopeptide Oral Lyophilized Powder on urinary retinol-binding protein and CRP in children of mycoplasma pneumonia infection with asthma .Methods 60 cases were randomly divided into 2 groups, 30 cases of control group were given conventional anti-inflammatory treatment, azithromycin.30 patients of Experimental group were treated with Spleen Aminopeptide Oral Lyophilized Powder treatment, two groups were treated for 7 days.30 cases of healthy children were selected, given no any treatment.After treatment, urinary retinol binding protein, blood urea nitrogen, creatinine, cough, wheezing symptom recovery, C-reactive protein, blood and other changes were compared between two groups.ResuIts Two groups of children with urinary retinol binding protein, urea nitrogen, creatinine levels were improved in different degrees, and in experimental group, urinary retinol binding protein, urea nitrogen and creatinine decreased significantly compared with control group (P<0.05).Two groups of children with asthma and wheeze improved in different degrees, and cough wheeze, cough and wheeze recovery time of experimental group had more improvement than those of control group ( P<0.05 ) .Two group of C reactive protein and white blood cell level both improved in different degrees, and the experimental group of C reactive protein and white blood cell levels were significantly lower than those of control group (P<0.05).ConcIusion Spleen Aminopeptide Oral Lyophilized Powder can significantly improve the infection status of children with mycoplasma pneumonia, and relieve cough and wheeze symptoms, lower urinary retinol binding protein and C reactive protein level, improve kidney function damage induced by hypoxia.

Objective To discuss the influence of nursing intervention on sleep quality and postoperative comfort of patients with percutaneous coronary intervention(PCI). Methods We divided 96 patients who were to receive PCI into the test group and control group with 48 patients in each group.The control group received routine nursing while the test group were given systemic nursing intervention based on routine nursing intervention.The sleep quality and incidence rate of complications were compared. Results The sleep quality in the test group was better than that of the control group (P ＜ 0.01 ).The ineidience of waist-back pain,dysuria,induced emiction,eatheter emietion,anaesthesia of lower limbs,fidget in the test group also decreased compared with the control group(P ＜ 0.05). Conclusions Systemic nursing intervention could improve the sleep quality and postoperative comfort for PCI patients

During radiotherapy, ionizing radiation can damage some structures of the heart, including pericardium, myocardium, cardiac valve, conducting system, and coronary artery. Radiation-induced cardiac injury can manifest as abnormalities in many aspects including myocardium enzymes, perfusion imaging, electrocardiogram, strain rate imaging.

AIM: The 6-minute walk test (6MWT) has been acknowledged as a simple and feasible study method of evaluating cardiorespiratory function, motor ability and quality of life in all testees. This study was designed to evaluate the value of 6MWT in patients with chronic obstructive pulmonary disease (COPD). METHODS: ①Fifty patients diagnosed with COPD were enrolled from Department of Respiratory Medicine in the Second Clinical Medical College of Jinan University from January 2001 to December 2006, including 34 males and 16 females, with a mean age of (70.1?8.9) years; and 62 patients with other diseases admitted in Department of Respiratory Medicine were taken as controls, including 30 males and 32 females, with a mean age of (66.5?10.1) years. Informed consents were obtained from all testees.②All patients were tested with 6MWT, lung function and MRC dyspnea scale, and the results were conducted for t test, ROC curve analysis, linear correlation analysis and multiple stepwise regression analysis. Pearson correlation coefficient was also calculated. RESULTS: All the testees were involved in the result analysis.①6MWT results: Compared with control group, the degression fraction of blood oxygen saturation was significantly higher and 6-minute walk distance was significantly shorter in the COPD patients (P