Signal transducer and activator of transcription 3(STAT3)is an important member of STATs family and is highly expressed in many kinds of cancer.It regulates the tumor growth by influencing the apoptosis of tumor cells and tumor angiogenesis and becomes a new target for tumor therapy.This article reviews the structure of STAT3,the stimulating factors of STAT3,the tumor growth regulating pathway of STAT3,and its potential as a target for tumor therapy.

目的观察中药熏蒸加电动牵引治疗腰椎间盘突出症的疗效。方法120例腰椎间盘突出症患者采取中药熏蒸加电动牵引。中药熏蒸每次30min,每日1次,10次为1个疗程。牵引每次30min,每日1次,10次为1个疗程。依据临床疾病诊断依据治愈好转标准评价疗效。结果 120例患者优84例(70%)、良21例(17.5%)、可12例(10%)、差3例(2.5%)。结论中药熏蒸加电动牵引是一种有效的治疗腰椎间盘突出症的方法。

This paper summarized the application of Female Sexual Function Index (FSFI), and introduced its scoring system.

Objective To investigate and compare the clinical value of the elastic grades score evaluation method and ultrasound elasticity imaging strain ratio method in identifying thyroid nodules.Methods A total of 120 cases confirmed by operation and pathology of the patients with thyroid nodules in our hospital were underwent ultrasound elasticity imaging detection,the thyroid nodules were identified with the elastic grades score evaluation method and ultrasound elasticity imaging strain ratio method respectively,and were compared with pathological results separately.Results The sensitivity,specificity and accuracy rate were 79.4％,81.3％,81％ with the elastic grades score evaluation method,the sensitivity,specificity and accuracy rate were 91.2％,90.3％,93.3％ with ultrasound elasticity imaging strain ratio method,of which was significantly higher with ultrasound elasticity imaging strain ratio method than with the elastic grades score evaluation methodby statistical analysis(x2 =28.170,P =0.000;x2 =34.219,P =0.000; x2 =17.928,P =0.000).Conclusion Ultrasound elastography strain ratio and rating score evaluation method can be used as an effective method in differentiating malignant from benign thyroid nodules,which can effectively improve the accuracy rate of the differential diagnosis of thyroid nodules and effectively remedy the diagnostic error band to cognitive differences with traditional ultrasound evaluation.The method of ultrasound elastography strain rate ratio was better with advantages of easy to operate,easy to learn and master,and easily accepted by patients,which is worthy of clinical application.

As the diagnosis and treatment levels increased, the cure rate and lifetime of the patients with breast cancer improved. In China,surgery and drug treatment received more attention, but the overall rehabilitation was ignored. This article summarized the status of breast cancer patients's rehabilitation in lymphoedema, upper limb dysfunction, psychological problem, sexual dysfunction, childbirth trouble,dystrophy, follow-up visit and family-society support, and so on.

Medical postgraduates are the future core force of clinical diagnosis and treatment,scientific research,education and sanitary administration.Therefore,to cultivate qualified professionals,the key of contemporary medical postgraduate education is to pay more attention to comprehensive quality training in order to make students adapt to the continuous development of society and medical model.The First Clinical College in Wuhan University has implemented the hospital administration internship in combination with social needs and explored the education model of contemporary medical students with comprehensive quality.

Adolescent ; Asthma ; blood ; drug therapy ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Interleukin-17 ; blood ; Male

Nuclear factor-E2 related factor 2 (Nrf2)can protect the normal cells from the damage of oxidants and electrophones,preventing tumorigenesis and metastasis.However,the abnormal activation of Nrf2 in tumor cells can lead to tumor development.Chemicals acting on Nrf2 pathway include activators and inhibi-tors,Nrf2 inhibitors can increase the chemosensitivity of the tumor,providing a new idea for the drug design of high-efficiency and low-toxicity.

Objective To understand the resistant characteristics of staphylococcusaureus and the relationship between eryth-romycin,clindamycin resistance phenotypes and its resistance mechanism.Methods 7 6 Saphylococcus aureus isolated from clinical specimens was identified and antimicrobial susceptibility tested by BD all-automatic microbiology analysis system.U-sing the D-test method to analyzed Erythromycin induced by clindamycin resistance.Genes (ermA,ermB,ermC and msrA) were detected by PCR methods.Results In 76 staphylococcus aureus straims gene ermA,ermB and ermC was found in 29 strains.The msrA gene was present in the 2 strains.The coincidence rate of ermA,ermB,ermC and msrA gene detection with erythromycin was 82.9%.The coincidence rate of ermA,ermB,ermC and msrA gene detection with chindamycin was 89.5%.Conclusion Clindamycin and erythromycin resistance of Staphylococcusaureus is related to the encoding of gene er-mA,ermB,ermC and msrA.

Objective To study the effects of ? carotene on rat liver fibrosis induced by carbon tetrachloride (CCl 4). Methods ① After being treated with CCl 4 for 3 weeks to induce the experimental rat liver fibrosis, rats were treated with ? carotene 250 000 U/kg body weight by oral feeding twice a week. The normal and the CCl 4 control group were also set. ② The liver pathological and ultrastructual change were studied. The content of rat liver hydrooxylproline, the expression of ? 2 (Ⅰ) collagen RNA and transforming growth facter ? 1 (TGF ? 1) were studied at the same time. Results In the treatment group, the liver fibrosis scores were fewer significantly than those in the CCl 4 group ( P