Mesenchymal stem cells (MSCs) have been found to home to tissues/organs with irflammation,the sites of growing tumors,as well as to participate in the formation of the tumor micro-environment,suggesting that MSCs play important roles in tumor growth and metastasis.To study the roles and mechanisms of MSCs in tumor growth and metastasis will provide new insights into tumorigenesis and tumor target therapy.

Parathyroid hormone-related protein (PTHrP) and its receptor type 1 (PTH1 R) are extensively expressed in the kidney,where they are able to modulate renal function.Animal and human studies have shown that PTHrP acts as an important mediator of diabetic renal cell hypertrophy by a meehanism which involves the modulation of cell cycle regulatory proteins and TGF-β1.Furthermore,angiotensin Ⅱ (Ang Ⅱ) appears to be responsible for PTHrP upregulation in these conditions.These findings provide novel insights into the well-known protective effects of Ang Ⅱ antagonists in renal diseases,paving the wav for new therapeutic approaches.

With the development of surgical techniques, the use of nipple-areola complex (NAC)-sparing mastectomy (NSM) has been increasing. Except for oncologic safety, the aesthetic outcome of surgery is greatly concerned by clinicians and patients. So far, there has been no consensus on the incision of NSM. This article reviewed the literature so as to provide some evidence for the selection of NSM incision.

Objective To explore the influence of blocking B7/CD28 co-stimulatory pathway by RNA interference on the rejection response in mice heterogeneous heart transplantation and its mecha- nism.Methods siRNA of which sequence specified to CD80 and CD86mRNA was synthesized in vitro respectively and transfected into donor derived myeloid dendritic cells (DCs).The expression levels of CD80 and CD86 mRNA and surface antigen CD80,CD86 were assayed by semi-quantitative reverse transcription polymerase chain reaction and flow cytometry before and after CD80siRNA and CD86siRNA transfection.Seven days prior to heterogeneous heart transplantation in mice,DCs modi- fied by siRNA were transfused into recipients intraveneously (DC interference group).At the same time,group of allograft transplantation,cyclosporine A (CsA)-treated (CsA injected subcutaneously postoperatively,5 mg.kg~(-1)?d~(-1)) group,group of isograft transplantation,and non-interference DC group (transfusion of non-interfered DCs pre-transplanting) were assigned.The graft survivals were individually recorded and the graft rejection grading was pathologically evaluated.Interleukin 2 (IL- 2),interferon?(IFN-?),and IL-10 mRNA expression levels in grafts tissue were determined.Results After siRNA transfected into DC,the expression levels of CD80 and CD86 mRNA were down- regulated significantly and the the antigen CD80~+ and CD86~+ reduced from 84%,67% to 35% and 30% respectively.As compared with groups of allograft and non-interference DC,survival of the grafts was significantly longer in DC interference group (P＜0.01),pathological grade of rejection significantly lower (P＜0.01),IL-2 and IFN-?mRNA expression levels lower,and IL-10 mRNA ex- pression levels higher in grafts tissue (P＜0.01).Conclusion Knocking down the molecule B7 expres- sion level in donor-derived myeloid DCs through RNAi,which could block B7/CD28 co-stimulatory pathway,could exhibit inhibitive effect on rejection response in mice heart transplantation.The mechanism might be due to induction of T lymphocyte anergy and Th cell differentiation deviating to T_H2.

Objective To summarize the nursing key points in nursing ovarian cancer patients with early postoperative inflammatory intestinal obstruction after non-surgical treatment value. Method The nursing data of 32 ovarian cancer patients with early postoperative inflammatory intestinal obstruction in our department in January 2010 to October 2016 were retrospectively analyzed. Results About 32 patients were treated with non-surgical treatment, cure time within 2~30d, averaged (7.80 ±5.98)d. No intestinal obstruction happened after resuming to normal exhaustion, defecation and dieting. Conclusion Such nursing measures as psychological nursing, gastrointestinal decompression nursing, nutrition support nursing and auxiliary therapy like promoting peristalsis recovery are key to the increase of cure rate of early postoperative inflammatory intestinal obstruction.

Activins ; administration & dosage ; pharmacology ; Animals ; Animals, Newborn ; Apoptosis ; drug effects ; Cerebral Cortex ; drug effects ; pathology ; ultrastructure ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Hippocampus ; pathology ; ultrastructure ; Hypoxia-Ischemia, Brain ; drug therapy ; pathology ; Injections, Intraperitoneal ; Male ; Microscopy, Electron ; Neuroprotective Agents ; administration & dosage ; pharmacology ; Rats ; Rats, Wistar ; Treatment Outcome

Objective To explore a new method in treating acute closed rupture of the Achilles tendon. Methods 22 cases of closed rupture of the Achilles tendon, which had been wounded within one week, were treated with short incision and tenocutaneous relaxing suture from 1994 to August 2001. Results The duration of follow up ranged from eight months to five years. According to Arner Lindholm criteria of therapeutic evaluation, excellent results were obtained in 19 (86.4% ), good in 3 (13.6% ), with the excellent and good rate being 100% . Conclusion Short incision and tenocutaneous relaxing suture is an effective treatment for acute closed rupture of the Achilles tendon because of its less suture tension and more blood supply protection. [

Intestinal tract is one of the target organ during surgical stress. When surgical stress becomes overwhelming , the integrity of intestinal mucosal barrier is destroyed. Microorganisms and toxin in the intestinal tract then enter blood circulation through the permeable intestinal mucosa, and trigger SIRS and MODS, This processes reversely aggravate intestinal mucosal necrosis and bacterial translocation, and lead to a vicious cycle. Radical total gastrectomy is a major surgical stress. After extensive abdominal surgery, cytokines and inflammatory mediators may cause intestinal mucosal edema, increased intestinal permeability, intestinal villus height reduced, shrinkage of mesenteric blood vessel, reduced blood flow, and intestinal barrier functional deterioration. Whereas ulinastatin can protect intestinal barrier function by reducing surgical stress,alleviating SIRS and improving immunity etc. This article reviewed the investigations of ulinastatin influencing the recovesy of intestinal barrier function after surgical stress.

Objective To assess the value and usage of real-time monitoring of the recurrent laryngeal nerve (RLN) during thyroid reoperation by RLN monitor. Methods One hundred and one patients were under general anesthesia and thyroidectomy. NIM-Response electromyographic (EMG) monitor system was used for assistant of dissection,exposure and protection of the RLN during the surgical procedures. Results There were 192 RLN were exposed during the surgeries in all 101 patients. The unilateral RLN injured in 10 patients was not specially explored the same side nerve. Among them 190 nerves were confirmed intact,the rest 2 nerves were resected because of tumor involving. Conclusion s NIM-Response electromyographic monitor system is sensitive and accurate for preserving the integrity of RLN during the thyroid reoperations. It is valuable for protecting RLN against iatrogenic injury. This system deserves general utilization for thyroid surgery,especially reoperation.

Objective To evaluate the usage situation and the trend of traditional Chinese medicine injection for activating blood circulation in our hospital. Methods The sales amount and drug use frequency (DDDs) and drug utilization index (DUI) of traditional Chinese medicine injection for activating blood circulation were sorted and analyzed in our hospital from the fourth quarter of 2011 to the third quarter of 2012. Results The total sales amount of traditional Chinese medicine injection for activating blood circulation gradually increased in our hospital during that time. The proportion of varieties with the ratio DUI sum/DDDs sort of closed to 1 (0.75≤order ratio≤1.25) in the three quarters of 2012 accounted for 53.33%, 53.33%, and 66.67%, respectively. This indicated that the usage of traditional Chinese medicine injection for activating blood circulation was more unreasonable, but tended to be reasonable. Conclusion The usage of traditional Chinese medicine injection for activating blood circulation was basically rational in our hospital, and efficacy of clinical pharmacist intervention was obvious. Effective and safe evaluation of traditional Chinese medicine injection can be further strengthened, in order to improve the efficacy and reduce the adverse reaction.