Magnetic resonance imaging (MRI),a commonly used imaging technique,has been extensively investigated in lung cancer diagnosis and staging.Many studies have demonstrated that MRI can be used for the differential diagnosis of benign and malignant pulmonary nodules and for the screening of lung cancer; it also has important value in TNM staging of non-small cell lung cancer (NSCLC),with equivalent sensitivity and specificity to 18F-fluorodeoxyglucose (18F-FDG) PET-CT,which suggests that MRI can be used as an alternative imaging modality in noninvasive diagnosis and staging of NSCLC.

Objective:To evaluate the etiology,elinic characteristics,diagnosis and treatments of spontaneous perforation of the bile duct in children. Methods:The clinical data of eight children with spontaneous perforation of the bile duct between 1998 -2006 were analyzed retrospectively. Results:5 of 8 cases were diagnosed bile duct perforativn before operation,all the patients recovered favorably after T-tube and pelvic drainage. 3 children complicated with choledochal cyst were cured afterⅡstage radical operation. Conclusions:the etiology of spontaneous perforation of the bile duct in children is unclear, panereaticobiliary confluence malfunction (PBCM) maybe the main reason. Peritoneocentesis is very important to the diagnosis, which is difficult in child preoperatively. The effective surgical treatments are T-tube and pelvic drainage. The children complicated with PBCM needⅡstage radical operation,and long term follow up are necessary for the children present with spontaneous perforation of the bile duct without PBCM.

Objective:To investigate the effect of ultrasound on the ultrastructure and expression of P-gp of Neuroblastoma cell in order to discuss the mechanisms of ultrasound affecting the chemotherapeutic sensitivity of SK-N-SH cell. Methods:The SK-N-SH cells were divided into the experimental group and the control group. In the experimental group,the cell suspensions were exposed to ultrasound irradiation. In the control group,the cell suspensions were exposed to sham irradiation . The changes of ultrastructure of tumor cells were observed by scanning electron microscope and the expression of P-gp in two groups were detected. Results:(1) In the pictures took by scanning electron microscope,we found that: the configuration of tumor cell changed and there were some holes of different diameters on the cell membrane and the numbers of microvillus reduced or disappeared after ultrasound irradiation.(2) The result of immunocytochemisty showed the expression rate of P-gp in SK-N-SH cells in the control group was 56.23%?9.86% vs 34.86%?6.19% in the experimental group (P

Objective To summarize the perioperative nursing experience in nursing children with formaral angulation deformity treated with sreminobicular crib external fixator. Method The clinical data of 15 children with formaral angulation deformity treated with sreminobicular crib external fixator were reviewed. Results All 15 children got recovered, with the femora extended by 4~9 cm. After operation, all of them were affected by knee flexion dysfunction and foot drop to varied extents, which were improved satisfactorily after systematic training. Conclusions The systematic and progressive training can prevent knee flexion dysfunction and foot drop. Careful observation and effective nursing play an important role in the treatment of formaral angulation deformity.

Meckel′s diverticulum is the most common congenital anomaly of the gastrointestinal tract. Most ca-ses are asymptomatic,while it can be symptomatic when complications happened,its complications often expressed as hematochezia,abdominal pain,vomit,fever,and so on. When signs or symptoms arise from a Meckel′s diverticulum, morbidity and mortality will increase. So make a definite diagnosis of the diverticulum play an important role in the treatment of Meckel′s diverticulum. In this essay,now illustrate the meaning of imaging examination about the diagnosis of Meckel′s diverticulum,wish to make a diagnosis as soon as possible.

Objective To study the ultrasonic characteristics of fetal cutaneous hemangioma and the association with perinatal outcomes.Methods Five fetuses with cutaneous hemangioma were detected by gray-scale and color Doppler ultrasound,compared with the result of pathology and hematology examinations after birth.Results Of the 5 cases diagnosed by ultrasound,3 had arteriovenous fistulas.In these 3 cases two fetuses developed high-output cardiac failure,and one developed cardiac insufficiency and thrombocytopenia.Finally one fetus was induced,one fetus died in the uterus and one neonate survived.The other two fetuses who had small tumors diagnosed by ultrasound did not develop any perinatal complications, and the neonates had favourable prognosis.Conclusions Massive hemangiomas are frequently associated with life-threatening complications such as high-output heart failure,thrombocytopenia and disseminated intravascular coagulopathy(Kasabach-Merritt syndrome).

Objectiv To explore the effects of chromium (Ⅵ) on the levels of malondialdehyde (MDA), the final product of lipid peroxidation in peripheral blood of mice and the micronucleus rate of polychromatic erythrocytes (PCE) in peripheral blood. Method 60 Kunming mice were divided randomly into 6 groups averagely. 4 groups were selected as exposure groups which were exposed to 10.27, 13.83, 20.74, 41.48 mg/kg calcium chromate by oral perfusion, one time per day, for 6 days. The negative and positive control group was exposed to distilled water and cyclophos phamide (40 mg/kg) respectively. After exposure, the levels of MDA and micronucleus rates of PCE were determined. Results Significant increases of the levels of MDA and the micronucleus rates of PCE in peripheral blood of mice were observed, which were associated with the increases of the exposure doses of chromium (Ⅵ). Significant positive correlation was observed between the micronucleus rates of PCEs (x) and MDA(nmol/ml) levels (y) in peripheral blood (y=3.705+930x,r=0.958, P

Objective To investigate the effects of Gynostemma Pentaphyllum on serum markers of liver fibrosis in cholesterol-induced non-alcoholic fatty liver disease (NAFLD) in rabbits. Methods Forty adult male white rabbits were randomly divided into a normal control group, a model group, a treatment group and a simvastatin group, with 10 rabbits in each group. NAFLD was induced with a high-cholesterol diet. After modeling, the rabbits in the treatment group were intragastrically administrated with Gynostemma Pentaphyllum 5 mg/(kg?d), the simvastatin group with simvastatin 5 mg/(kg?d), and the model and normal control groups with the equal volume of distilled water for 9 weeks. The serum levels of total cholesterol (TC) and triglyceride (TG), the serum inflammatory maker C-reactive protein (CRP), the serum markers of liver fibrosis such as hyaluronic acid and laminin (LN), and the TG level in the liver tissue were detected. Results Compared with the normal control group, the serum levels of TC (60.50 ± 9.77 mg/L vs.1.30 ± 0.44 mg/L), TG (1.72 ± 0.61 mmol/L vs. 0.85 ± 0.39 mmol/L), CRP (256.79 ± 30.78 mg/L vs. 8.71 ± 1.41 mg/L), HA (798.8 ± 69.4 ng/ml vs. 121.2 ± 6.8 ng/ml),LN (964.8 ± 62.8 ng/ml vs. 142.4 ± 12.2 ng/ml) in the model group were increased significantly (all P<0.01). Compared with the model group, the serum levels of TC (36.44 ± 6.57 mmol/L vs. 60.50 ± 9.77 mmol/L), TG (1.31 ± 0.39 mmol/L vs. 1.72 ± 0.61 mmol/L), CRP (68.77 ± 10.78 mg/L vs. 256.79 ± 30.78 mg/L), HA (420.8 ± 60.2 ng/ml vs. 798.8 ± 69.4 ng/ml), LN (449.8 ± 56.6 ng/ml vs. 964.8 ± 62.8 ng/ml) and the TG level in the liver tissue (0.52 ± 0.10 mmol/L vs. 0.77 ± 0.08 mmol/L) in the treatment group were decreased significantly (all P<0.01). The TG level in the liver tissue in the treatment group was significantly lower than that in the simvastatin group (0.52 ± 0.10 mmol/L vs. 0.59 ± 0.09 mmol/L;P<0.05). There were no significant difference in the serum levels of TC, TG,CRP,HA and LN between the treatment group and the simvastatin group (all P>0.05). Conclusions Gynostemma Pentaphyllum may regulate lipid metabolism, alleviate inflammation, and decrease serum markers of liver fibrosis, and might protect against liver fibrosis in rabbits with NAFLD.

By means of a planimeter and skulls adjusted in the eye-ear plane, measurements of areas of the foramen ovale, spinosum, lacerum, jugulae and orifice of the canalis caroticus on both sides of the external surface of the skull base have been taken on 100 adult skulls collected in Chengdu. The symmetry of these areas has been studied. The main results of the study are given below: 1. In 4% of the whole series, the area of the foramen ovale is approximately equal on the two sides and the difference in area between the two sides is less than 1%. In 44%, the right side is larger, and in 52%, the left is larger. 2. In 5% of the whole series, the area of the foramen spinosum is approximately equal on the two sides. In 42%, the right side is larger, and in 53%, the left is larger. 3. In 4% of the whole series, the area of the foramen lacerum is approximately equal on the two sides. In 46%, the right side is larger, and in 50%, the left is larger. 4. In 3% of the whole series, the area of the foramen jugulae is approximately equal on the two sides. In 76%, the right side is larger, and in 21%, the left is larger. 5. In 3% of the whole series, the area of the anterior part of the foramen jugulae is approximately equal on the two sides. In 50%, the right side is larger, and in 47%, the left is larger. 6. In 17% of the whole series, the area of the intermediate part of the foramen jugulae is approximately equal on the two sides. In 37%, the right side is larger, and in 46%, the left is larger. 7. In 2% of the whole series, the area of the posterior part of the foramen jugulae is approximately equal on the two sides. In 79%, the right side is larger, and in 19%, the left is larger. 8. In 5% of the whole series, the area of the orifice of the canalis caroticus is approximately equal on the two sides. In 58%, the right side is larger, and in 37%, the left is larger. Moreover, a quantitative analysis of the bilateral areas has been carried out. The foramen area is highly positive in correlation With the product of its length and width. Therefore, the regression formulas of the areas are as follows: The foramen ovale-right, ■=1.5129+0.6699x (r=0.9417); left, ■=0.3695+0.6876x(r=0.8949). The foramen spinosum-right, ■=0.7827+0.6089x (r=0.8755); left, ■=0.3499+0.6695x (r=0.9207). The foramen lacerum-right, ■=9.4190+0.4480x (r=0.9147); left, ■=13.5198+0.4082x (r=0.8493). The foramen jugulaeright, ■=18.3913+0.5092x (r=0.8843); left,■=11.3561+0.5744x (r=0.9193). The anterior part of the foramen jugulae-right, Y=3.3141+0.4858x (r=0.8330); left, ■=3.2294+0.4854x (r=0.8452) The intermediate part of the foramen jugulae-right, ■=2.5434+0.4311x (r=0.7942); left, Y=1.7547+0.5227x (r=0.8366). The posterior part of the foramen jugulae-right,■=1.3470+0.6311x (r=0.8273); left, ■=0.9110+0.6586x (r=0.9480). The orifice of the canalis caroticus-right, ■=1.0986+0.6794x (r=0.9128); left, ■=1.5038+0.6590x (r=0.9219). (x is the product of the length and width of its foramen).

The morphological characteristies and distribution of the choline acetyltransferase (ChAT)-like immunoreactive neuronal elements in the sacral and coccygeal spinal cord of the cat were studied by avidin-biotin combined immunohistochemical technique. The results were as follows:1. The ChAT-positive neuronsIn the ventral horn, ChAT-positive motoneurons were located in the motor columns. These neurons can be divided into three types: the large multipolar neurons, the medium-sized multipolar neurons and the small motoneurons. The color of anti-ChAT reaction product in the large and medium-sized motoneurons varied from light to moderate brown, but the small motoneurons were heavily stained.In the intermediate zone, three groups of ChAT-positive parasympathetic preganglionic neurons were observed in 3 areas: the intermediolateral nucleus (IL) in the lateral part of lamina Ⅶ, the intermediomedial nucleus (IM) dorsal-lateral to the central canal, the intercalated nucleus (IC) looated between IL and IM. The somata of these neurons were round, oval, and fusiform in shape. In the lamina Ⅶ, there were some prominent ChAT medium-sized multipolar neurons named partition cells, scattered among the extended fibers of the parasympathetic preganglionic cells. In the vicinity of the central canal could be observed small CHATpositive cells.In the ventral part of the dorsal commissural nucleus region, a number of ChAT-positive cells were present. They were round, oval and fusiform in shape and small in size (averaging 11.91?m?17.38?m). Occasionally, they were observed in the dorsal part.In addition, some of the ChAT-positive neurons were scattered in laminae Ⅲ-Ⅴ.2. The ChAT-positive fibers and terminals.The ChAT-positive punctate structures were observed throughout the sacral and coccygeal spinal cord resembling terminal branch and terminals. The density of the distribution of the punctate structures was arranged, from high to low, in the following order: the ventral horn, intermediate zone, central gray matter and dorsal commissural nucleus region, and the dorsal horn. In the dorsal horn, many of these punctate structures Were concentrated in two laminae, the major one being lamina Ⅲ and a minor one lamina Ⅰ. But in lamina Ⅱ, they were rare. In the ventral horn such punctate structures were often closely contacted with large and medium-sized ChAT-positive motoneuronal somata and dendrites. Some axonal terminal branch with varicosities closely surrounded a somata and bases of dendrites, and formed contacts with the same somata and its dendrites. In the intermediate zone, there were many transverse fibers associated among the parasympathetic preganglionic nuclei.