Signal transducer and activator of transcription 3(STAT3)is an important member of STATs family and is highly expressed in many kinds of cancer.It regulates the tumor growth by influencing the apoptosis of tumor cells and tumor angiogenesis and becomes a new target for tumor therapy.This article reviews the structure of STAT3,the stimulating factors of STAT3,the tumor growth regulating pathway of STAT3,and its potential as a target for tumor therapy.

目的观察中药熏蒸加电动牵引治疗腰椎间盘突出症的疗效。方法120例腰椎间盘突出症患者采取中药熏蒸加电动牵引。中药熏蒸每次30min,每日1次,10次为1个疗程。牵引每次30min,每日1次,10次为1个疗程。依据临床疾病诊断依据治愈好转标准评价疗效。结果 120例患者优84例(70%)、良21例(17.5%)、可12例(10%)、差3例(2.5%)。结论中药熏蒸加电动牵引是一种有效的治疗腰椎间盘突出症的方法。

This paper summarized the application of Female Sexual Function Index (FSFI), and introduced its scoring system.

Objective To investigate and compare the clinical value of the elastic grades score evaluation method and ultrasound elasticity imaging strain ratio method in identifying thyroid nodules.Methods A total of 120 cases confirmed by operation and pathology of the patients with thyroid nodules in our hospital were underwent ultrasound elasticity imaging detection,the thyroid nodules were identified with the elastic grades score evaluation method and ultrasound elasticity imaging strain ratio method respectively,and were compared with pathological results separately.Results The sensitivity,specificity and accuracy rate were 79.4％,81.3％,81％ with the elastic grades score evaluation method,the sensitivity,specificity and accuracy rate were 91.2％,90.3％,93.3％ with ultrasound elasticity imaging strain ratio method,of which was significantly higher with ultrasound elasticity imaging strain ratio method than with the elastic grades score evaluation methodby statistical analysis(x2 =28.170,P =0.000;x2 =34.219,P =0.000; x2 =17.928,P =0.000).Conclusion Ultrasound elastography strain ratio and rating score evaluation method can be used as an effective method in differentiating malignant from benign thyroid nodules,which can effectively improve the accuracy rate of the differential diagnosis of thyroid nodules and effectively remedy the diagnostic error band to cognitive differences with traditional ultrasound evaluation.The method of ultrasound elastography strain rate ratio was better with advantages of easy to operate,easy to learn and master,and easily accepted by patients,which is worthy of clinical application.

As the diagnosis and treatment levels increased, the cure rate and lifetime of the patients with breast cancer improved. In China,surgery and drug treatment received more attention, but the overall rehabilitation was ignored. This article summarized the status of breast cancer patients's rehabilitation in lymphoedema, upper limb dysfunction, psychological problem, sexual dysfunction, childbirth trouble,dystrophy, follow-up visit and family-society support, and so on.

Medical postgraduates are the future core force of clinical diagnosis and treatment,scientific research,education and sanitary administration.Therefore,to cultivate qualified professionals,the key of contemporary medical postgraduate education is to pay more attention to comprehensive quality training in order to make students adapt to the continuous development of society and medical model.The First Clinical College in Wuhan University has implemented the hospital administration internship in combination with social needs and explored the education model of contemporary medical students with comprehensive quality.

Adolescent ; Asthma ; blood ; drug therapy ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Interleukin-17 ; blood ; Male

Objective To compare the therapeutic effect of topical application of tea polyphenol versus pimecrolimus versus tacrolimus for monobenzone-induced vitiligo-like depigmentation in mice.Methods Twentyfive 3-week-old female C57BL/6 mice were randomly and equally divided into 5 groups:negative control group,model group,tea polyphenol group,pimecrolimus group,tacrolimus group.Monobenzone 45％ cream was applied to the back of mice in all the five groups except the negative control group once daily for 40 consecutive days to establish a model of vitiligo-like depigmentation.During the induction of depigmentation,the tea polyphenol group,pimecrolimus group and tacrolimus group were topically treated with tea polyphenol,pimecrolimus and tacrolimus respectively,and the model group remaining untreated.The depigmentation of hairs and skin was observed by naked eyes on a daily basis.Tissue specimens were obtained for histological examination from depigmented skin at nonapplication sites in mice after the end of the experiment.Hematoxylin-eosin staining was conducted to analyze lymphocytic infiltration,reflectance confocal microscopy to observe melanin and melanocytes in skin,and immunofluorescence assay to detect CD8+ T cell infiltration.Results Depigmentation occurred in both application sites and non-application sites of mice in the model group.Compared with the model group,the tacrolimus,pimecrolimus and tea polyphenol groups showed delayed depigmentation,reduced degree and area index of depigmentation,and attenuated lymphocytic infiltration and CD8 + T cell infiltration in depigmented maculae at application sites.In addition,the therapeutic effect of tacrolimus was stronger than that of pimecrolimus and tea polyphenol.Conclusion Tea polyphenol,pimecrolimus and tacrolimus are all effective for the treatment of vitiligolike depigmentation in mice.

Objective To construct an recombinant adenovirus vector of vascular endothelial growth factor small interfering RNA(Ad5-VEGFsi) and to observe its inhibitory effect on the cell proliferation of human leukemia K562 cells. Methods The specific human VEGF siRNA was subcloned into the shuttle plasmid pSES-HUS and then cotransfected with plasmid pAdeasy-1 to produce pAd5-VEGFsi by homologous recombination. The identified recombinant plasmid pAd5-VEGFsi was packaged and amplified in 293 cells. At 72 h after the transfection of Ad5-VEGFsi into K562 cells, VEGF mRNA expression and the protein level of VEGF in the cell culture supernatant were determined by RT-PCR and ELISA, respectively. Cell proliferation was measured by MTT assay and cell apoptosis by flow cytometry. Results The recombinant adenovirus Ad5-VEGFsi was successfully constructed. Ad5-VEGFsi with the titer of 4.6?1011 pfu/ml was harvested by CsCl gradient purification. Compared with those in the control, EGF mRNA in cells decreased by 66.55% (P

In order to study the values of MR/CT to the diagnosis, differential diagnosis, treatment and prognosis of systemic lupus erythematosis with neuropsyehiatric disorders (SLE-NP), MR/CT image changes of 22 examinations of skull/spinal cord in 16 patients with SLE-NP were analyzed. The results showed that the images of 18 examinations were abnormal (81.8%), including ischaemia/infarct (9 times), haemorrhage (3 times), focal demyelination (3 times), and cerebral atropy (6 times). The areas involved including basal ganglia (10 times), anterior horn of lateral ventricle (5 times), pons (1 time), and spinal cord (2 times). MR/CT is sensitive for the examination of lesions of SLE-NP, and the total positive rate is as high as 81.8%. Its high resolution rate can display the nature and areas of the lesions, which may provide valuable reference for the early diagnosis, differential diagnosis, treatment, evaluation of therapeutic efficacy and prognosis of SLE-NP.