Strontium-89(89Sr)therapy has been recognized as an effective method for treating bone metastases. It functions as a calcium analog that binds with collagen matrix produced by the MC3T3-E1 cells during collagen mineralization. 89Sr emits pure β rays which palliate bone pains and reduce the number of new metastasis sites. Response to 89Sr is affected by factors such as the location, size and histological type of lung cancer, the type of metastasis and the duration of treatment, and can be predicted by relief of bone pain, elimination of metastasis, CD4 +/CD8 +, ALP, and others. 89Sr therapy is safe and effective. Repeat administration or combined used with other treatments can improve the therapeutic effect of 89Sr.

Objective To explore the clinical features,treatment methods and effects of late-stage burned complicated with stress ulcer.Methods The clinical data of 206 burned patients were retrospectively analyzed,and the clinical features,treatment methods and effects of burned patients complicated with stress ulcer were analyzed.Results In 206 patients,there were 42 late-stage burned patients complicated with stress ulcer(20.4％),of which 34 cases were cured(81.0％),8 cases died(19.0％) (3 cases died of stress ulcer bleeding,5 cases died of stress ulcer bleeding complications).Conclusion The probability of late-stage burned complicated with stress ulcer is high and dangerous.For the patients with late-stage burned patients complicated with stress ulcer,early enteral nutrition,gastric mucosal protection,wound sepsis to prevent wound infection,the treatment measures should be effectively put into practice,which will be good for making patients stable,and then the patients can be cured.

Objective :To establish a simple, reproducible brain edema model induced by endotoxin in infant rats and explore the role of intracellular free calcium and calmodulin (CaM). in the development of brain edema. Methods: A total of 45 infant rats were divided randomly into endotoxin treated( n = 36) and control( n = 9) group. The animals were intraperitoneally injected with 10mg/kg of endotoxin or saline respectively. The brain tissue intracelluar free [Ca2 + ] as well as the expression of CaM was detected by fluorescence and protein hybridizaton methods respectively. The tissue water content,Evans Blue content and pathology under electronic microscope were also observed. Results:Brain water and EB content were remarkably increased in endotoxin treated animals compared with those in the control, in which the intracellular free [Ca2+ ] was also significantly increased and the expression of CaM up - regulated. Electron microscopic studies revealed that the blood - brain barrier(BBB)was disrupted with neuronal degeneration,neurogliocyte swelling and necrosis. Conculsion :These results suggest that LPS increases the intracellular free [Ca2+ ] ,and activates the CaM - dependent function via Ca2+ /CaM pathway,which might relate to the increased BBB permeability and brain edema formation.

OBJECTIVE To study the influence of enzyme detergent for improving the quality during the cleaning of medical instruments.METHODS The 360 pieces of contaminated instruments for manually cleaning were divided into two groups with 180 pieces each, one group as test one immersed in Lionser enzyme solution 5 minutes at 1∶200 and another one as control immersed in non-enzymatic detergent 30 minutes at 1∶200.Eventually flush all instruments using free water.RESULTS Significant difference(P

ObjectiveTo observe the effect of Sanfeng Rougan Tang on the type of Ganyang Shangkang essential hypertension.Methods42 essential hypertension patients in type of Ganyang Shangkang Zhen were treated with Sanfeng Rougan Tang. The anti-hypertension medicine remained if the patient had taken. The blood pressure and symptoms of the patients was recorded before and a month after treatment.ResultsAfter treatment, the blood pressure and clinical symptoms of the patients had been significantly improved. The ratio of the blood pressure control was 95.2%, and of the primary symptoms control was 94.4%.ConclusionSanfeng Rougan Tang is effective on the type of Ganyang Shangkang essential hypertension.

ObjectiveTo investigate the effect of psychological intervention on quality of life (QOL) of patients with mammary carcinoma.Methods64 patients with mammary carcinoma were divided into intervention group (n=36) and control group (n=28), and psychological status and QOL of patients of two groups were analyzed after treatment.ResultsThe psychological status and QOL of intervention group was better than that of control group (P<0.05～0.001).ConclusionThe psychological intervention in full stage being in hospital can improve QOL of patients with mammary carcinoma, and it is clinically significant to improve cure rate and survival rate of patients.

Objective To compare the clinical effects of low-temperature plasma ablation combined with adenoidectomy and decolle-ment in the treatment for patients with sleep apnea syndrome.Methods Totally 68 patients with sleep apnea syndrome who underwent elec-tive surgical treatment in our hospital from June 2013 to February 2015 were selected as the study objects.According to the order of treat-ment,the patients were randomly divided into the control group and the observation group,with 34 cases in each group.The control group were treated by routine decollement.The observation group were treated by low-temperature plasma ablation combined with adenoidectomy.After operation,the 2 groups were followed up for 6 months.The improvement effects of different operative methods in clinical symptoms and prog-nosis of patients with sleep apnea syndrome were compared.Results The total effective rate in the observation group (97.06%)was higher than that in the control group (82.35%),and the difference was statistically significant (P <0.05).The postoperative VAS pain grading of the observation group was relatively lower.The normal proportion (50.00%) was significantly higher than that in the control group (11.76%).Patients with moderate and severe pain in the control group accounted for 44.12% and 14.71% respectively,which were signif-icantly higher than those in the observation group(P <0.05).The incidence of postoperative bleeding in the observation group(2.94%)was significantly lower than that in the control group while the incidence of fever was higher than that in the control group (P <0.05).After oper-ation and at the end of the follow-up,OSA-18 score of the observation group decreased significantly and were (46.66 ±7.87)and (33.47 ± 10.59)respectively.The decreased range was greater than those in the control group (P <0.05).Conclusion To adopt low-temperature plasma radiofrequency ablation combined with adenoidectomy in the treatment of patients with sleep apnea syndrome can improve the surgical treatment effect,reduce postoperative pain,reduce the incidence of postoperative bleeding,optimize patients’quality of life and improve the prognosis.

Objective To evaluate the effects of inhaled nitric oxide (iNO) therapy combined with conventional ventilation in the infants with persistent pulmonary hypertension of the newborn (PPHN).Methods NO inspiration was added for 22 infants with PPI-IN ventilated with FiO2≥0. 9,PIP≥30 cm H2O,PEEP≥3 cm H2O,RR≥50 bpm for 4～6 hours,with SpO2 still < 90% and PaO2 <55 mm Hg. The iNO concentration started at (10～20)×10-6 for 20 infants,and (20～40)×10-6 for 2 infants. The iNO would be stopped when the concentration reached 40×10 -6 without any sign of improvement. The SpO2 ,blood gas analyses,blood pressure, heart rate and NO: concentration were moraitored during therapy and the resulting data compared to readings before administration of int. Results Clinical situation were significantly improved in 20 (91%) of the infants with SpO2 gradually going up after 10 minutes of int. Before iNO,mean Fit2 was 0. 9±0. 1 ,SpO2 was(76. 3±13.3)% ,and Pat2 was (46. 4±10. 1 ) man Hg. From 1 to 6 hours after iNO,SpO2 increased to(95. 1±3.8)% ,Pat2 increased to(92. 8±24.7) mm Hg,FiO2 decreased to 0.6 s0. 1.The differences were significant (P < 0. 01 ). Eighteen of 22 (82%) infants surviving. Conclusion iNO is effective in alleviating PPHN in infants. There are no remarkable side effects. It is more beneficial to start the iNO concentration at (10～20)×10-6 while some infants may need NO concentration at up to (20～40)×10-6.

Objective To explore the curative effects,prognostic factors,and adverse reactions of different treatment modalities of chemotherapy in patients with non-small cell lung cancer (NSCLC).Methods151 NSCLC patients were randomly assigned into 3 groups to undergo concurrent chemoradiotherapy ( n = 43 ) ,sequential chemo-radiotherapy ( n = 49 ) ,or pure chemotherapy (n = 59).The clinical data were analyzed.ResultsThe short-term effective rates of the concurrent and sequential chemo-radiotherapy groups were 81.4% and 73.5% respectively with no significantly difference between them,but both significantly higher than that of the pure chemotherapy group ( 39.0% ,both P ＜ 0.05 ).The mortality of the concurrent cherno-radiation group was 53.5% ,significantly lower than those of the sequential chemo-radiotherapy and pure chemotherapy groups (67.3% and 67.8% respectively,both P ＜0.05).The median survival time of the concurrent chemo-radiotherapy group was 26 months,significantly longer than those of the sequential chemo-radiotherapy and pure chemotherapy groups ( 12 and 11 months respectively,both P ＜ 0.05).The l-year survival rates of the 3 groups were 80.2% ,47.1%,and 45.6%.The 2-year survival rates were 58.2% ,38.5% ,and 24.4% ,and the 3-year survival rates were 32.7% ,27.5% ,and 0,respectively.The white blood cell decrease rates of the grades Ⅲ～Ⅳ of the concurrent chemo-radiotherapy group were significantly higher than those of the other 2 groups (both P ＜0.05 ).There were no significant differences in the rates of radiation esophagitis and radiation pneumonitis between the concurrent and sequential chemo-radiotherapy groups.Age,performance status score,clinical staging,and treatment modality were the 4 influencing factors in the prognosis of NSCLC ( all P ＜ 0.05 ).Conclusion Relatively safe with tolerable adverse reactions,concurrent chemo-radiotherapy is superior to sequential chemo-radiotherapy,particularly to pure chemotherapy,in increase of median survival time and survival rate in treatment of NSCLC.Age,PS,clinical staging and therapy method are independent indicators influencing the prognosis.

Objective To study the effect and the possible mechanism of delavirdine on muhidrng resist-ance-aasociated protein 2(MRAP2)-mediated multidrug resistance in LLC/cMOAT cells. Methods MTT assay was used to determine the effects of delavirdine on proliferation of LLC/CMV and LLC/cMOAT cells. The inhibitory effects of vincristine (VCR),cisplatin (DDP),adriamycin (ADM) and etoposide (VP-16) used alone or in combi-nation with delavirdine on the proliferation of LLC/CMV and LLC/cMOAT cells were evaluated by MTT assay. The cell cycle distribution, the apoptosis rate of the cells treated with different concentration of delavirdine and the intra-cellular concentration of ADM were determined by flow cytometry (FCM). Results Delavirdine at the concentration of 4 μmol/L and below showed no significant cytotoxicity to LLC/CMV and LLC/cMOAT cells. The resistance of LLC/cMOAT cells to VCB, VP-16, ADM and DDP were 9.58,1.11,2.98 and 3.96 folds of that of LLC/CMV cells. When 2 μmol/L delavirdine was added, the resistance was 5.21 and 2.55 folds respectively;when 4 μmol/L dela-virdine was edded,the resistance was 7.56 and 3.03 ,while 2,4 μmol/L delavirdine made no significant changes to the chemosensitivity of LLC/CMV cells to VCR and DDP(P>0.05). Cellular cycle analysis demonstrated that 0,6, 12,24 hours after co-cultured with delavirdine the amount of cells at G1 phase increased from(38.92±0.15)% to (56.87±2.23)%,(65.36±2.76)% and (74.77±5.06)%. The cell apoptosis rate increased from 1.77% to 17.45% and 28.52% when treated with delavirdine at 2,4 μmol/L and VCR for 24 h. When treated with 2,4 μmol/L delavirdine, ADM accumulation in LLC/cMOAT cells was enhanced significantly(P<0.05). Conclusion DLV can partially reverse the multidrng resistance of LLC/cMOAT cells, and the reverse effect correlates to the concentration. The possible mechanism may involve the growth arrest at G1, increasing of intracellular drug concen-tration and promoting apoptosis.